Hi-Risk/Recurrent/Advanced PCa Video Chat, Aug 21, 2023
AnCan is grateful to the following sponsors for making this recording possible:
Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s pick: Giving medical advice vs providing information (as AnCan does)… it’s a delicate balance that one Gent doesn’t want to hear. (rd)
Topics Discussed
docetaxel + Pluvicto trial; PALB2 actionable; spot RT to L4; need a GU med onc NOT uro at SF-VA; FDG scan largely confirms PSMA; coming off prednisone; ACTH test; KP Maui gent needs Dr. Harzstark for IHT discussion; soursop/graviola may help but talk to HCP; post Pluvicto, check concordance; using metformin; blood counts; healthy prostate tissue may muddy the waters; 7 years on abi carries risk of morphing – but Gent doesn’t want to her that; time for IHT??; PSA testing frequency Chat Log
Chat Log
Jim Marshall, Alexandria, VA sent · 5:24 PM
ATM was another mutation which got thrown into the mix.
Joe Gallo sent · 5:31 PM
Webinar: PARP-Inhibitors and Prostate Cancer – Gotta Have a Mutation??? by Alexa Jett | Jul 1, 2023 | Recent News, Webinars https://youtu.be/DErm2tkTiws
Hi-Risk/Recurrent/Advanced PCa Video Chat, Aug 7, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
NOTE: August schedule change for Tuesday meetings only – next meeting Aug 15
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
Editor’s pick: Mayo offers great docs… provided you select them. Otherwise ‘caveat emptor!’! (rd)
Topics Discussed
Recurrent VA patient lucks out at VA-SF; singlet vs doublet therapy; Dr. E gears up for The General; when to go back on HT .. and what HT exactly; PSA spikes after 2 pembros… that can happen!; Mayo fails to get it right around Pluvicto – or maybe it’s just the wrong doc; what’s the difference between LHRH/ADT drugs?; what type of RT is needed?; prostate area lights up – lungs do not??; stay away from the local uro and get back to the GU med onc
Hi-Risk/Recurrent/Advanced PCa Video Chat, July 17, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
NOTE: August Schedule Change for Tuesday meetings only – Tuesday, Aug 1 and 15
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Worth waiting until the end to hear our sonorous tones on the Eastern Front relate liver marker issues during Pluvicto… but maybe down to gabapentin?? (rd)
TopicsDiscussed
New sponsor Blue Earth and Posluma; younger man (55) reports successful treatment; denovo Mx gent needs GU med onc; drug financial subsidies help- one of our gents; hypertension and abiraterone; neurological symptoms; lodging suggestions during treatment; cancer returns to prostate bed; 2nd series of Pluvicto treatments; what to do when PSA makes tiny move off insignificant; ALT & AST swing during Pluvicto – could it be an unrelated drug?; gabapentin issues
Chat Log
AnCan – rick sent · 5:34 PM Dr. Andrea Harzstark
AnCan – rick sent · 5:38 PM rd@ancan.org
Jim Marshall, Alexandria, VA sent · 5:59 PM Zytiga is also called Abiraterone It is generic.
Jim Marshall, Alexandria, VA sent · 6:03 PM Genitourinary Medical Oncologist
Julian – Houston sent · 6:30 PM Dr. E is awesome!!!
AnCan – rick sent · 6:39 PM Who in Houston would talk to me about where to stay when going to MD Anderson. Can you say?
Matt Krieger sent · 6:41 PM What is pluvecto (spelling?)?
Peter Kafka – Maui sent · 6:41 PM Most centers have a sheet with places to stay that work with the hospital. Call your doc’s receptionist
AnCan – rick sent · 6:42 PM Pluvicto
Joe Gallo – Bucks Cty PA sent · 6:45 PM One of our AS moderators Hugh Idstein is a Houston resident if you want any help beyond the hospital list.
Richard Tolbert sent · 6:47 PM I live in the Houston area and can provide some hotel options near M.D. Anderson. (contact rd@ancan.org for Richard’s email)
AnCan – rick sent · 6:48 PM Another question to me from John Babb: As a disabled veteran which base or post would the best to try for housing while I am at MD Anderson?
Matt Krieger sent · 6:49 PM I nap every day at 55 if I can find a way!!
Don Needham – Bend, Or sent · 6:50 PM I nap every day after my walk and weights.
Julian – Houston sent · 6:50 PM Naps are good – I try to take one every mid-afternoon.
Matt Krieger sent · 6:58 PM It seems like everyone here is having PSA tests that have a sensitivity down to like .01, whereas the Kaiser tests I get just say ‘less than .06’ if it’s below that level. Should I be pushing for a more sensitive test, does that have value?
