New Prostate Cancer Guidelines and ASPI Pathway

New Prostate Cancer Guidelines and ASPI Pathway

by | May 18, 2026 | Active Surveillance PCa, High Risk/Recurrent/Advanced Prostate Cancer, Low/Intermediate Prostate Cancer, Prostate Cancer, Recent News

A relatively new year, new guidelines, and new tools for prostate cancer screening and monitoring.

In recent months, the AUA updated its 2023 guidelines specifically for early detection of prostate cancer (https://www.auanet.org/guidelines-and-quality/guidelines/early-detection-of-prostate-cancer-guideline). Along with those guidelines, two other organizations have updated or developed additional tools that are beneficial to all men, regardless of where they are on the prostate cancer journey (or even those not yet on a journey).

The National Comprehensive Cancer Center Network (NCCN) posted its 2026 “Guidelines for Patients” pamphlet for early-stage prostate cancer (https://www.nccn.org/patients/guidelines/content/PDF/prostate-early-patient.pdf).  Additionally, our friends at ASPI (https://aspatients.org/) have produced a pamphlet primarily focused on active surveillance: The Pathway: Your Guide to Active Surveillance, also reviewed by Howard Wolinsky ( https://howardwolinsky.substack.com/p/review-of-aspis-the-pathway-navigating )

Consider them collectively as an introduction to screening (NCCN), an AS-focused source (ASPI), and a comprehensive guide for early-stage prostate cancer.

I would not consider any of them as a standalone product for all the information a man might need. The NCCN guidelines are focused on screening and are relatively basic. ASPI’s product is focused on AS, but some may find the scope and scale of information a bit overwhelming without someone to advise and assist them. The appendix at the end of the pamphlet would be exceedingly useful for anyone beginning their prostate cancer journey. Finally, the AUA guidelines are broader and developed more for urologists.

–Dan Gifford (dan@ancan.org)

Prostate Cancer and GU Pathology 2nd Opinions

Prostate Cancer and GU Pathology 2nd Opinions

by | May 16, 2026 | Active Surveillance PCa, High Risk/Recurrent/Advanced, High Risk/Recurrent/Advanced Prostate Cancer, Low/Intermediate Prostate Cancer, mCRPC, mHSPC, Prostate Cancer, Uncategorized

Prostate Cancer and GU Pathology 2nd Opinions

AnCan frequently recommends second opinions on prostate cancer and genitourinary (GU) pathology slides – whether it be from biopsy, surgery or another protocol. Our recommended providers are:

Jonathan Epstein, MD, Advanced Uro Pathology   T: 516-760-2037     jepstein@imppllc.com    https://advanceduropathology.com   

Ming Zhou, MD, PHD, Mount Sinai (NYC) Health,   T: 516-760-2037  Ming.zhou@mountsinai.org

Jesse McKenney  MD,  Cleveland Clinic   https://clevelandcliniclabs.com/healthcare-provider-resources/pathology/

Johns Hopkins Pathology  https://pathology.jhu.edu/patient-care/second-opinions

Video Resources

(Thanks to Eric Milsen in compiling this post)

Low/Intermediate PCa Video Chat, 5/11/2026

Low/Intermediate PCa Video Chat, 5/11/2026

by | May 12, 2026 | Cancer Caregivers, Cancer Resources, Low/Intermediate Prostate Cancer, Recorded Groups

Low/Intermediate PCa Video Chat, 5/11/2026

Low/Intermediate PCa Video Chat, 5/11/2026

AnCan is grateful to the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics, and Foundation Medicine.

WELCOME all to our newly recorded Low/Intermediate Prostate Cancer Group. To receive notice when new recordings are posted, either follow us on this YouTube Channel or sign up to our Blog via https://ancan.org/contact-us/ – check New Blog box.

Join our other free and drop in groups:
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime!

