Low/Intermediate PCa Video Chat, January 12, 2026

Low/Intermediate PCa Video Chat, January 12, 2026

AnCan is grateful to the following sponsors for making this recording possible: Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics, and Foundation Medicine.

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Editor’s Pick: Using DECIPHER genomic testing to assess cancer agressiveness. (bj)

Topics Discussed
Cancer discovery following an aquablation procedure for an enlarged prostate; post-procedure PSA and MRI testing to monitor remaining cancer; comparing transrectal and transperineal biopsy safety and access; importance of consulting genitourinary oncologists at major centers; using specialists like Dr. Epstein for pathology second opinions; weighing active surveillance against the risk of cancer progression; discussion of MR LINAC, proton, and photon radiation technologies; using PSMA PET scans to detect potential lymph node involvement; selecting high-volume urban medical centers over smaller clinics; using DECIPHER genomic testing to assess cancer agressiveness.

Chat

Stuart sent a chat · 8:01 PM
Dr. Ming Zhou – Mt Sinai Health System  Email: Ming.zhou@mountsinai.org      Telephone: (212)241-8881

Stuart sent a chat · 8:02 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/  Tel:516-760-2037    jepstein@imppllc.com

Steve in Malaysia sent a chat · 8:39 PM
What is an AI MRI?

Steve in Malaysia sent a chat · 8:42 PM
ok 👍

AnCan – rick sent a chat · 8:48 PM
Proton vs Photon  https://ascopubs.org/doi/abs/10.1200/JCO.23.01604?md5=efb3c3159aa147415d4f2ded3334efa3&cid=DM16707&bid=358786211

Gil Solomon sent a chat · 8:52 PM
Have to sign off for dinner.

Steve in Malaysia sent a chat · 8:57 PM
I need to finish packing for trip from Penang to California shortly so would appreciate some quick questions.

AnCan – rick sent a chat · 9:07 PM
Check our AnCan video with Dr. Scholz  on Prostate Snatchers. https://ancan.org/the-prostate-snatchers-still-lurking/

Steve sent a chat · 9:14 PM
Carter

AnCan – rick sent a chat · 9:25 PM
Steve – CHEK2 may in fact make you more sensitive to RT. Check with Dr. Kivel

Steve sent a chat · 9:28 PM
Thanks Rick!

David in Portland, OR sent a chat · 9:39 PM
“Most mutations in DNA repair genes such as BRCA1/2, PALB2, CHEK2, and RAD50/51 mutations do not increase radiation-induced cancers or radiation toxicity. BRCA1/2, PALB2, CHEK2, and RAD50/51 mutations should not affect radiation therapy decisions.” Source: https://www.redjournal.org/article/S0360-3016(19)33530-8/fulltext I also communicated with Joanne Wiedhaas last year directly about this topic, and she confirmed the above quote from the International Journal of Radiation Oncology.

Govinda – India sent a chat · 9:41 PM
Daily dosage of  Viagra was 5 mg daily. Of course this varies from person to person.

Steve in Malaysia sent a chat · 9:42 PM
I’m going to sign off… thanks guys

David in Portland, OR sent a chat · 9:42 PM
5 milligrams/day of tadalafil/Cialis gives me significant heartburn. Anybody else have this problem? Any fixes other than stopping the Cialis?

AnCan – rick sent a chat · 9:51 PM
Interesting David….    the general opinion is that HRR mutations make you more sensitive to RT toxicity. I think there’s a fair amount of literature.

Stuart sent a chat · 9:56 PM
Dr James Hu – Weill Cornell

Stuart sent a chat · 9:56 PM
Dr Nagar – MSKCC

Stuart sent a chat · 9:57 PM
or Michael J. Zelefsky, MD – NYU Langone

Steve sent a chat · 10:17 PM
Thanks David!