AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: E2 doublet discussion – closely followed by integrating psilocybin into HT doublet!
Topics Discussed
Newbie diagnosed 4 years back with PSA @ 4000 & BRCA+ might consider a different doublet -or PARP; Newbie responds but has 4 consecutive negative PSMA scans – consider Axumin; could E2 doublet be an option?; PTEN just indicated; 2 negative Bx confirm our hunch Gent is Mx ; can experienced user integrate psilocybin into his HT to treat depression; monotherapy daro works exceptionally well – but must make decision on ‘Long Game’ trial; how long to stay on mono daro?; 1st Pluvicto rings PSA down a little – what to expect next?; Dr. Guancial uses fewer tests making Gent anxious – T/W her!
I want to ask Dr A if I can do the psilocybin therapy again while receiving radiation
Bob Schwartz, USN, Venice, FL. sent: 6:33 PM
Danny, we’re all here for you brother.
Gary Martin sent: 6:42 PM
RT can impact bone marrow–lowering blood counts and possibly increasing fatigue. This happened to me–lowering blood counts further to below-normal–on top of impact of triplet prior to RT.
Read that ice packs have been shown to limit the effects of Pluvicto on salivary glands–study in Europe. Don’t have a reference to study yet.
Hank Zajic Springfield VA sent: 7:10 PM
Good night all. Thank you for the discussion. out of battery here. Hank
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Do you get PSMA PET after doublet then how often?; and, how to say Guancial!
Topics Discussed
Younger Newbie graduates to our Group post RRP; treated after 20 yrs of AS.. but in the wrong group; finding the best trial for Frank; Bx cannot confirm PrCa; spot RT may be the ticket; all sable during IHT; RT to commence this month; what’s in Dr. Guancial’s name?; PSMA scans pos doublet are negative; when and how often to PSM scan; GU MO denies Pluvicto post triplet though scans light up; Gent decides to start TRT; brief discussion of HLD-0915
Chat
Bob Schwartz, USN, Venice, FL. sent: 3:17 PM
I can agree as to the hospital sling I received last time, for my other shoulder surgery. Which was why I was glad to hear your recommendation of a better one, prior to my upcoming surgery. Wish I didn’t need the surgery, but old age & past injuries, are catching up with me.
Steve L…. Hold tight and we’ll have the mugs available in our shop before long. You can order and take care of biz.
Alfredo in Wimberley, TX sent: 4:31 PM
Family calling – I must drop off now. Best wishes to all!
Steve Schuler (Seattle) sent: 4:31 PM
I wondered why I hadn’t heard anything… Answer: beurocrac
(can’t spell it though… :^(
Len Sierra sent: 4:36 PM
JAMA Oncol. 2019, 5, 856-863. In the first prospective trial of 68Ga-PSMA-11 PET/CT for BRPC, which included 635 patients, detection rates were 38% for PSA levels of < 1.0 ng/mL (n = 79), 84% for 1.0 to 2.0 (n=89), 86% for 2.0 to 5.0 (n=158), and 94% for >5.0. (BRPC = Bio-Recurrent PC)
Steve Schuler (Seattle) sent: 4:41 PM
a meta-observation is that most therapies that are initially only for end stage move earlier in treatment where their use there improves things. improves at least in the CSS sense, not necessarily in the OS sense
Len Sierrasent: 4:46 PM
New Terminology: • Androgen Pathway Modulator Sensitive: Tumors that continue to respond to or are controlled by androgen pathway suppression/blockade. • Androgen Pathway Modulator Resistant: Tumors that progress despite treatment targeting the androgen pathway
Steve – Seattle sent: 4:49 PM
My Calendar has the Ancan Seattle dinner scheduled for Sunday but I don’t have any details.
rick davis sent: 4:51 PM
Stand by as I said.
