AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Dr. Paul provides sage advice more than once but can’t prevent his E2 getting aced out by Veozah!
Topics Discussed
Treatment decision for newly Dx high risk, 72 yr old Newbie; Dr. Paul has thoughts on RT vs surgery; one of our Mods faces Tx decision for a single lymph node lesion; Dr. Paul comments further on surgical removal and also nerve sparing surgery; darolutamide and fatigue; urinary issues post-RT; Andromeda trial completed with a few more side effects; T comes back and PSA stays low post RT + HT; getting off daro to stay in ‘The Long Game’ study; should denosumab be capped off with a bisphosphonate/; considering the LEGION-100 SYNC-T trial… again; Veozah works a charm
Coordinator for Andromeda Trial Sophia Parmisano (she/her) Clinical Research Coordinator UCLA Dept. of Radiation Oncology Ph: (310) 267-3169 200 Medical Plaza, Suite B265 Los Angeles, CA 90095-6951
Bruce C sent: 5:27 PM
legion 100
Len Sierra sent: 5:27 PM
LEGION-100 Clinical Trial ClinicalTrials.gov ID Number: NCT06533644 This clinical trial is studying an investigational therapy called SYNC-T Therapy SV-102. It is a combination therapy that freezes a portion of a tumor and then infuses a drug directly into the tumor. The therapy is designed to activate the immune system and enable it to fight cancer throughout the body.
rick davis sent: 5:35 PM
Sat Sep 19h High Risk/Rec/Adv PrCa. Reminder…. The Abscopal Effect Done with Class!
Mark sent: 5:52 PM
Not tonight, thanks
Lymph node was not accessible
Danny Lankford sent: 5:54 PM
I will receive monthly liver enzyme testing
Bruce Schrimpf sent: 5:54 PM
Great session guys! I found it very good this evening!
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Does the PROTEUS trial (RRP + doublet) set a good example?
Topics Discussed
Does surgery with doublet (PROTEUS trial) make sense for 72 yr old; Dana Farber visit raises questions about ‘diffuse’ cells and PSMA tracer agents; sensitive PSA test needed post surgery; VA approves daro but too early for Truqap; hormone resistance post triplet raises RLT vs chemo vs ???; Cu67 SAR-bisPSMA alternative to Pluvicto; switch to local GU PSMA for ease of treatment; small peritoneal lesions double in size to 4mm over 5 years – treat or not?; drug holiday success – PSA declines and T rises 🎉
Chat
Carl – Indiana sent: 6:12 PM
Tin Caps are welcome
Len Sierra sent: 6:40 PM
I’m at my son’s house in Maryland using his computer. Not sure what’s going on. I’ll just listen
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Oct. 27, 2026
AnCan WEBINAR Thu. Oct, 29 @ 8pm Eastern -” What’s new in radioligand therapy… and how to access it” w. Drs. Mike Hofman and Frankis Almaguel. Register https://short.do/jFCa8I
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Should minor presence of neuroendocrine cancer from lymph biopsy be a concern? And of course Dr. Paul on NCCN’s E2 approval
Topics Discussed
Inherited mutation makes RRP follow up protocol less clear; what comes after success with triplet but what comes next?; GG5 Newbie does 24 months doublet and wants to know likelihood of recurrence; Ki67 indicates slight presence of neuroendocrine cancer – implications; creatine helps with muscles and fatigue; leg lymphedema bothersome; is E2 available with salvage RT; how quickly does T return with E2; talking NCCN E2 approval with Dr. Paul; can E2 replace Prolia?; over-intensification may have caused heart issues; addressing hot flashes; maintaining exercise in the face of doublet HT; octogenarian does well post triplet and drug holiday; with 2+ bad boy mutations, who’s the best GU med onc to QB care?
Thank you for your help and input. I need to go, but look forward to connecting in the future.
Brian Haack – Eagle, ID sent: 4:28 PM
How long after drug holiday (9 months ADT doublet tx) should I wait until getting blood work? I’m on my 2nd recurrence btw. Don’t want to interrupt the great dialogue
Jim Marshall, Vet Sup Grp. Moderator sent: 4:32 PM
I get blood work every month now for 9+ years, the last 4+ years on Holiday. Kaiser permits it. Hopefully getting PSA test during the holiday to know when it starts to rise.
George Kander sent: 4:32 PM
thanks guys i have to go. see you next week
Len Sierra sent: 4:45 PM
Just a counter opinion: Clinical trials in patients with colorectal or prostate cancer found that creatine supplements generally failed to improve muscle mass, physical function, or quality of life during treatment.
Sam Kaufman (Oakland CA) sent: 4:47 PM
Sorry I cant stay until Im called. My questions can wait two weeks.
Jim Ekrut, Fort Worth TX sent: 5:03 PM
Thanks for another helpful and informational session!
Brian Haack – Eagle, ID sent: 5:05 PM
Gotta bounce… great discussion
TonyFig sent: 5:07 PM
Great meeting. See you next week
Frank D sent: 5:18 PM
Thanks for great meeting. Very helpful!
Bob Schwartz, USN, Venice, FL. sent: 5:19 PM
Another good mtg., have to go.
