Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

Happy New Year – to learn more about what AnCan has achieved in the past 12 months, please visit https://mailchi.mp/ancan/ancans-year-end-summary

We also learned recently that in 2021 almost 15,000 visitors have watched 258,000 minutes in viewing time on our YouTube Channel – THANK YOU!

All AnCan’s groups are free and drop-in – join us in person sometime! You can find out more about this and our other 10 monthly prostate cancer groups at https://ancan.org/prostate-cancer/

To sign up to receive a weekly Reminder/Newsletter for this Group or others, go to https://ancan.org/contact-us/

Editor’s Pick: We all know this group is for men living with advanced prostate cancer. It’s also for men lviing with advanced bladder cancer …. listen in to find out why! (rd)

Topics Discussed

PROMISE may be the ticket; advanced bladder cancer may not be so different from PCa; disease recurs after 20 years; Provenge on the Islands; dexamethasone vs prednisone with abi; dex and heart rate; nocturia and how to deal with it; Agent Orange and otehr VA issues; BAT experience; entering hospice; GU Med Onc recommends RT

Chat Log 

Herb Geller (to Everyone): 4:10 PM: On a Mac, the chats are in Documents>GoToMeeting Chats

Peter Kafka (to Everyone): 4:13 PM: psma scan time

Peter Kafka (to Everyone): 4:15 PM: Oliver Sator at Tulane would be a good option.

Carl Forman (to Everyone): 4:18 PM: I had tried to get a telemed appt with Sator for a second opinion, but was told he only sees new patients in person.  Didn’t want to get on a plane to see him.

John Antonucci (to Everyone): 4:20 PM: HIya Jake

Jake Hannam (to Everyone): 4:20 PM: pylarify

Alan Moskowitz (to Everyone): 4:22 PM: Could he have had C 11 Choline  scan?

Joe Gallo (to Everyone): 4:27 PM: Invitae

Jake Hannam (to Everyone): 4:28 PM: I might have some input on oxycodone. I’m an old pro.

Julian Morales-Houston (to Everyone): 4:30 PM: I got the Color this week?

Bill Lewis (to Everyone): 4:34 PM: I’ve done more than 8000 self catheterizations. lewis.bill@gmail.com

AnCan – rick (to Everyone): 4:45 PM: You ain’t going to hear this type of stuff anywhere else, Gents!!!

Alan Moskowitz (to Everyone): 4:48 PM: Avoid any gas causing foods –

Mark Horn (to Everyone): 4:53 PM: Many thanks everyone

Bill Lewis (to Everyone): 5:02 PM: To Steve: my oncologist would give you a special version of Chemo, including Taxotere and 2 other drugs right away. Love to talk.

Jake Hannam (to Everyone): 5:02 PM: axumin       PSMA Pet

Vic (to Everyone): 5:05 PM: from the PEACE 1 study/trial and be sure to talk with the GU MO

Erwin Zoch (to Everyone): 5:10 PM: I suggest that unfamiliar acronyms be defined when 1st used for newcomers e.g,, SBRT is Stereotactic Body Radiation Therapy (or RadioTherapy).

Bob Smith (to Everyone): 5:12 PM: Regarding Steve’s comment on head bump, is it common for concussions to lead to PCa brain or other?

Herb Geller (to Everyone): 5:13 PM: I have not seen any suggestion that a concussion can promote a PC metastasis

Peter Kafka (to Everyone): 5:13 PM: I have never heard of incidents like this leading to cancer metastasis.  But I am no expert.

AnCan – rick (to Everyone): 5:16 PM: Bob – not sure there is any correlation that I have heard of.PCa spreads without any interference from outside forces – unfortunately.

Steve Barber (to Everyone): 5:22 PM: My imaginatve, “pet” theory is that 35 years of cell phone use/radiation conpromised the integrity of bone in my skull on the right side.

Vic (to Everyone): 5:24 PM: what study supports the abi with meals?

Jake Hannam (to Organizer(s) Only): 5:30 PM: bone scans are notoriously insensitive

AnCan – rick (to Everyone): 5:31 PM: Vic – we have articles around abi with food.  But only re. reducing the dose with food.

