Hi-Risk/Recurrent/Advanced PCa Video Chat, June 19, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics
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WEBINAR next week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at https://tinyurl.com/ancanparpwebinar
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Editor’s Pick: Hot flashes flare up! (rd)
Topics Discussed
Switching to darolutamide; is ARV7 still relevant?; cabazitaxel (Jevtana) vs docetaxel (Taxotere); mega fatigue may warrant a drug holiday; starting Pluvicto on top of chemo; Ambrx ARX517 trial; troublesome hot flashes are a flashpoint; picking the right GU med onc; starting immunotherapy while tapering on steroids; pectin supplements
Chat Log
Len Sierra sent · 5:28 PM Darolutamide inhibited the transcriptional activity of AR mutants identified in the plasma of CRPC patients progressing on traditional therapies. In particular, darolutamide significantly inhibited the transcriptional activity of the F877L, H875Y/T878A, F877L/T878A, and the previously unreported T878G AR mutants, that transform enzalutamide into a partial agonist.
John A sent · 5:33 PM Liu et al. Selective degradation of AR-V7 to overcome castration resistance of prostate cancer. Cell Death Dis. 2021
AnCan – rick sent · 5:38 PM Oliver Sartor now at Mayo
AnCan – rick sent · 5:49 PM Depo-Provera
George Southiere sent · 5:56 PM ACTH(adrenocorticotrphic) stimulation test = patient given ACTH and adrenal gland function is assessed- usually done by Endocrinologist
John A sent · 5:57 PM thanks
George Pat Martin sent · 6:00 PM I’m worn out. Gonna log off . be back next week
AnCan – rick sent · 6:04 PM Venlafaxine
Len Sierra sent · 6:05 PM https://embrlabs.com/products/embr-wave-2
AnCan – rick sent · 6:07 PM Embr watch.. d/c
Ancan50 sent · 6:07 PM Depo provera
George Southiere sent · 6:08 PM Gabapentin has helped me due to my severe neuropathy and has helped the hot flashes for me
sent · 6:09 PM I take 600mg gabapentin 3 times a day now. It never helped with my hot flashes.
Len Sierra sent · 6:37 PM modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:39 PM 1. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:40 PM https://pubmed.ncbi.nlm.nih.gov/14663471/
Salvador sent · 6:43 PM Thank You for your feedback.
Chip & Jane sent · 6:48 PM G’nite All.. thanks for the fine discussion.
George Rovder, Arlington VA sent · 6:52 PM Thank you all. Good Night.
Salvador sent · 6:53 PM Thank You everyone, I learned a lot tonight
Terrill SF sent · 6:53 PM Thank you all. Good Night.