Editor’s Pick: New prostate cancer (PCa) diagnosis with potential Lynch Syndrome in the family. (bj)

Topics Discussed
New diagnosis with potential Lynch Syndrome in the family; exploring genetic testing as well as somatic vs germline testing; be careful about interpreting test results as a guarantee; two types of prostate cancer bioposies—transperineal carries less infection risk; primer on different radiation treatments for prostate cancer; focal treatment carries high recurrence risk with Gleason Score 4+3 or higher; cyber knife, nano knife, heat therapy are forms of focal treatment; things to expect three weeks after a radical prostatectomy; dealing with anxiety following a radical prostatectomy or PSA changes following treatment; Artera AI as a predictor of biochemical recurrence.

Chat

Stuart sent a chat · 7:50 PM
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881

Stuart sent a chat · 7:51 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/  Tel:516-760-2037    jepstein@imppllc.com

AnCan – Boykin sent a chat · 8:12 PM
Last Low/Intermediate Video Chat on YouTube (same as above)  https://www.youtube.com/watch?v=-jMy0byKzdE

AnCan – rick sent a chat · 8:24 PM
Also Jesse McKenney at Cleveland Clinic   mckennj@ccf.org   Expert on cribriform

 AnCan Bill sent a chat · 8:53 PM
stuart@ancan.org & bfranklin@ancan.org

medium.com/@mperloe sent a chat · 8:54 PM
Is brachy indicated after sepsis from the biopsy? I’d sure be leery of that.

Steve in Malaysia sent a chat · 9:05 PM
The canadian health system is per province vs national.

Steve in Malaysia sent a chat · 9:05 PM
Sunnybrook in Toronto is the most advanced center and has all modalities including MR Linac

Steve in Malaysia sent a chat · 9:07 PM
i believe there is also MR Linac in Calgary.

AnCan – rick sent a chat · 9:08 PM
We’re aware, Steve. BC is not too bad. Also v. familiar with Sunnybrook/Klotz

Steve in Malaysia sent a chat · 9:08 PM
👍

Bob in Georgia sent a chat · 9:17 PM
I leave next tuesday, preop on Wed, spacor on Thurs

AnCan – Boykin sent a chat · 9:21 PM
boykin@ancan.org

 AnCan Bill sent a chat · 9:22 PM
Ask for a referral to Pelvic Floor Physical Therapy.

Bob in Georgia sent a chat · 9:27 PM
Going to Sloan Kettering with Dr Nagar

Mark WV sent a chat · 9:28 PM
nite

AnCan – Boykin sent a chat · 9:29 PM
Good nite Mark!

 AnCan Bill sent a chat · 9:33 PM
May 21st at 8 p.m. Eastern is the next MSF.

AnCan – rick sent a chat · 9:33 PM
Next MSF meeting … in this room same time on Thu May 21

Larry S – ADT by estradiol sent a chat · 9:49 PM
Re: When to stop PSA testing.  I have not read this yet (it just came into my inbox this morning), but the synopsis looks hopeful for more men getting screened later in life and having those tests INTERPRETED MORE INTELLIGENTLY so as to avoid alarm and unnecessary procedures.  https://www.news-medical.net/news/20260428/NCCN-publishes-new-patient-guide-for-prostate-cancer-screening.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=prostate_cancer_newsletter_10_may_2026

AnCan – rick sent a chat · 9:49 PM
from Joel…”Got it. Thank you Rick”

Bob in Georgia sent a chat · 9:53 PM
Nite

AnCan – Boykin sent a chat · 9:53 PM
Good night Bob!

AnCan – Boykin sent a chat · 9:59 PM
Artera AI https://artera.ai/

Fritz sent a chat · 10:05 PM
Thanks so much -I’ll report back next meeting. Safe journey everyone

Jim E., Ft. Worth TX sent a chat · 10:11 PM
Have to go for now. Thanks so much!

Low/Intermediate PCa Video Chat, 5/11/2026

Low/Intermediate PCa Video Chat, 4/27/2026

by | May 10, 2026 | Cancer Caregivers, Cancer Resources, Low/Intermediate Prostate Cancer, Recorded Groups

Low/Intermediate PCa Video Chat, 4/27/2026

Low/Intermediate PCa Video Chat, 4/27/2026

AnCan is grateful to the following sponsors for making this recording possible: Novartis, Blue Earth Diagnostics, and Foundation Medicine.