Steve Schuler (Seattle) sent: 4:53 PM
I’ve got to drop, but I will “stand by” to hear about Sunday. I will be at the conference Saturday, probably at Fred Hutch which I assume must be a video screen but in the FH building… That way I get a free sandwich I think :^)
RJ Smith (Seattle) sent: 4:54 PM
Same here–see you there Steve!
rick davis sent: 4:54 PM
: NCT06800313 HLD0915
George Kander
sent: 4:56 PM
Family calls – have to go. Thanks everyone and hopefully see you at dinner Friday in Portland – Chhers
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Oct. 5, 2026
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best from our Reminders and Blog Posts. Coming soon – we’re working on it!!
NEW AnCan HEART Group for all things cardio. Sign up for Reminder at https://ancan.org/contact-us/. Next meeting Oct 7 in AnCan Schmier Room. For ProsCard mailing list, please write to dr.john@ancan.org to ad to the distribution and Dr. John’s weekly heart primer.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: wot a choice this week … trials – ANDROMEDA, VIR5500 & Veozah; everyone wants scarce E2; and switch foreign drugs by 10/22!
Topics Discussed
Newbie Calgarian supported by 1.5 AnCan Calgarians; 2nd recurrence raises questions for Newbie; E2 scarcity; switch foreign online pharmacy by Oct. 22; ANDROMEDA triallist encourages others to sign up – inc. Newbies; borderline anemia delays salvage RT – but so does switching insurance; Veozah/fezolinetant trial open in Greater Boston; T and PSA rise during IHT – ANDROMEDA??; ARSI switch may be in order; does rationing Pluvicto sessions do the trick?; VIR5500 trialist experiences fatigue; Frank recovering and may be fit enough to consider a trial; GU MO orders confirmatory bone Bx before starting doublet; E2 preferred if HT resumes – or ANDROMEDA?; ; started Pluvicto – waiting on bone Bx result; ask for the PSMA SUV
Chat
Bruce Schrimpf sent: 5:12 PM
Army: Do not volunteer unless you can type. There is a story there! BDS
Danny Lankford (Minnesota) sent: 5:52 PM
I just started the e2 patch after months of wearing my GU oncologist down with evidence . 😉
john sent: 5:58 PM
At DEXA T=-1.3 you have osteopenia, and are at risk for further bone loss due to hormone therapy. Suggest Calcium 500mg twice daily (w/food if carbonate) and Vitamin D perhaps 800 IU/d. Discuss w/your PCP for a decision and doses. Weight bearing exercises. Repeat DEXA every 2y or according to your doctors. Consider E2 estradiol rather than an LHRH agonist; let’s ask Dr Paul in the room. I’m not sure at what point an endocrinologist is needed, but a bone strengthener needed because you also have a bone met.
I have tried to register for virtual prostate cancer conference at OHSU on October 17. I am provided a registration ID code, but not provided a link to access conference. What am I missing?
rick davis sent: 6:12 PM
Dr. Bill – I expect they’ll send a link closer to the conference
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Sep 21, 2026
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best from our Reminders and Blog Posts. Watch our for more details.
NEW AnCan HEART Group for all things cardio.Sign up for Reminder at https://ancan.org/contact-us/. For ProsCard mailing list, please write to dr.john@ancan.org to be added to the distribution and Dr. John’s weekly heart primer.
AnCan thanks the following sponsors for making this recording possible: Novartis, Telix and Blue Earth Diagnostics.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Go to ‘Extra Time’ to hear Newbie with PTEN, TP53 and maybe RB1
Topics Discussed
denovo N1 Newbie waits on treatment recommendations; uro assumes Newbie is denovo M1 but SUV is low – needs verification; T rises but PSA holds steady – CRPC??; offered Veozah trial – but hide the Embr watch; PSA increases from 0.16 to 1.6 – could be inflammation or RT; insist on a bone strengthener and switch docs; at least 12 m. of doublet; Reel Recovery rave review; arousal 3 months after stopping org, but Gent expects more; late Newbie faces PTEN, TP53 and possibly RB1 – treatment path???
Chat
Sergio sent: 5:41 PM
David – ty for your message. Let’s def connect. I can be reached at gonzaler84@hotmail.com. We can find time later in the week if this works for you.
