Hi-Risk/Recurrent/Advanced PCa Video Chat, June 13, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant & Telix
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Editor’s pick: Prostatectomy after 70. Also: Pluvicto wiped out 99% of his cancer — time for a jig! (bn)
Topics Discussed
Metformin’s faded glory in PCa treatment; grateful for heads-up on Xgeva with radium-223; statins and PCa — still anybody’s guess; darolutamide monotherapy might cut fatigue; curious about new hot-flash drug for women; experience with Onco360 pharmacy; when will white blood cells rebound from radiation; bike seats and PCa; seeing metastasis in lymph nodes that radiation skipped; dry mouth and depression overshadow wild Pluvicto success; too old for prostatectomy?; Keytruda and more Keytruda.
Chat Log
Steve in MI · 6:09 PM
Suttons Bay is nice; my wife has a few properties she manages up there. We get to Interlochen at least 2 or 3 times during the summer for concerts. Styx is the next one.
Steve in MI · 6:13 PM
There is a few up around here in the summer: Charlevoix, Fish Town, Elk Rapids. Ours is in August I think.
Julian – Houston · 6:18 PM
stopped taking because it made my bones ache!
Gary P · 6:20 PM
While not actually diabetic, I was put on Metformin after my blood sugar levels went up significantly on Abiraterone.
Julian – Houston · 6:24 PM
Same here, Gary. Took for awhile and my A1C came down.
AnCan – rick · 6:27 PM
Steve in MI …. check out this link https://pubmed.ncbi.nlm.nih.gov/?term=prostate+cancer%2C+statins
David Muslin · 6:36 PM
New hot flash drug just approved Fezolinetant aka Veozah
AnCan – rick · 6:38 PM
It was FDA approved on May 16… this is the one I read about
AnCan – rick · 6:39 PM
https://www.fda.gov/news-events/press-announcements/fda-approves-novel-drug-treat-moderate-severe-hot-flashes-caused-menopause#:~:text=Today%2C%20the%20U.S.%20Food%20and,hot%20flashes%2C%20caused%20by%20menopause.
Julian – Houston · 7:09 PM
Totally agree with exercising!!! It is necessary!
? · 7:12 PM
Agree. Hot flashes less severe or non-existent on days I walk 5 miles, so I go every day. Big motivator.
? · 7:22 PM
Jaynewman@cox.net
Dennis Correia · 7:26 PM
Try Biotene mouth rinse for dry mouth.
AnCan – rick · 7:31 PM
Pluvicto FDA approval https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pluvicto-metastatic-castration-resistant-prostate-cancer
AnCan – rick · 7:33 PM
“Patients received Pluvicto 7.4 GBq (200 mCi) every 6 weeks for up to a total of 6 doses plus BSoC or BSoC alone.”
BSoC = best standard of care
Tom Maloney · 7:34 PM
The recommended Pluvicto dose is 7.4 GBq (200 mCi) intravenously every 6 weeks for up to 6 doses, or until disease progression or unacceptable toxicity.
Tom Maloney · 7:34 PM
up to 6 doses, not requiring 6 doses.
AnCan – rick · 7:34 PM
The trials all gave 6 doses
Len Sierra · 7:36 PM
Tom, the dry mouth usually resolves by itself soon after your treatment is complete.
AnCan – rick · 7:38 PM
We do not know anyone who did less than 5 doses by choice. Doesn’t mean there aren’t any. However your doc is recommending you finish up.
AnCan – rick · 7:39 PM
We’ve seen less than 6 doses but only where blood counts or other markers have been compromised.
AnCan – rick · 7:45 PM
Xgeva = denosumab
Steve in MI · 7:52 PM
Keep coming back Spencer.
? · 7:52 PM
Thank you to everyone for excellent advise.
Joe (Dubois WY) · 7:59 PM
keytruda
Julian – Houston · 7:59 PM
Keytruda
Julian – Houston · 8:00 PM
Thanks guys. Another great session.
Joe (Dubois WY) · 8:04 PM
https://www.ouhealth.com/find-a-doctor/?Specialty=287086&Distance=5 Urologic Oncologists at OU in OKC
Joe (Dubois WY) · 8:05 PM
https://www.ouhealth.com/find-a-doctor/michael-s-cookson-md-mmhc/ this guy did a fleewship at MSK
Joe (Dubois WY) · 8:05 PM
fellowship
AnCan – rick · 8:05 PM
A urologic oncologist is a surgeon Joe. Not a med onc.
Joe (Dubois WY) · 8:05 PM
oh bummer
AnCan – rick · 8:06 PM
He needs a genitourinary medical oncologist
Joe (Dubois WY) · 8:06 PM
sure as hell standing in front a a Davinci