Hi-Risk/Recurrent/Advanced PCa Video Chat, July 11, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
NOTE: August Schedule Change for Tuesday meeting only – Tuesday, Aug 1 and 15
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Abiraterone can have significant cardio comorbidities (rd)
Topics discussed
Immediate recurrence following RP; older Gent seeks GU med onc after 12 years; PSA fluctuates during Pluvicto; no more Pluvicto problems – maybe thanks to AnCan!; GU med onc in Toronto – but is it needed?; abi +meddling with dosage may have lead to heart issues; older Gent continue Pluvicto; HT therapy does what it should – to the concern of this physician patient; doc raises darolutamide monotherapy; upcoming webinar and August calendar change
Chat Log
Neil Brandom sent · 3:23 PM Note to self : GU Medical oncologist Mathew Rettic UCLA Rana McKay UCSD
Len Sierra sent · 4:59 PM Jack et al., This is why you want to take darolutamide even with a low T level: Nubeqa (darolutamide) is an androgen receptor inhibitor. Darolutamide competitively inhibits androgen binding, AR nuclear translocation, and AR-mediated transcription
Alan Babcock sent · 5:02 PM That makes my wife happy. bye
Hi-Risk/Recurrent/Advanced PCa Video Chat, June 27, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
WEBINAR this week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at https://tinyurl.com/ancanparpwebinar
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s pick:Where next when standard treatments are behind you? (bn)
Topics discussed
Chance a risky trial hundreds of miles away?; think ahead before firing the last bullet; mixed reviews of Cancer Commons; “too old for a PSA test” and now metastatic; what’s “Pluvicto” in Canadian?; one man, two dueling prostate cancers; making it through Pluvicto; check for PSMA avidity before a pricey treatment; will Pluvicto last?; facing chemo after six lucky years on ADT; after success with triplet therapy, time for drug holiday?; new man starting Keytruda; bad cancer + low PSA?; shrinking the unshrinkable prostate; turned away at OHSU and seeking something comparable; magnesium for neutropenia; BAT is no home run; what counts as exercise?
Chat Log
Mark Finn · 7:06 PM
Rick – finishing up packing for camping trip. Will have to depart soon.
David Muslin · 7:07 PM
Have fun Mark Finn
Ben Nathanson · 7:19 PM
Pluvicto – generic “lutetium Lu 177 vipivotide tetraxetan” – formerly “Lu-177 PSMA-617”
Frank Fabish Columbus OH · 7:32 PM
Got to go guys. Thanks again for good info. see you next Monday.
David Muslin · 7:48 PM
Got to roll men. See y’all next week.
AnCan – rick · 7:49 PM
646-749-3129 222 583 973
Steve Schuler · 7:49 PM
I think my laptop needs a reboot
Steve Schuler · 7:50 PM
My question was really simple actually: any suggestions in the northwest for good med oncologists for second opinions?
Bob G · 7:50 PM
Gotta go. Fatigue kicking in.
Steve Schuler · 7:51 PM
Yes, I’ve tried both the ear buds and now the laptop microphone, and neither is working for the microphone
Steve Schuler · 7:53 PM
Washington, Oregon, or I am also looking now at CA (San Francisco). I am willing to travel some. I am in Seattle
AnCan – rick · 7:53 PM
I’ll ask ….
Julian – Houston · 7:54 PM
Go to go – see you next week!
Hi-Risk/Recurrent/Advanced PCa Video Chat, June 19, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
WEBINAR next week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at https://tinyurl.com/ancanparpwebinar
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Switching to darolutamide; is ARV7 still relevant?; cabazitaxel (Jevtana) vs docetaxel (Taxotere); mega fatigue may warrant a drug holiday; starting Pluvicto on top of chemo; Ambrx ARX517 trial; troublesome hot flashes are a flashpoint; picking the right GU med onc; starting immunotherapy while tapering on steroids; pectin supplements
Chat Log
Len Sierra sent · 5:28 PM Darolutamide inhibited the transcriptional activity of AR mutants identified in the plasma of CRPC patients progressing on traditional therapies. In particular, darolutamide significantly inhibited the transcriptional activity of the F877L, H875Y/T878A, F877L/T878A, and the previously unreported T878G AR mutants, that transform enzalutamide into a partial agonist.
John A sent · 5:33 PM Liu et al. Selective degradation of AR-V7 to overcome castration resistance of prostate cancer. Cell Death Dis. 2021
AnCan – rick sent · 5:38 PM Oliver Sartor now at Mayo
AnCan – rick sent · 5:49 PM Depo-Provera
George Southiere sent · 5:56 PM ACTH(adrenocorticotrphic) stimulation test = patient given ACTH and adrenal gland function is assessed- usually done by Endocrinologist
John A sent · 5:57 PM thanks
George Pat Martin sent · 6:00 PM I’m worn out. Gonna log off . be back next week
AnCan – rick sent · 6:04 PM Venlafaxine
Len Sierra sent · 6:05 PM https://embrlabs.com/products/embr-wave-2
AnCan – rick sent · 6:07 PM Embr watch.. d/c
Ancan50 sent · 6:07 PM Depo provera
George Southiere sent · 6:08 PM Gabapentin has helped me due to my severe neuropathy and has helped the hot flashes for me
sent · 6:09 PM I take 600mg gabapentin 3 times a day now. It never helped with my hot flashes.