Jim Marshall, Alexandria, VA  (to Everyone): 5:41 PM: Jiimmy – Count your blessings you ARE.   Think of what happens if you are not.    Jim Marshall

Joel Blanchette, Reston VA (to Everyone): 5:41 PM: I am on the exact schedule as Jimmy and Herb.

Julian Morales-Houston (to Everyone): 5:42 PM: This is my schedule to a T!

Stan Friedman (to Everyone): 5:43 PM: I have obstructive sleep apnea and the therapy reduces the number of times I get up to one, maybe two.

Vic (to Everyone): 5:44 PM: I’ve had some success just ignoring the urge to go an being able to fall back to sleep without leaking

AnCan – rick (to Everyone): 5:44 PM: Myrbetriq

Bill Lewis (to Everyone): 5:47 PM: Food added to full-dose Zytiga: PMID 25777155; DOI: 10.1038/pcan.2015.7 — Bill Lewis

Steve Barber (to Everyone): 5:47 PM: Thanks to all!  At this time I must get off the meeting.  I look forward to another visit and appreciate all the input today. Steve

AnCan – rick (to Bill Lewis): 5:49 PM: Tx Bill – we will definitely take a look at the refernce. I am sure Len and Herb are on it.

Len Sierra (to Organizer(s) Only): 5:51 PM: I just did.  2015 study with 41 patients.  They claim 16% better response on food with full dose.  No increase in tox.  Hard to believe.

Len Sierra (to Organizer(s) Only): 5:53 PM: I’d need to read the full paper.  And see if anyone was citing this study.

Herb Geller (Private): 5:53 PM: IT is a small retrospective study from 2015,  They say that abi with food lowered T, so there must have been an issue with their initial therapy.

AnCan – rick (to Organizer(s) Only): 5:53 PM: Maybe you can look closer ….. But even so, changing dose like that must inc. medical advice.   Did these men fail abi then up the dose.

Herb Geller (to Organizer(s) Only): 5:54 PM: T is a small retrospective study from 2015, They say that abi with food lowered T, so there must have been an issue with their initial therapy.  It is totally flawed

Peter Kafka (to Everyone): 5:55 PM: Don’t forget the water quality at Fort Bragg

Jake Hannam (to Everyone): 5:57 PM: Military water quality is notoriously bad and still being EPA-remediated across  the country

Herb Geller (to Everyone): 5:59 PM: I looked at the abstract of the study. Thay say that abi with food caused a decline in T levels as well as PSA in a small percent of men. The fact that T declined suggests they were undertreated before switching to food. T should be undetectable with any effective dose of abi

Joe Gallo (to Everyone): 6:01 PM: Veterans Population ~19,000,000

Veterans in VHA System ~9,000,000

Veterans in VHA with Prostate Cancer 488,984

Veterans in VHA with Metastatic Prostate Cancer 16,282

Veterans diagnosed with Prostate Cancer each year ~15,000

Cumulative (10year) Cost of High Risk PCa Patient2

~$200,000

Total Economic Burden for High-Risk Patients in VHA ~$3,256,400,000

Vic (to Everyone): 6:02 PM: Is a vet rep needed for St. Louis, MO.? If so, who should be contacted?

Joe Gallo (to Everyone): 6:03 PM: Vic and anyone interested let me know and I will forward the info.    joeg@ancan.org

Vic (to Everyone): 6:04 PM: please do Joe, thanks

Vic (to Everyone): 6:14 PM: the nasa astronauts used a penis prosthesis for urinating, perhaps that would be available and helpful for you Jake

Erwin Zoch (to Everyone): 6:15 PM: Thanks to all of you for this amazing information!  Thanks to Jay for encouraging me to join this group.  I hope to be with you again soon.

Jay Mills (to Everyone): 6:16 PM: Best of luck tomorrow Erwin with your appointment.

Peter Monaco (to Organizer(s) Only): 6:18 PM: Need to sign off gents! I will handle all recordings this week. Best regards and Happy New Year!