WELCOME all to our newly recorded Low/Intermediate Prostate Cancer Group. To receive notice when new recordings are posted, either follow us on this YouTube Channel or sign up to our Blog via https://ancan.org/contact-us/ – check New Blog box.

Join our other free and drop in groups:
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime!

Editor’s Pick: Treatment at Center of Excellence (COE) preferred over Community Care. (bj)

Topics Discussed
Using the Memorial Sloan Kettering Cancer Center (MSKCC) Nomogram to predict the success rate of surgery versus recurrence risk; clinical significance of cribriform patterns in pathology reports; Androgen Deprivation Theory (ADT) & Cardiac Health means understanding the diffference between short- and long-term risks as well as the importance of cardio-oncology monitoring; getting second opinions from on pathology reports are important to confirm Gleason score and identify other potential concerns; treatment at a Center of Execellence (COE) preferred over Community Care because COE offer integrated, multi-disciplianary and access to advanced technologies.

Chat

AnCan – Boykin sent a chat · 8:01 PM
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881

AnCan – Boykin sent a chat · 8:02 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/  Tel:516-760-2037    jepstein@imppllc.com

Steve Ft Worth sent a chat · 8:15 PM
STeven Warwick

AnCan – Rick sent a chat · 8:19 PM
GoTo  877 582 7011    for tech assistance

AnCan Bill sent a chat · 8:31 PM
http://nomograms.mskcc.org/Prostate/index.aspx

AnCan – Boykin sent a chat · 8:38 PM
Have him run the MSKCC nomogram http://nomograms.mskcc.org/Prostate/index.aspx

David in Portland, OR sent a chat · 8:39 PM
Active Monitoring, Surgery, and Radiotherapy for Cribriform-Positive and Cribriform-Negative Prostate Cancer: A Secondary Analysis of the PROTECT Randomized Clinical Trial (Sushentsev, Nikita): https://jamanetwork.com/journals/jamaoncology/article-abstract/2840006?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamaoncol.2025.4125

Jp sent a chat · 8:46 PM
Can I ask a question on here by chat ?

Jp sent a chat · 8:47 PM
Ok

AnCan Bill sent a chat · 8:49 PM
JP – you can put something in the chat. If you wait until the end, we’ll get to you in the virtual room.

Jp sent a chat · 8:50 PM
Thank you

My question is about the real side effects of chemo

My doctor wants me to start in September

Jp sent a chat · 8:52 PM
Got it thank you

Jp sent a chat · 8:52 PM
New

Jp sent a chat · 8:53 PM
🙏

AnCan – Rick sent a chat · 9:07 PM
Focal therapy article on our bloghttps://ancan.org/prostate-cancer-focal-therapy-as-primary-treatment/

AnCan – Rick sent a chat · 9:08 PM
https://ancan.org/prostate-cancer-focal-therapy-as-primary-treatment/

David in Portland, OR sent a chat · 9:55 PM
A Phase III Randomize Controlled Trial of Sterotactic Body Radiotherapy in Localized Prostate Cancer: Pace-B Trial (van As, Nicholas): https://pmc.ncbi.nlm.nih.gov/articles/PMC7616714/?utm_source=chatgpt.com

AnCan Bill sent a chat · 9:58 PM
https://ancan.org/events/month/

Predicting Radiation Side Effects – PROSTOX Webinar with interesting updates!

Predicting Radiation Side Effects – PROSTOX Webinar with interesting updates!

by | Apr 29, 2026 | High Risk/Recurrent/Advanced Prostate Cancer, Low/Intermediate Prostate Cancer, Prostate Cancer, Webinars

Predicting Radiation Side Effects – PROSTOX Webinar with interesting updates!

 

 

Last year, we presented a webinar on predicting Prostate Cancer Radiation Treatment side effects with PROSTOX before treatment begins. By analyzing your unique genetics, you can make smarter, more informed decisions to avoid side effects and safeguard your quality of life for years to come.

