AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Dr. Paul provides sage advice more than once but can’t prevent his E2 getting aced out by Veozah!
Topics Discussed
Treatment decision for newly Dx high risk, 72 yr old Newbie; Dr. Paul has thoughts on RT vs surgery; one of our Mods faces Tx decision for a single lymph node lesion; Dr. Paul comments further on surgical removal and also nerve sparing surgery; darolutamide and fatigue; urinary issues post-RT; Andromeda trial completed with a few more side effects; T comes back and PSA stays low post RT + HT; getting off daro to stay in ‘The Long Game’ study; should denosumab be capped off with a bisphosphonate/; considering the LEGION-100 SYNC-T trial… again; Veozah works a charm
Coordinator for Andromeda Trial Sophia Parmisano (she/her) Clinical Research Coordinator UCLA Dept. of Radiation Oncology Ph: (310) 267-3169 200 Medical Plaza, Suite B265 Los Angeles, CA 90095-6951
Bruce C sent: 5:27 PM
legion 100
Len Sierra sent: 5:27 PM
LEGION-100 Clinical Trial ClinicalTrials.gov ID Number: NCT06533644 This clinical trial is studying an investigational therapy called SYNC-T Therapy SV-102. It is a combination therapy that freezes a portion of a tumor and then infuses a drug directly into the tumor. The therapy is designed to activate the immune system and enable it to fight cancer throughout the body.
rick davis sent: 5:35 PM
Sat Sep 19h High Risk/Rec/Adv PrCa. Reminder…. The Abscopal Effect Done with Class!
Mark sent: 5:52 PM
Not tonight, thanks
Lymph node was not accessible
Danny Lankford sent: 5:54 PM
I will receive monthly liver enzyme testing
Bruce Schrimpf sent: 5:54 PM
Great session guys! I found it very good this evening!
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Oct. 27, 2026
AnCan WEBINAR Thu. Oct, 29 @ 8pm Eastern -” What’s new in radioligand therapy… and how to access it” w. Drs. Mike Hofman and Frankis Almaguel. Register https://short.do/jFCa8I
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Should minor presence of neuroendocrine cancer from lymph biopsy be a concern? And of course Dr. Paul on NCCN’s E2 approval
Topics Discussed
Inherited mutation makes RRP follow up protocol less clear; what comes after success with triplet but what comes next?; GG5 Newbie does 24 months doublet and wants to know likelihood of recurrence; Ki67 indicates slight presence of neuroendocrine cancer – implications; creatine helps with muscles and fatigue; leg lymphedema bothersome; is E2 available with salvage RT; how quickly does T return with E2; talking NCCN E2 approval with Dr. Paul; can E2 replace Prolia?; over-intensification may have caused heart issues; addressing hot flashes; maintaining exercise in the face of doublet HT; octogenarian does well post triplet and drug holiday; with 2+ bad boy mutations, who’s the best GU med onc to QB care?
Thank you for your help and input. I need to go, but look forward to connecting in the future.
Brian Haack – Eagle, ID sent: 4:28 PM
How long after drug holiday (9 months ADT doublet tx) should I wait until getting blood work? I’m on my 2nd recurrence btw. Don’t want to interrupt the great dialogue
Jim Marshall, Vet Sup Grp. Moderator sent: 4:32 PM
I get blood work every month now for 9+ years, the last 4+ years on Holiday. Kaiser permits it. Hopefully getting PSA test during the holiday to know when it starts to rise.
George Kander sent: 4:32 PM
thanks guys i have to go. see you next week
Len Sierra sent: 4:45 PM
Just a counter opinion: Clinical trials in patients with colorectal or prostate cancer found that creatine supplements generally failed to improve muscle mass, physical function, or quality of life during treatment.
Sam Kaufman (Oakland CA) sent: 4:47 PM
Sorry I cant stay until Im called. My questions can wait two weeks.
Jim Ekrut, Fort Worth TX sent: 5:03 PM
Thanks for another helpful and informational session!
Brian Haack – Eagle, ID sent: 5:05 PM
Gotta bounce… great discussion
TonyFig sent: 5:07 PM
Great meeting. See you next week
Frank D sent: 5:18 PM
Thanks for great meeting. Very helpful!
Bob Schwartz, USN, Venice, FL. sent: 5:19 PM
Another good mtg., have to go.
“Thomas” Matica sent: 5:21 PM
Great meeting. Dinner is on the table. Next time. Peace.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: E2 doublet discussion – closely followed by integrating psilocybin into HT doublet!