Jake Hannam (to Organizer(s) Only): 6:19 PM: you too peter and thanks for your help

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 20, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 20, 2021

 

Happy Holiday Season to all – to learn more about what AnCan has achieved in the past 12 months, please visit https://mailchi.mp/ancan/ancans-year-end-summary

We also learned recently that in 2021 almost 15,000 visitors have watched 258,000 minutes in viewing time on our YouTube Channel – THANK YOU!

All AnCan’s groups are free and drop-in – join us in person sometime! You can find out more about this and our other 10 monthly prostate cancer groups at https://ancan.org/prostate-cancer/

To sign up to receive a weekly Reminder/Newsletter for this Group or others, go to https://ancan.org/contact-us/

Editor’s Pick: This week, it’s a theme – men who are clearly their own best advocate and men who just ain’t….. and don’t let a handful of difficult customers deter you (rd)

Topics Discussed

Foundation Medicine’s Next Generation Sequencing liquid biopsy ; ‘Be You Own Best Advocate; looking to bike like Dad for another 30 yrs ….at 59 ; get best information to make intial treatment decision; everone else responsible for this man’s PCa except him; when to intorduce 2nd line anti-androgen and which one; and more … abi vs enz; finishing salvage RT; let’s talk about soy; explaining RT ligands/radionuclides; yup – that pain in the neck is PCa; cabazitaxel – hopefully the plateau before the drop; holding the course with pembro despite no result; blood pressure issues; Lu177 PSMA’s a winner for this v. grateful man; palliative care, hospice or what?

Chat Log

Joe Gallo (Private): 6:08 PM: What about SelectMDx?

AnCan – rick (to Joe Gallo): 6:09 PM: ???? – explain Joe

Joe Gallo (Private): 6:11 PM: Urine based test that confirmed the probability that I had greater than Gleason 7. Proceeded to TP.  A favorite of E David Crawford

ALFRED LATIMER (Private): 6:12 PM: Rick. I forget. Who does the liquid biosy?

Jake Hannam (to Everyone): 6:13 PM: ty carl – i do have a brief update but no news

Joe Gallo (Private): 6:13 PM: Measures 2 mRNA cancer related biomarkers

AnCan – rick (to ALFRED LATIMER): 6:14 PM: Foundation Medicine

AnCan – rick (to Organizer(s) Only): 6:19 PM: He is high risk with PSA 22 but borderline

Jimmy Greenfield (Private): 6:19 PM: Thirty years! I like his optimism

Len Sierra (to Everyone): 6:19 PM: Crude incidence of individual secondary cancers ranged from 0.2% to 2.3% for patients treated with external beam radiotherapy, 0.1% to 2.1% for patients treated with brachytherapy, 0.2% to 1.7% for patients treated with brachytherapy and external beam boost, and 0.3% to 2.3% for patients not exposed to radiotherapy  BMJ. 2016; 352: i851. Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis

George (to Everyone): 6:24 PM: https://www.mskcc.org/nomograms/prostate

Warren in Edmonton (to Everyone): 6:24 PM: If Len would like to chat with me after the meeting please let me know, I can offer a great deal of information on his question

Peter Kafka (to Organizer(s) Only): 6:24 PM: He should get a second opinion on his biopsy with this one

George (to Everyone): 6:24 PM: https://riskcalc.org/PBCG/

Joe Gallo (to Everyone): 6:26 PM: Epstein Consult https://hopkinsconsults.org Eric. Just ask you urologist to send. You don’t have to track down your slides

Eric Madison, WI. (to Everyone): 6:35 PM: Have a great night, guys!

Joe Gallo (to Organizer(s) Only): 6:35 PM: He will get a good discussion when he chats with Epstein

Pat Martin (to Everyone): 6:36 PM: I was dxed and had at least 6 weeks before sugery. They gave me casodex and Lupron

Joe Gallo (to Everyone): 6:42 PM: joeg@ancan.org

Jake Hannam (to Everyone): 6:42 PM: This a better link on the GA-68 approval: https://www.pcf.org/blog/breaking-news-kit-for-psma-pet-imaging-agent-gains-fda-approval/ ga-68 psma kit approval

Len Sierra (to Organizer(s) Only): 6:47 PM: What was Warren’s GL?

