AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Novartis, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime!
Editor’s Pick: What do medical medical marijuana and estradiol (E2) have in common? … cardiovascular risks (rd)
Topics Discussed
Is this Newbie getting enough radiation for his high risk situation?; darolutamide monotherapy or maybe a drug holiday?; ARX517 trial – PSMA antibody drug conjugate that carries cytotoxic payload; addressing sleep issues; otc CBN; medical marijuana comes with cardiovascular risks; switching your provider for cause; estradiol and phytoestrogens; early success with AR degrader ARV766; delaying Pluvicto #3 and considering PARP-i; is it a flare or progression?; fenbendazole
Chat Log
Jim Marshall, Alexandria, VA
sent: 3:23 PM
If anyone is facing Open Heart Surgery contact me and I can give you somethings the Surgeon might not mention. Jim 703-338-7341
Jim Marshall, Alexandria, VA
sent: 3:30 PM
Janssen also makes a Generic version oof Abiraterone (ZYTIGA). Have taken it as a generic
After being on Eligard + Abi for 5 years, it took 13 months to recover any testosterone after being on the 2 drugs for 5 yrs. a 90-day Eligard shot can last much more than 90 days
Hi-Risk/Recurrent/Advanced PCa Video Chat, April 1, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
View AnCan’s patient-centered selection of papers and presentations from ASCO GU 2024, one of the top conferences on prostate cancer treatment: • ASCO GU 2024 conference highlights https://www.youtube.com/watch?v=YweU8hjA0Lw&t=2s
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Androgen Receptor degrader ARV766 arrives ahead of its webinar later this year (rd)
Topics Discussed
Diagnosed at 52 and concerned about recurrence at 61; pulse and bloods back to normal – was it the RT?; Metastatic Directed Therapy is not for everyone; starting AR degrader ARV766 trial; issues arising from RT proctitis and hemorrhoids; military vs civilian medical care; questioning pembrolizumab and its toxicity with TMB of 8.6?; abscopal effect from RT with Keytruda
Prednisone raises neutrophils and lowers lymphocytes. Par for the course with taking prednisone. My neutrophils are high and lymphocytes are low. Still on it Been on it for 8 months. When it is stopped the numbers should return to normal
Bob G
sent: 6:28 PM
slow creep is good!
sent: 6:29 PM
Our hearts are with you Dr. Bob
Chas Ryan
sent: 6:33 PM
Thank all of you for sharing this evening. Bob G, good luck with your treatment. I have to depart the meeting. Until next week,…
Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 19, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
darolutamide achieves undetectable status after many years; should he radiate L4 – ask his QB!; PSMA scans at low PSA levels; intermittent hormone therapy requires active surveillance… and anxiety for some; Ac225 Tx in Austria followed by Ac225+Lu177 and a PARP with no HRR mutation; another Gent remains undetectable; no evidence of PCa from scans but inferior blood counts; Newbie at the back end – 20 year survivor finally requires 2nd line anti-androgen
Even though I have been on Treatment Holiday for 21 months I still get my PSA and testosterone blood test every month. I feel like I am then proactive. jim Marshall
Jerry Grimes, Brighton, MI
sent: 6:55 PM
Hey all, gotta run. All the best!
Peter Kafka – Maui
sent: 7:08 PM
With all this movement in the nuclear medicine field, are there specialized Nuclear Oncologists now working at Centers of Excellence or is much of this being managed by GU Med Oncs or Radiation Oncs?
Len Sierra
sent: 7:09 PM
Peter, in many instances, nuclear medicine specialists are used.
Len Sierra
sent: 7:19 PM
The European Medicines Agency (EMA) is the European Union’s (EU) equivalent to the FDA. The EMA is a decentralized agency located in Amsterdam, Netherlands, that evaluates, supervises, and monitors the safety of medicines for humans and animals in the EU and the European Economic Area (EEA). The FDA and the EMA work together to streamline efforts, share best practices, and promote human and animal health.
