Editor’s Pick  The estrogen discussion is a rare topic in this forum; and, we finally pick apart IHT for one of our gents. (rd)

Topics Discussed

Estrogen and prostate cancer; 2018 denovo metastatic PCa diagnosis treated with Lupron alone; issues to raise re. Intermittent Hormone Therapy; docetaxel and HT may no longer be working; are lesions in the prostate bed considered oligometastatic disease?; Ph 1 trial experience; Jake appointed our Official Muter!; Eary success with ViewRay; Eligard vs Lupron: even after years, PSA wandering in a anarrow range well below 1.0′ Provenge.

Chat Log

AnCan – rick (to Everyone): 3:17 PM: Direct to our AnCan blog https://ancan.org/blog/

Mark Perloe (to Everyone): 3:23 PM: Does anyone.know if abiraterone has an effect on cholesterol?

Len Sierra (to Everyone): 3:25 PM: Abiraterone contributes to metabolic syndrome which raises cholesterol.

Larry Fish (to Everyone): 3:33 PM: how long for PSA fo go to 1.7 from .02 any idea of doubling time

Mark Perloe (to Everyone): 3:40 PM: Without treatment of the prostate with surgery or radiation, I find it hard to see it really go that low by just Lupron. I also wonder what tracer was used for PET scan.

Peter Kafka (Private): 3:40 PM: Has Tony had a biopsy? He did not say. Does he have a GL score? All he said was Stage 4

AnCan – rick (to Everyone): 3:41 PM: Mark ….. lupron can drive and keep it that low. We used to see that frequently Mark Perloe (to Everyone): 3:42 PM: Would he possibly benefit from radiation of prostate hoping for the abscopal effect. Would abiraterone be more appropriate than a receptor blocker?

Joel Blanchette (to Everyone): 3:43 PM: Dr. Mohammad Rahman, MD is a Medical Oncology Specialist in Steubenville, OH and has over 35 years of experience in the medical field. He graduated from Dow Med Coll medical school in 1985. He is affiliated with medical facilities East Liverpool City Hospital and Trinity Medical Center East. He is accepting new patients. Be sure to call ahead with Dr. Rahman to book an appointment.

Mark Perloe (to Everyone): 3:46 PM: FDA approved a urine liquid biopsy for prostate CA miR Sentinnel PCC4 Assay. pretty good sensitivity 94% and specificity 92%. It is used to predict presence of CA and asses the risk of high-grade tumors. Not sure I’ve seen any liquid biopsies that can be used to follow or monitor treatment.

Larry Fish (to Everyone): 3:47 PM: He is a Hemotologist

John I (to Everyone): 3:48 PM: Looks like Dr. Rahman is a generalist medical oncologist –many things conditions treated, but not PCa Ovarian Cancer Malignant Neoplasm of Female Breast, Melanoma, Non-Hodgkin’s Lymphoma, Lung Cancer, Bladder Cancer, Gastric Cancer, Hodgkin’s Lymphoma, Malignant Neoplasm of Colon, Testicular Cancer, Pancreatic Cancer. Leukemia, Rectal, Abdomen, Small Intestines, or Colon Cancer, Multiple Myeloma

John I (to Everyone): 3:48 PM: https://wb.md/3mpPxN1

Tracy Saville (to Everyone): 3:54 PM: I have to drop off, everything going well here. see you guys next week.

John I (to Everyone): 4:16 PM: I hadn’t seen the UCSF pamphlet on hormone therapy before. For anyone else who hasn’t, it’s here: https://bit.ly/2HDyhVl

Jake Hannam (to Everyone): 4:21 PM: https://ancan.org/ancan-patient-power-partner-on-advanced-prostate-cancer-webinar-series/?fbclid=IwAR1p8lai0NZ819QQxWXUMTCaYK2fyGreiT4HuLd6O5F5F4u-LZbFji5TIQE

AnCan – rick (to Everyone): 4:27 PM: https://patientpower.info/prostate-cancer/series/your-prostate-cancer-questions-answered

Jake Hannam (to Everyone): 4:37 PM: https://www.cancerabcs.org/online-support/

AnCan – rick (to Everyone): 4:38 PM: If you are failing the chemo, then a couple of strategies occur to me, Ken. 1. Rechallenge with a second line anti-androgen – either abi or a blocker 2. Switch to a different chemo combination like cabazitaxel 3. Sequence again and see if there is anything new to treat. 4. Consider a bi-specific trial … viz AmGen, Xencor, Regeneron BiTE (AMG 509) in Greensville …… ClinicalTrials.gov Identifier: NCT04221542 Xencor XmAb20717 in Charlottesville ClinicalTrials.gov Identifier: NCT03517488

Jake Hannam (to Everyone): 4:43 PM: https://prostatecancerinfolink.net/2020/10/27/sbrt-vs-ebrt-in-treatment-of-painful-spine-metastases/

Herb Geller (to Everyone): 5:01 PM: Sorry. Gotta eat dinner. See you Monday.

James Barnes (to Everyone): 5:03 PM: Good night guys! Great meeting!

Jim Ward (to Everyone): 5:04 PM: Good night, gents. Thanks for the input re intermittent ADT! The cancer center where I’m receiving Lupron in Tallahassee, FL only had a 1-month Lupron shot availble for my last shot. So, it looks like I’m going with monthly shots for now.

John I (to Everyone): 5:11 PM: Gotta run–wishing everyone a great week!

James Doyle (to Everyone): 5:12 PM: Thanks for your input and be safe. :-(])