Topics Discussed
Newbie diagnosed 4 years back with PSA @ 4000 & BRCA+ might consider a different doublet -or PARP; Newbie responds but has 4 consecutive negative PSMA scans – consider Axumin; could E2 doublet be an option?; PTEN just indicated; 2 negative Bx confirm our hunch Gent is Mx ; can experienced user integrate psilocybin into his HT to treat depression; monotherapy daro works exceptionally well – but must make decision on ‘Long Game’ trial; how long to stay on mono daro?; 1st Pluvicto rings PSA down a little – what to expect next?; Dr. Guancial uses fewer tests making Gent anxious – T/W her!
I want to ask Dr A if I can do the psilocybin therapy again while receiving radiation
Bob Schwartz, USN, Venice, FL. sent: 6:33 PM
Danny, we’re all here for you brother.
Gary Martin sent: 6:42 PM
RT can impact bone marrow–lowering blood counts and possibly increasing fatigue. This happened to me–lowering blood counts further to below-normal–on top of impact of triplet prior to RT.
Read that ice packs have been shown to limit the effects of Pluvicto on salivary glands–study in Europe. Don’t have a reference to study yet.
Hank Zajic Springfield VA sent: 7:10 PM
Good night all. Thank you for the discussion. out of battery here. Hank
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Sep 21, 2026
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best from our Reminders and Blog Posts. Watch our for more details.
NEW AnCan HEART Group for all things cardio.Sign up for Reminder at https://ancan.org/contact-us/. For ProsCard mailing list, please write to dr.john@ancan.org to be added to the distribution and Dr. John’s weekly heart primer.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Go to ‘Extra Time’ to hear Newbie with PTEN, TP53 and maybe RB1
Topics Discussed
denovo N1 Newbie waits on treatment recommendations; uro assumes Newbie is denovo M1 but SUV is low – needs verification; T rises but PSA holds steady – CRPC??; offered Veozah trial – but hide the Embr watch; PSA increases from 0.16 to 1.6 – could be inflammation or RT; insist on a bone strengthener and switch docs; at least 12 m. of doublet; Reel Recovery rave review; arousal 3 months after stopping org, but Gent expects more; late Newbie faces PTEN, TP53 and possibly RB1 – treatment path???
Chat
Sergio sent: 5:41 PM
David – ty for your message. Let’s def connect. I can be reached at gonzaler84@hotmail.com. We can find time later in the week if this works for you.
Bill Lawler sent: 6:09 PM
When i was prescribed those two drugs, I was advised to stagger the start dates by ten days to two weeks.
FEZOLINETANT
Avery sent: 6:35 PM
Bill Lawler – Are you in the DMV area? If so, which hospital is your care? FYI- I just received the exact same markers and barrigel and I start my 5 and half weeks of radiation treatments on Wed at Sibley.
ok thx
Bill Lawler sent: 6:41 PM
Avery, My 28 treatments start on Oct. 1. Greater Boston area, MGB Danvers.
Avery sent: 6:41 PM
Bill – Wish you well
Bill Lawler sent: 6:49 PM
Fezolinetant principal investigator: Shehzad Basaria, Brigham & Women’s Hosp.
Bob Schwartz, USN, Venice, FL. sent: 7:08 PM
Another good mtg., have to go, see everyone next mtg.
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Sep 1, 2026
Are you in DelMarVa?? Reserve Wednesday night, Sep 16 for an AnCan get-together. We’ll meet for a ‘dutch’ dinner in the Chevy Chase area – location TBD. If you have not received an email invitation and would like to attend, please drop a note to boykin@ancan.org. Partners/spouses welcome!
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best of all our Reminders. Watch our for more details.
COMING IN SEPTEMBER… AnCan Heart Group – new support group for all things cardio and open to all! To sign up for Reminder at https://ancan.org/contact-us/. For ProsCard mailing list, please write to dr.john@ancan.org.
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: 1) when your pituitary goes dormant 2) is debulking the primary right?
Topics Discussed
Stable disease but treatment leads to one atrophied kidney; is a GU med onc needed at this juncture?; pituitary never recovered post prednisone/abi – what next?; pros and cons of RT debulking for higher volume denovo Mx Gents; Tony Fig’s shoulder surgery; RT cystitis causes hospitalization and deferral of clinical trial; is Testosterone replacement appropriate?; heart issues defer advocating for a PSMA update
Chat
Pierre D., Olean NY sent: 3:11 PM
$50 \hr
Alfredo in Wimberley, TXsent: 3:55 PM
gadolinium
jeff wood sent: 4:04 PM
What are the repercussions of debulking?
RJ Smith (Seattle) sent: 4:07 PM
Standard side-effects and long-term risks of side-effects from the radiation.
Len Sierra sent: 4:20 PM
The Bardo Thodol – Tibetan Book of the Dead — kudos to Dr. John!