Len Sierra
sent: 7:40 PM
From Johns Hopkins: Blood cells are made in the bone marrow. The bone marrow is the soft, spongy material in the center of the bones. It produces about 95% of the body’s blood cells. Most of the adult body’s bone marrow is in the pelvic bones, breast bone, and the bones of the spine.
Hi-Risk/Recurrent/Advanced PCa Video Chat, Nov 20, 2023
HAPPY THANKSGIVING TO ALL OUR VIEWERS… may it be peaceful and full of gratitude.
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Persevere to the very end to hear us question docs who recommend Pluvicto knowing some mets won’t respond (rd)
Topics Discussed
Different MRI presentations can confuse; balance and falling; do dormant prostate cells express PSMA?; Pluvicto offers no quick result – Ac225 next??; don’t rush the prednisone taper; does your assigned doc have the right qualifications?; urinary issues lead to kidney failure – and a neck brace!; Orgovyx causes fewer hot flashes for some men; with mCRPC, don’t anguish over 0.1-0.3 PSA fluctuations; do historic doubling patterns hold when PCa recurs?; PCa recurs only IN the radiated gland – what next after 6 mo. HT?; ultra sensitive test redundant post-RT; does Pluvicto make sense for man with hybrid PCa?
Chat Log
Michael Wyn, Denversent · 6:15 PM
Thanks everyone. Good bye
Phil Dipaolasent · 6:19 PM
Hi, I would like a few minutes during the session today, if possible! Thanks, Phil Dipaola
sent · 6:21 PM
Phil – you have to be here in the first 10 minutes to be sure of time. PLEASE REFER TO OUR REMINDER. That’s the protocol with so many attendees.. If we have time at the end, we’ll certainly get to you.
sent · 6:22 PM
Were you tested for neuropathy?
Bill Franklinsent · 6:31 PM
Joel, if at all possible, don’t hesitate to ask for a physical therapy referral from your PCM. All the stuff Larry talked about would be worked on.
Bill Franklinsent · 6:37 PM
What age is considered elderly now? This is a serious question. Sometimes all doctors think about is the number on the age line. But many of us are in great shape.
TonyFigsent · 6:39 PM
I thought the Surf sound in Florida got louder in the winter. Maybe it is elderly shuffling their feet.
AnCan – ricksent · 6:52 PM
Google …… Alpha emitter vs Beta emitter PSMA radionuclide therapeutics
I will. turn 75 tomorrow, and I do not consider myself elderly!
My wife was a geriatric nurse. She had no time for doctors who blamed problems on an individual’s age.
AnCan – ricksent · 7:10 PM
Happy B-day to Alan Babcock!!!
JEFFERSONsent · 7:11 PM
thank you so much
Julian – Houstonsent · 7:14 PM
Happy B-day Alan!!!
Jimmy Greenfieldsent · 7:20 PM
Biological age , not the number. In my parent’s time 70 was elderly. People stopped moving. I know otherwise ‘healthy”50 year olds who are truly old, physically and/or behaviorally. Unfit, set in their ways etc. Then you have birthday boy Alan Babcock- 75 years young if ever I saw it.
sent · 7:21 PM
Hi I have a question about PSA test sensitivity. For the first time in about 6 months my level went below the ‘undetectable’ level as my local Kaiser defines it, <.06. Very grateful for that. Going forward, I’m wondering if I should be pushing Kaiser for a test with greater sensitivity? When people talk about their PSA testing I usually hear specificity below .06, but I’m not sure if there would be value for me in that ‘extra’ sensitivity. I am 3.5 years past initial radiation treatments not taking any medications at this point.
