Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/5/26
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HEADSUP – another long session!
Editor’s Pick: Like London buses, topics come in clusters this week – post-surgery recurrence, and monotherapy daro
Topics Discussed
Recurrence 3+ months post-surgery is confusing given medical reports; sitting on hands post 2017 RRP has dire cinsequences; more rapid recurrence requires PSMA scan for younger Gent; low T post treatment raises question whether to force it castrate; oxybutinin manages hot sweats… ARSI makes no difference; Gent considers going from doublet to mono; recently diagnosed denovo Mx man learns he’s 5+4; should he keep one Pluvicto session in reserve?; get a DEXA scan before starting bone stregthener; can a layman read their PSMA scan?; is he ready for mono daro?; should a FAP (Fibroblast Activation Protein Inhibitor) scan be considered?; PSMA needed as PSA rises post IHT; connections between prostate and thyroid cancer; Gent resumes doublet but doesn’t watch PSA – more concerned with duration?!?
Chat
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RJ Smith (Seattle) sent: 6:17 PM
Hey Bob! Infusion tomorrow, so today is a good day. Sucked on a lot of ice for round #2 as you recommended, so mouth/taste was fine. Proctitis (mostly damage from ton of radiation) is pain in the a**, though–quite a bit of pain this time, but no pain today, so I’ll take it!
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AnCan – rick sent: 6:24 PM
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Jim Marshall, Veteran, Alexandria, VA sent: 6:26 PM
When you update the Website with your info, do not enter any name of the doctor. This will be between you and Promise. Jim
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AnCan – rick sent: 6:45 PM
Alan Bryce https://www.cityofhope.org/alan-bryce
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Len sent: 6:56 PM
Orgovyx – relugolix
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Jeff Marchi – San Francisco sent: 6:58 PM
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Thomas Matica sent: 7:00 PM
Bayer Patient Assistance Foundation could provide free Nubeqa (darolutamide) if you qualify. https://www.patientassistance.bayer.us/en/ I am on my third year in the program.
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Len sent: 7:06 PM
https://jamanetwork.com/journals/jamaoncology/fullarticle/2784215?resultClick=1 Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer
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Jim Akin sent: 7:06 PM
House guest, must go. Thanks to AnCan and Rick D for referral to Dr. Guancial in Sarasota. Had great visit last week. ADT working, PSA May 4.7, today .01, no side effects, Testro 50. Orgovyx working
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Larry Schuller – Alaska sent: 7:06 PM
Orgovyx/relugolix pills and Firmagon/degalarix injections are both LHRH/GnRH ANTAgonists. In my opinion, superior to LHRH agonists, Lupron/leuprolide. Bot inferior (again, my opinion and personal experience) to trans-dermal estradiol (see the web site “estradiolinitiative.org” for more information or cantact me directly at ljschulr@alaska.net.
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Bob Schwartz U.S.N. Venice, FL. sent: 7:07 PM
Jeffrey Green, you can also get the Embr Wave at Amazon (my wife got mine there).
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Jim Marshall, Veteran, Alexandria, VA sent: 7:08 PM
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AnCan – rick sent: 7:12 PM
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AnCan – rick sent: 7:13 PM
- AnCan – rick sent: 7:15 PM
- Dr. S https://www.uchicagomedicine.org/find-a-physician/physician/russell-szmulewitz
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Jim Stewart Reno, NV sent: 7:24 PM
Family commitment have to sign off…Happy New Year everyone
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Jim Marshall, Veteran, Alexandria, VA sent: 7:36 PM
My solution for HOT FLASHES at night has been is even if the room is 55, I have a 12″ fan blowing directly on my face. This is done year round.
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Paul Schomer sent: 7:50 PM
I am not, no, Jim
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RJ Smith (Seattle) sent: 7:50 PM
NTD–will update next week on how Chemo#3 goes (docetaxel infusion tomorrow, fingers crossed).
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Thomas Matica sent: 8:07 PM
Leaving the meeting. Thanks to everyone. Happy New Year.
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Jim Marshall, Veteran, Alexandria, VA sent: 8:11 PM
Eric – When you are fatigued, go out and exericse despite the body telling you NOT!!!!
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S. Datta sent: 8:14 PM
FAPI (Fibroblast Activation Protein Inhibitor)
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Larry Schuller – Alaska sent: 8:18 PM
It is not crazy to want your testosterone back. Intermittent ADT can do that and it is showing promise as a tactic. Bipolar ADT (BAT) is a little crazier, but has some promise also. If you want to go wild, check out Dr Robert Gatenby’s work at Moffit in Florida. Intersesting stuff there.
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John G. sent: 8:19 PM
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AnCan – rick sent: 8:20 PM
PSMA + BCR trial https://www.clinicaltrials.gov/study/NCT05588128
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Jeffrey Green sent: 8:23 PM
Jay Mills Chatanooga- Though I didn’t follow the whole conversation, I heard you say something to the effect of, “I may have mets all over the place, in addition to what shows on PSMA.”
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Barry Blomquist sent: 8:28 PM
Have to jump – thanks everyone. Happy New Year
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Eric Curtis sent: 8:30 PM
Thanks all – gotta go
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Jeffrey Green sent: 8:31 PM
Got to start winding down here. Thanks for all you guys. See you next time.
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Len sent: 8:34 PM
Source is AI: Bidirectional Risk: Men diagnosed with thyroid cancer have a roughly 28% to 30% higher risk of later being diagnosed with prostate cancer compared to the general population. Conversely, men with prostate cancer are more likely to be diagnosed with thyroid cancer.
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Robert sent: 8:35 PM
Thanks Len. I read the same thing.
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dan-s sent: 8:49 PM
Thanks all… another good session. Have to sign off for the evening. Happy New Year…
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Jay T in MN sent: 8:50 PM
My hospital was charging the insurance company about $20,000.
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gary peters sent: 8:50 PM
I did not know this about thyroid C and PC. Thank you.
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Jon McPhee Toronto sent: 8:50 PM
Do a PSA test once a month. Cheap. PSMA/PET is expensive and harder to get.
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Jay T in MN sent: 8:51 PM
I “only” had to pay $1000 for my portion of PET PMSA