Peter Kafka – Maui sent · 7:00 PM You can try asking Kaiser about ultra sensitive PSA testing. But usually they only use it for guys who have had a prostatectomy as primary rather than radiation,
AnCan – rick sent · 7:01 PM Matt – My suggestion would be not to worry. You still have a prostate. I agree with Peter – not needed if you have a prostate.
Matt Krieger sent · 7:01 PM Got it, makes sense and thanks much —
Jim Marshall, Alexandria, VA sent · 7:02 PM Am using Kaiser and I get the Ultra-Sensitive every month for last year Mid Atlantic Kaiser
Frank Fabish Columbus OH sent · 7:06 PM Got to guys. Thanks guys. Stay strong.
Richard Tolbert sent · 7:07 PM Thanks everyone. Have a great week!
Hi-Risk/Recurrent/Advanced PCa Video Chat, July 11, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
NOTE: August Schedule Change for Tuesday meeting only – Tuesday, Aug 1 and 15
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Abiraterone can have significant cardio comorbidities (rd)
Topics discussed
Immediate recurrence following RP; older Gent seeks GU med onc after 12 years; PSA fluctuates during Pluvicto; no more Pluvicto problems – maybe thanks to AnCan!; GU med onc in Toronto – but is it needed?; abi +meddling with dosage may have lead to heart issues; older Gent continue Pluvicto; HT therapy does what it should – to the concern of this physician patient; doc raises darolutamide monotherapy; upcoming webinar and August calendar change
Chat Log
Neil Brandom sent · 3:23 PM Note to self : GU Medical oncologist Mathew Rettic UCLA Rana McKay UCSD
Len Sierra sent · 4:59 PM Jack et al., This is why you want to take darolutamide even with a low T level: Nubeqa (darolutamide) is an androgen receptor inhibitor. Darolutamide competitively inhibits androgen binding, AR nuclear translocation, and AR-mediated transcription
Alan Babcock sent · 5:02 PM That makes my wife happy. bye
Hi-Risk/Recurrent/Advanced PCa Video Chat, June 19, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
WEBINAR next week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at https://tinyurl.com/ancanparpwebinar
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Switching to darolutamide; is ARV7 still relevant?; cabazitaxel (Jevtana) vs docetaxel (Taxotere); mega fatigue may warrant a drug holiday; starting Pluvicto on top of chemo; Ambrx ARX517 trial; troublesome hot flashes are a flashpoint; picking the right GU med onc; starting immunotherapy while tapering on steroids; pectin supplements
Chat Log
Len Sierra sent · 5:28 PM Darolutamide inhibited the transcriptional activity of AR mutants identified in the plasma of CRPC patients progressing on traditional therapies. In particular, darolutamide significantly inhibited the transcriptional activity of the F877L, H875Y/T878A, F877L/T878A, and the previously unreported T878G AR mutants, that transform enzalutamide into a partial agonist.
John A sent · 5:33 PM Liu et al. Selective degradation of AR-V7 to overcome castration resistance of prostate cancer. Cell Death Dis. 2021
AnCan – rick sent · 5:38 PM Oliver Sartor now at Mayo
AnCan – rick sent · 5:49 PM Depo-Provera
George Southiere sent · 5:56 PM ACTH(adrenocorticotrphic) stimulation test = patient given ACTH and adrenal gland function is assessed- usually done by Endocrinologist
John A sent · 5:57 PM thanks
George Pat Martin sent · 6:00 PM I’m worn out. Gonna log off . be back next week
AnCan – rick sent · 6:04 PM Venlafaxine
Len Sierra sent · 6:05 PM https://embrlabs.com/products/embr-wave-2
AnCan – rick sent · 6:07 PM Embr watch.. d/c
Ancan50 sent · 6:07 PM Depo provera
George Southiere sent · 6:08 PM Gabapentin has helped me due to my severe neuropathy and has helped the hot flashes for me
sent · 6:09 PM I take 600mg gabapentin 3 times a day now. It never helped with my hot flashes.
Len Sierra sent · 6:37 PM modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:39 PM 1. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:40 PM https://pubmed.ncbi.nlm.nih.gov/14663471/
Salvador sent · 6:43 PM Thank You for your feedback.
Chip & Jane sent · 6:48 PM G’nite All.. thanks for the fine discussion.
George Rovder, Arlington VA sent · 6:52 PM Thank you all. Good Night.
Salvador sent · 6:53 PM Thank You everyone, I learned a lot tonight
Terrill SF sent · 6:53 PM Thank you all. Good Night.