PROSTOX Standard (previously PROSTOX CFRT+) predicts late grade ≥2 toxicity from conventionally fractionated (CFRT) or moderately hypofractionated (MHFRT) radiation therapy for patients with localized prostate cancer. Together with PROSTOX Ultra, which is already available for patients considering stereotactic body radiation therapy (SBRT), the PROSTOX portfolio now provides risk assessment across a broader range of external beam radiation therapy (EBRT) types. We’ll discuss the updates and other patient concerns, such as insurance coverage and questions to bring to your doctors.

To find a copy of the slides, click here.

Low/Intermediate PCa Video Chat, 5/11/2026

Low/Intermediate PCa Video Chat, 4/13/2026

by | Apr 15, 2026 | Cancer Caregivers, Cancer Resources, Low/Intermediate Prostate Cancer, Recorded Groups

Low/Intermediate PCa Video Chat, 4/13/2026

Low/Intermediate PCa Video Chat, 4/13/2026

AnCan is grateful to the following sponsors for making this recording possible: Novartis, Telix, Blue Earth Diagnostics, and Foundation Medicine.

WELCOME all to our newly recorded Low/Intermediate Prostate Cancer Group. To receive notice when new recordings are posted, either follow us on this YouTube Channel or sign up to our Blog via https://ancan.org/contact-us/ – check New Blog box.

Join our other free and drop in groups:
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime!

Editor’s Pick: Questions about the efficacy of clinical trials for focal therapy treatment of prostate cancer. (bj)

Topics Discussed
New diagnosis and seeking second opinions on treatment options; potential candidate for active surveillance; importance of getting second opinion on biopsy results; Stereotactic Body Radiation Therapy (SBRT) scheduled—5 sessions over a 10-day period; concerns about traveling to a center of excellence for treatment and then receiving follow-up care locally; questions about the efficacy of clinical trails in general and specifically focal therapy for prostate cancer; difficulties in getting insurance companies to approve medical treatments; differences between germline and somatic (Decipher) genetic testing; avoid the “Google Trap”—don’t make your treatment decisions based on internet searches.

Chat

AnCan – Stuart sent a chat · 7:54 PM
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881

AnCan – Stuart sent a chat · 7:55 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/  Tel:516-760-2037    jepstein@imppllc.com

AnCan – Rick sent a chat · 8:19 PM
The Emperor… Great scans and a PSA of 0.2 with a healthy prostate 😏

David in Portland, OR sent a chat · 8:52 PM
“Delayed Definitive Management of Localized Prostate Cancer: What Do We Know?” Co-authors include Peter Carroll and Mack Roach, https://doi.org/10.1038/s41391-024-00876-2

AnCan – Rick sent a chat · 8:59 PM
PROMISE https://www.prostatecancerpromise.org/?utm_campaign=ANCAN&utm_medium=link&utm_source=Webinar

AnCan – Boykin sent a chat · 9:00 PM
AnCan Foundation YouTube Channel
https://www.youtube.com/@ancanfoundation

medium.com/@mperloe sent a chat · 9:02 PM
Thanks guys. Hope all is well.

AnCan – Boykin sent a chat · 9:03 PM
All is well. Good to see you.

Steve in Malaysia sent a chat · 9:08 PM
I have a few short questions.

AnCan – Rick sent a chat · 9:09 PM
Have to wait until the back end, Steve

Steve in Malaysia sent a chat · 9:09 PM
ok 👍

AnCan – Boykin sent a chat · 9:15 PM
AnCan Prostox https://ancan.org/?s=prostox

Bill (VA) sent a chat · 9:26 PM
https://clinicaltrials.gov/study/NCT06807359

David in Portland, ORsent a chat · 9:46 PM
“Can You Take Cash From Medicare Patients?” https://elitenp.com/medicare-and-cash-practices/?utm_source=chatgpt.com

AnCan – Rick sent a chat · 9:49 PM
Thank you David….