Hi-Risk/Recurrent/Advanced PrCa Video Chat, Aug 17, 2026
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best of all our Reminders. Watch our for more details.
COMING IN SEPTEMBER… AnCan Heart Group – new support group for all things cardio and open to all! To sign up for Reminder at https://ancan.org/contact-us/. For ProsCard mailing list, please write to rd@ancan.org.
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: 1) Why are Axillary lymph nodes not considered distant? 2) Why does MSKCC prefer bone Bx?
Topics Discussed
Another low risk Gent graduates to this Group; Pluvicto cleared all but foamy gland cancer; new Sony cooling gismo; urinary blockage from RT inflammation – self catheter; surgical blood clot doesn’t rule out abi+pred but doublet not indicated; HT causes hot flashes… urgency more likely tumor – RT to start; can E2 help with hot flashes? – distracts from key Q about length of HT; moving from Lupron & abi+pred to Orgovyx+daro… is monotherapy an option?; is attending PCRI worthwhile?; Axumin shows a result – local or distant and what next?; RO at Hutch selected and VA sets up genomic tests; E2 access again – attend UCSF session; MSKCC moves off the dime to set up new doublet and Pluvicto…. but why a bone Bx?
lots of repeat information, but it does keep you up to date on any new science. I am very glad to hear you are thriving in your new home.
Gary Martin sent: 6:00 PM
Different catheter brands and diameter vary in ease-of-use and pain/irritation. I find the the Coloplast Speedicath (no-touch, hydrophillic) of smaller diameter 12 easiest.
Bill Lawler sent: 6:19 PM
Transdermal Estradiol
Gary Martinvsent: 6:32 PM
The hot flashes, I hear, interfere with sleep, which can cause the cognitive symptoms.
Bob Y — Los Angelesvsent: 6:40 PM
I need to leave early. My update was just some small detail. Thanks to all. My leg pain is indeed due to disc bulge hitting nerves and not the two ADT drugs.
Gary Martinvsent: 6:42 PM
Last year the PCRI conference was recorded and available online.
Pierre D., Olean, NYvsent: 6:54 PM
Axillary nodes should be amenable to biopsy and somatic testing
AnCan–John Avsent: 6:58 PM
“This send there is slightly prominent left axillary node with slightly increased radiotracer activity…measuring approximately 13 x 11 mm with SUV max of 5.1”
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Two (2) younger Newbies both need better QBs… AND we have another hydrocele
Topics Discussed
Agent Orange Newbie doing well on RT and doublet; younger Newbie with possible variant PrCa needs solid GU med onc; 2nd younger Newbie also needs to upgrade his MO – is he stuck in doublet?; scans suggest Jevtana not holding disease – pasritamig trial next?; debulking to start with IMRT; does coffee creamer interfere with treatment?; hydrocele not the first time for AnCan; nocturia and RT proctitis cause problems; Orgovyx coming soon; Dr. E in his future
John, thank you for the recommendation! And yes, I can get to UofC easily! I just retired…..lots of free time!
Don Rogers sent: 4:08 PM
Hi John, Nice to hear you are doing well. Everything here in Boca Raton is also wonderful. I am doing great, PSA still undetectible. Looking forward to going on a Disney Cruise with the entire family in early July. Mary and I then go on a 10 day camping trip to Yellowstone. Let me what you find out at your 3 month visit with your oncologist. My best always, Don
Len Sierra sent: 4:21 PM
EZH2 inhibitors: Mevrometostat (PF-06821497): An investigational selective inhibitor of enhancer of zeste homolog 2 (EZH2) being studied in combination with XTANDI for mCRPC. Several Phase 3 trials (MEVPRO-1 and MEVPRO-2) are ongoing.
Bob McHugh sent: 4:49 PM
Lomotil or Immodium?
Jim Ekrut, Ft. Worth, TX sent: 4:51 PM
Imodium doesn’t seem to help much. I’m hoping the gastroenterologist will prescribe Lomotil, but he initially hesitated because it’s a controlled substance.
Jim Marshall, Vet Sup Grp. Moderator sent: 4:56 PM
The LATITUDE Trial, 2017, had HS Abi + 10mg. and a few years later HS dropped to 5mg although CR stayed at 10mg. Jim M
Jim Ekrut, Ft. Worth, TX sent: 5:04 PM
Thanks so much for a helpful session! Until next time.
Hi-Risk/Recurrent/Advanced PrCa Video Chat, 5/4/26
Survey Opportunity
$200 for a 60min interview. Must be mHSPC or mCRPC; 40-75+/-; NOT have used Talzenna, Xtandi or Orgovyx. Reach out to Jason at 773 383 9090 jturner@flinceresearch.com. 15 needed. Indicate you are via AnCan and let us know if accepted (rd@ancan.org)
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Mutation issues prevail tonight… but also 1.4 PSA on mono daro raises questions.