“Thomas” Matica sent: 5:21 PM
Great meeting. Dinner is on the table. Next time. Peace.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Do you get PSMA PET after doublet then how often?; and, how to say Guancial!
Topics Discussed
Younger Newbie graduates to our Group post RRP; treated after 20 yrs of AS.. but in the wrong group; finding the best trial for Frank; Bx cannot confirm PrCa; spot RT may be the ticket; all sable during IHT; RT to commence this month; what’s in Dr. Guancial’s name?; PSMA scans pos doublet are negative; when and how often to PSM scan; GU MO denies Pluvicto post triplet though scans light up; Gent decides to start TRT; brief discussion of HLD-0915
Chat
Bob Schwartz, USN, Venice, FL. sent: 3:17 PM
I can agree as to the hospital sling I received last time, for my other shoulder surgery. Which was why I was glad to hear your recommendation of a better one, prior to my upcoming surgery. Wish I didn’t need the surgery, but old age & past injuries, are catching up with me.
Steve L…. Hold tight and we’ll have the mugs available in our shop before long. You can order and take care of biz.
Alfredo in Wimberley, TX sent: 4:31 PM
Family calling – I must drop off now. Best wishes to all!
Steve Schuler (Seattle) sent: 4:31 PM
I wondered why I hadn’t heard anything… Answer: beurocrac
(can’t spell it though… :^(
Len Sierra sent: 4:36 PM
JAMA Oncol. 2019, 5, 856-863. In the first prospective trial of 68Ga-PSMA-11 PET/CT for BRPC, which included 635 patients, detection rates were 38% for PSA levels of < 1.0 ng/mL (n = 79), 84% for 1.0 to 2.0 (n=89), 86% for 2.0 to 5.0 (n=158), and 94% for >5.0. (BRPC = Bio-Recurrent PC)
Steve Schuler (Seattle) sent: 4:41 PM
a meta-observation is that most therapies that are initially only for end stage move earlier in treatment where their use there improves things. improves at least in the CSS sense, not necessarily in the OS sense
Len Sierrasent: 4:46 PM
New Terminology: • Androgen Pathway Modulator Sensitive: Tumors that continue to respond to or are controlled by androgen pathway suppression/blockade. • Androgen Pathway Modulator Resistant: Tumors that progress despite treatment targeting the androgen pathway
Steve – Seattle sent: 4:49 PM
My Calendar has the Ancan Seattle dinner scheduled for Sunday but I don’t have any details.
rick davis sent: 4:51 PM
Stand by as I said.
Steve Schuler (Seattle) sent: 4:53 PM
I’ve got to drop, but I will “stand by” to hear about Sunday. I will be at the conference Saturday, probably at Fred Hutch which I assume must be a video screen but in the FH building… That way I get a free sandwich I think :^)
RJ Smith (Seattle) sent: 4:54 PM
Same here–see you there Steve!
rick davis sent: 4:54 PM
: NCT06800313 HLD0915
George Kander
sent: 4:56 PM
Family calls – have to go. Thanks everyone and hopefully see you at dinner Friday in Portland – Chhers
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Sep 21, 2026
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best from our Reminders and Blog Posts. Watch our for more details.
NEW AnCan HEART Group for all things cardio.Sign up for Reminder at https://ancan.org/contact-us/. For ProsCard mailing list, please write to dr.john@ancan.org to be added to the distribution and Dr. John’s weekly heart primer.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Go to ‘Extra Time’ to hear Newbie with PTEN, TP53 and maybe RB1
Topics Discussed
denovo N1 Newbie waits on treatment recommendations; uro assumes Newbie is denovo M1 but SUV is low – needs verification; T rises but PSA holds steady – CRPC??; offered Veozah trial – but hide the Embr watch; PSA increases from 0.16 to 1.6 – could be inflammation or RT; insist on a bone strengthener and switch docs; at least 12 m. of doublet; Reel Recovery rave review; arousal 3 months after stopping org, but Gent expects more; late Newbie faces PTEN, TP53 and possibly RB1 – treatment path???
Chat
Sergio sent: 5:41 PM
David – ty for your message. Let’s def connect. I can be reached at gonzaler84@hotmail.com. We can find time later in the week if this works for you.
Bill Lawler sent: 6:09 PM
When i was prescribed those two drugs, I was advised to stagger the start dates by ten days to two weeks.
FEZOLINETANT
Avery sent: 6:35 PM
Bill Lawler – Are you in the DMV area? If so, which hospital is your care? FYI- I just received the exact same markers and barrigel and I start my 5 and half weeks of radiation treatments on Wed at Sibley.
ok thx
Bill Lawler sent: 6:41 PM
Avery, My 28 treatments start on Oct. 1. Greater Boston area, MGB Danvers.
Avery sent: 6:41 PM
Bill – Wish you well
Bill Lawler sent: 6:49 PM
Fezolinetant principal investigator: Shehzad Basaria, Brigham & Women’s Hosp.
Bob Schwartz, USN, Venice, FL. sent: 7:08 PM
Another good mtg., have to go, see everyone next mtg.