Bill Lawler sent: 6:09 PM
When i was prescribed those two drugs, I was advised to stagger the start dates by ten days to two weeks.
FEZOLINETANT
Avery sent: 6:35 PM
Bill Lawler – Are you in the DMV area? If so, which hospital is your care? FYI- I just received the exact same markers and barrigel and I start my 5 and half weeks of radiation treatments on Wed at Sibley.
ok thx
Bill Lawler sent: 6:41 PM
Avery, My 28 treatments start on Oct. 1. Greater Boston area, MGB Danvers.
Avery sent: 6:41 PM
Bill – Wish you well
Bill Lawler sent: 6:49 PM
Fezolinetant principal investigator: Shehzad Basaria, Brigham & Women’s Hosp.
Bob Schwartz, USN, Venice, FL. sent: 7:08 PM
Another good mtg., have to go, see everyone next mtg.
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Two Vets both recur after a long time and cud be candidates for MDT
Topics Discussed
San Diego Veteran faces slow recurrence over 15 years – consider Matt Rettig at W.L.A. VA ; Tacoma to OSHU is well worthwhile to see Dr.E; variant disease produces plenty of PSA but doesn’t respond – Ac225 trial @ MSKCC a possibility; NW Montana G9 Vet recurs after Brachy + ADT @ Huntsman in 2019 – PSA now 18.5; older Gent has bone density issues.
Chat
Dan M, Tacoma WA sent: 3:26 PM
The liquid biopsy phlebotomists will even come to your house.
Bill Lawler sent: 3:37 PM
I’ve been on Darolutamide & Orgovyk ADT treatment for two months. at six weeks my PSA dropped from 14.4 to1.18.
Danny Lankford (Minnesota) sent: 3:41 PM
Ditto here. I started on Darolutamide and Orgovyx and my PSA went from 13-ish down to 0.04 in 3 months.
AnCan–John A sent: 3:41 PM
in one or two years > new theranostics with new cancer cell markers
Alfredo in Wimberley, TX sent: 4:18 PM
Sorry, I must leave early tonight. Best regards to everyone.
Ben Nathanson sent: 4:23 PM
I’m still listening
AnCan–John A sent: 4:30 PM
Dr Theresa Werner is now deputy director at Huntsman
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Sep 7, 2026
Are you in DelMarVa?? Reserve Wednesday night, Sep 16 for an AnCan get-together. We’ll meet for a ‘dutch’ dinner in the Chevy Chase area – location TBD. If you have not received an email invitation and would like to attend, please drop a note to boykin@ancan.org. Partners/spouses welcome!
And if you’re in Los Angeles or going to PCRI Sep 18-20, please reach out to Bill Franklin as we may hold an AnCan meetup.
Substack is coming to AnCan… or maybe AnCan is coming to Substack. We’ll be posting the best of all our Reminders. Watch our for more details.
AnCan thanks the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Severe radiation cystitis interferes with treatment plans
Topics Discussed
Was this Newbie really a 5+4 at Dx in 2010?; RT done – now to HT and what next?; crippling RT cystitis changes PrCa treatment plans; could Pluvicto be an option for mHSPC Gent; extensive initial RT preferred; why can’t RO prescribe HT?; move forward with salvage RT and adjust LHRH; muscle cramps; move to CoH, Duarte makes difference; does Pluvicto need prior hydration infusion?; surprise bone Bx – somatic sequencing may take time; RT finished – what to expect during doublet HT?; is screen for blood clot or variant PrCa?
Chat
Jeff Marchi – San Francisco sent: 5:17 PM
877-582-7011 tech support
AnCan–John A sent: 5:18 PM
thanks Jeff and Jim. try that Gary
Gary P sent: 5:36 PM
The second one sent by you. Just got off phone. Thanks very much.
Damon I thought you said HDR rather than low dose brachy, but I might have misheard?
Gary Martin sent: 7:39 PM
I’ve heard the FDG PET scans and the biomarkers including LDH, Chromogranin A, NSE, and CEA are often tracked where PSA-discordant progression may be suspected.