Alan Babcocksent · 7:22 PM
Thanks Jimmy
Jim Marshall, Jupiter, FL on Vacsent · 7:26 PM
You say not under treatment but have you been not being treatec for 3.5 yrs or on a treatment holiday. I’d press for PSA tests every 4 months. I am Kaiser too. but on treatment holiday gettng PSA test every month.
sent · 7:34 PM
Thank you Jim Marshall for the question; after radiation I did 2 years of Zytiga/prednisone, and haven’t yet had the need to restart.
Jim Marshall, Jupiter, FL on Vacsent · 7:36 PM
uugst PSA test ever 1-2 months because you are on holiday. In fact I get all the blood tests I got when under treatment. Kaiser has no problem with in in the DC area.
Jim Marshall, Jupiter, FL on Vacsent · 7:38 PM
although if the thought is you are in remission, then 3 months for a year and then either every 4 or 6 months going forward not needing all the other tests. Jim M
sent · 7:41 PM
Thank you Jim M!
Alan Msent · 7:46 PM
Matt, I have had the ultrasensitive PSA test done by Labcorp for 10 years. I prefer to see small changes and get an early warning of pending increases or decreased in PSA. I recommend it as long as it won’t give you anxiety.
Julian – Houstonsent · 7:47 PM
I am also doing the ultrasensitive PSA test every 3 months!
Alan Msent · 7:52 PM
Need to sign off guys. Good night.
Jim Marshall, Jupiter, FL on Vacsent · 8:03 PM
Kaiser has always given me PSA tests with 2 decimal places from the start 6.25 years ago. It has been less than 0.01 ever since I was on ABI + Lupron and into 15 months holiday.
Hi-Risk/Recurrent/Advanced PCa Video Chat, Oct 10, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
UPCOMING WEBINAR – Let’s talk Medicare 2024!Monday, Oct 30 8.00 pm Eastern Register at http://tinyurl.com/ancanmedicare . We plan NOT to make this scary!!!
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s pick:Does it make sense to keep your cancer off guard?… & the Group talks A-fib! (rd)
Topics Discussed
AnCan loses two long term men on same day; Zometa side effects; 3+3 (??) newbie addresses mets after 20 years; Gent running out of options needs current sequencing … and new doc; does it make sense to keep the cancer off guard?; addressing A-fib; reducing visceral fat with exercise addresses sarcopenia; darolutamide refused so Gent starts with Orgovyx alone; Payer wrongly refusing NGS somatic testing; blood in urine could be RT cystitis – cystoscopy required; PCa recurs only within the gland.
Chat Log
Matt Kriegersent · 3:32 PM
Here are my recent PSA trends, it’s been a bit of a rollercoaster and I would appreciate any feedback. My treatment history is external radiation and HDR brachytherapy completed April 2020, and I was on 2 anti-androgens until June 2022. So 9 (Sept.)/2022 <.06, 1/2023 .06, 3/2023 .06, 6/2023 .35, 7/2023 .17, 8/23 .24, 9/2023 .07 I’m seeing my urologist tomorrow because a few weeks ago, for the only time other than the one biopsy and brachy, I had some blood in my urine – that was surprising but hasn’t happened again since.
sent · 3:35 PM
Too many things to do. You need to talk with the group. You need to make changes now.
Jim Marshall, Alexandria, VAsent · 3:44 PM
Genitourinary Medical Oncologist
John Asent · 3:48 PM
“LHRH antagonist drugs include relugolix (Orgovyx) and degarelix (Firmagon). These will suppress testosterone rapidly and don’t need the premedication with another drug.
Jim Marshall, Alexandria, VAsent · 3:50 PM
Abiraterone for Castration-Sensitive guys is 5MG of Prednisone
John Asent · 3:50 PM
Then, a second dug may be added to add to the testosterone suppression: abiraterone or darolutamide or enzalutamide.
marc valenssent · 3:56 PM
genitourinary MedOnc at Fred Hutchinson in Seattle: Petros Grivas
J. Wardsent · 4:00 PM
I need to hop off now; thanks for allowing me speak about Ken Anderson.