Topics Discussed
Does PTEN change HT duration?; low/intermediate Gent sneaks in; gynecomastia prevention; is a 1.4 PSA on mono daro good or bad?; 2nd opinion for another PTEN Gent; BRCA Gent finds new lead GU MO; HIFU for recurrence within prostate; bad reaction to first chemo; PSA rises 4x in 3 months; younger Newbie follows triplet against TP53 and PTEN
Chat
AnCan – Rick sent: 4:53 PM
Flince survey…. NO Talzenna, Xtandi or Orgovyx JTurner@flinceresearch.com
40-75 +/- metastatic
AnCan–John A sent: 5:42 PM
germline (inherited) gene test
AnCan–John A sent: 5:44 PM
Dr Epstein: advanceduropathology.com (516)280-7930
Don Rogers sent: 6:06 PM
anastrozole 1 mg twice a week
Len Sierra sent: 6:24 PM
The only study I’m aware of was the EMBARK trial with 3 arms: ADT alone, Enzalutamide alone, and combo of enzalutamide and ADT. Read about that trial.
Richard B, Silver Spring, MD sent: 6:31 PM
I need to step away to take a phone call. I appreciate the efforts of the AnCan team for their efforts to this evening’s discussion.
AnCan–John A sent: 6:33 PM
cabazitaxel Jevtana
AnCan Bill sent: 6:34 PM
Frank is still on. Just not in front of his camera right now.
Bruce Schrimpf sent: 6:59 PM
Thanks guys! As always good!
Jim Marshall, Vet Support Grp. Moderator sent: 7:03 PM
Another Trial for PTEN for mCRPC is being run by the VA and GW Hospital called the Carpet Trial. Jim M
“Thomas” Matica sent: 7:03 PM
Good night, gents. Very good meeting and many thanks to our great moderators
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: AnCan’r considering AMG509 STEAP T-Cell engager; does IDC-P make you high risk?
Topics Discussed
Newbie needs GU MO and doublet; ADT and heart issues; BRCA2 germline Gent progresses after RP; no evidence for doublet; long-timer needs to switch treatment; moving from Pluvicto to xaluritamig/ AMG509/ STEAP trial; supplemental E2 discussed by peer – insurance issues, gui9dance on E2 blood levels; IDC-P man on RT asks how much HT; with BCR, doubling time may be more significant guide to BCR than actual PSA level
Chat
Jim Marshall, Vet Support Grp. Moderator sent: 6:33 PM
Joining from the air. No mic available. I just blogged the Estradiol conversation.
AnCan – Rick sent: 7:36 PM
Kishan would say 6 months per his recent meta study
Show Tran the Kishan paper
Jeff Marchi – San Francisco sent: 7:37 PM
has he had genetic testing? it can frequently be associated with genetic issues
AnCan – Rick sent: 7:37 PM
12 months if you’re more aggressive.
Is Spratt the final author
Steve Schuler (Seattle) sent: 7:40 PM
I just wrapped it up a month ago. Now I’m on nothing, no ADT either. I was on Lupron for 2 years, abiraterone also for 2 years, but started a year after the Lupron started (there’s a story there, but later), and then on Estradiol for most of the time I was on abiraterone. But now on nothing. For most of the E2, it was .05mg (50 microgram) patches 2 per week. So a box of 8 lasts you 4 weeks. With GoodRX, those were $13/box
A word about the dose level of the patches: that’s the estimated dose delivery of a patch per day. The amount of E2 in the patch itself is higher, something like 600 microgram is what I remember, but then it releases slowly at an ESTIMATED rate of 50. But that release rate is highly dependent on the amount of fat under the skin, etc. So your milage will vary
Mark N sent: 7:44 PM
Thanks for the feed back!
dan-s alexandria sent: 7:48 PM
thanks Jimmy
Pierre D., Olean, NY sent: 7:52 PM
Thank you all for your input.
Jeffrey G sent: 7:53 PM
We were in the 90s today. Ugh, warmest AZ winter i’ve ever been in. Still, gotta be grateful for warm weather and for a psa of 0.02…Adios
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Cribriform complicates treatment decision; and we discuss NCI trial
Topics Discussed
Over-70 KP ‘Couple’ insisted on PSA against protocol and found 4+4 cancer – cribriform complicates Tx decision; recently Dx denovo Mx ‘Couple’ seeking their way; recurrence after 7 years may set up well for NCI trial; high Decipher and cribriform may point to doublet; NCI Playing the Long Game discussed – Dr. Paul rightly finds it antithetical; Natera trial result reports zero level ctDNA; leg pain after starting doublet HT; push the IHT 3 more months with diligent AS; estradiol vets defer conversation to next week; side effects of radiation treatment
Is Gallium – 68 the more sensitive recommended radioactive tracer to use for a PSMA-PET Scan? Just wondering if seeking the best tracer produces better results.