Len Sierra sent · 6:37 PM modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:39 PM 1. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study
Len Sierra sent · 6:40 PM https://pubmed.ncbi.nlm.nih.gov/14663471/
Salvador sent · 6:43 PM Thank You for your feedback.
Chip & Jane sent · 6:48 PM G’nite All.. thanks for the fine discussion.
George Rovder, Arlington VA sent · 6:52 PM Thank you all. Good Night.
Salvador sent · 6:53 PM Thank You everyone, I learned a lot tonight
Terrill SF sent · 6:53 PM Thank you all. Good Night.
Hi-Risk/Recurrent/Advanced PCa Video Chat, June 13, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant & Telix
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/
Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s pick: Prostatectomy after 70. Also: Pluvicto wiped out 99% of his cancer — time for a jig! (bn)
Topics Discussed
Metformin’s faded glory in PCa treatment; grateful for heads-up on Xgeva with radium-223; statins and PCa — still anybody’s guess; darolutamide monotherapy might cut fatigue; curious about new hot-flash drug for women; experience with Onco360 pharmacy; when will white blood cells rebound from radiation; bike seats and PCa; seeing metastasis in lymph nodes that radiation skipped; dry mouth and depression overshadow wild Pluvicto success; too old for prostatectomy?; Keytruda and more Keytruda.
Chat Log
Steve in MI · 6:09 PM
Suttons Bay is nice; my wife has a few properties she manages up there. We get to Interlochen at least 2 or 3 times during the summer for concerts. Styx is the next one.
Steve in MI · 6:13 PM
There is a few up around here in the summer: Charlevoix, Fish Town, Elk Rapids. Ours is in August I think.
Julian – Houston · 6:18 PM
stopped taking because it made my bones ache!
Gary P · 6:20 PM
While not actually diabetic, I was put on Metformin after my blood sugar levels went up significantly on Abiraterone.
Julian – Houston · 6:24 PM
Same here, Gary. Took for awhile and my A1C came down.
AnCan – rick · 7:33 PM
“Patients received Pluvicto 7.4 GBq (200 mCi) every 6 weeks for up to a total of 6 doses plus BSoC or BSoC alone.”
BSoC = best standard of care
Tom Maloney · 7:34 PM
The recommended Pluvicto dose is 7.4 GBq (200 mCi) intravenously every 6 weeks for up to 6 doses, or until disease progression or unacceptable toxicity.
Tom Maloney · 7:34 PM
up to 6 doses, not requiring 6 doses.
AnCan – rick · 7:34 PM
The trials all gave 6 doses
Len Sierra · 7:36 PM
Tom, the dry mouth usually resolves by itself soon after your treatment is complete.
AnCan – rick · 7:38 PM
We do not know anyone who did less than 5 doses by choice. Doesn’t mean there aren’t any. However your doc is recommending you finish up.
AnCan – rick · 7:39 PM
We’ve seen less than 6 doses but only where blood counts or other markers have been compromised.
AnCan – rick · 7:45 PM
Xgeva = denosumab
Steve in MI · 7:52 PM
Keep coming back Spencer.
? · 7:52 PM
Thank you to everyone for excellent advise.
Joe (Dubois WY) · 7:59 PM
keytruda
Julian – Houston · 7:59 PM
Keytruda
Julian – Houston · 8:00 PM
Thanks guys. Another great session.
Hi-Risk/Recurrent/Advanced PCa Video Chat, May 9, 2023
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s pick: Rural denovo metastatic man 6 years out thrives with high PSA … but needs a GU med onc all the more! (rd)
Topics Discussed
Denovo Mx man thrives for 6 years with high double digit PSA; post-ADT, the T’s coming back!; small PSA increase on Pluvicto doesn’t mean failure; single session palliative spot RT + Bx to check disease; T slowly rising on mono daro; starting Xofigo to combat PSMA +/- PCa; what does Dr. A have in store for our BRAF man?; Mayo man moves to Sartor; hard to come by PSMA scan deferred until PSA rises; TMB vs PSMA vs PSA; can you start HT on mono daro?; quick review of CancerABCs conference.
Chat Log
Len Sierra sent · 3:09 PM Does Medicare insurance cover EMBR?
Frank Fabish Columbus OH sent · 3:09 PM I’m not sure
Vic St. Louis, MO sent · 3:10 PM I think only if prescribed by MD as medically necessary
John A sent · 3:27 PM genito-urinary medical oncologist