AnCan – rick (to Everyone): 7:14 PM: Foundation Medine Canada https://www.foundationmedicine.ca/ WARREN – here’s your BC GU Med Onc https://medicine.med.ubc.ca/profiles/kim-nguyen-chi/

Warren in Edmonton (to Everyone): 7:24 PM: I have a small emergency at home and I must leave the meeting. Merry Christmas to all.

Len Sierra (to Everyone): 7:45 PM: Soy might lower the risk of other cancers

Studies among prostate cancer survivors indicate that eating soy foods may lower PSA levels. Among men in various stages of prostate cancer, those who consumed soy milk or isolated soy isoflavones saw their PSA levels rise at a slower rate. Source for my post: www.nutritionfacts.org

AnCan – rick (to Everyone): 7:47 PM: Greta Macaire on AnCan https://ancan.org/nutrition-prostate-cancer/

Harry (to Everyone): 7:47 PM: some research says soy helps reduce hot flashes

AnCan – rick (to Everyone): 7:48 PM: UCSF Nutrition Pamphlet http://urology.ucsf.edu/sites/urology.ucsf.edu/files/uploaded-files/attachments/nutrition_and_prostate_cancer.pdf

Alan Moskowitz (to Everyone): 7:48 PM: Regarding Enza  vs Abi – my MO at MSK said “As for abi vs enzalutamide, as we discussed, never been compared head to head though my feeling is enzalutamide is a bit more active. Though they work differently, both have very high response rates up front but much lower when the other has already been used. In “switching” trials, enza has higher response rate after abi than abi after enza. To me, this doesn’t mean starting with abi is better. It’s just consistent with enza being the more active drug (easier to become abi resistant than enza resistant). But overall, it’s a tossup and I give abi to more elderly and frail and enza to younger and healthier. Essentially no difference between enzalutamide and apalutamide.”

Stan Friedman (to Everyone): 7:48 PM: https://www.aicr.org/resources/blog/soy-and-cancer-myths-and-misconceptions/

Alan Moskowitz (to Everyone): 7:49 PM: I have to leave,  thanks for the guidance.

AnCan – rick (to Everyone): 7:49 PM: Alan – this NOT about head-to-head; it’s about sequencing

John Antonucci (to Everyone): 8:02 PM: will they  give a 2nd booster?

Len Sierra (to Everyone): 8:04 PM: They will give a second booster to immunocompromised folks.

Cal Van Zee (to Everyone): 8:12 PM: My blood pressure peaked at 200/100 on prednisone on 50mg Losartan w/o diruetic.  After changing to dexamethasone, BP dropped to normal and I stopped Losartan.

Cal Van Zee (to Everyone): 8:17 PM: 120/80 or below: for me it was the Prednisone, not the AbiI’m still on Abi now but my PSA is rising now at 19.  Most likely starting chemo first week of Jan

Jerry Pelfrey (to Everyone): 8:19 PM: Sorry I have to leave.  Have a Great Christmas!

Julian Morales-Houston (to Everyone): 8:24 PM: Merry Christmas to all!

Stan Friedman (to Everyone): 8:24 PM: Merry Christmas!

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

CORRECTED: Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 14, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 14, 2021

(apologies ….. my error on the date first time ; tx to David Muslin for pointing it out. rd)

Happy Holiday Season to all – to learn more about what AnCan has achieved in the past 12 months, please visit https://mailchi.mp/ancan/ancans-year-end-summary

We also learned this week that in 2021 almost 15,000 visitors have watched 258,000 minutes in viewing time – THANK YOU!

All AnCan’s groups are free and drop-in – join us in person sometime! You can find out more about this and our other 10 monthly prostate cancer groups at https://ancan.org/prostate-cancer. To sign up to receive a weekly Reminder/Newsletter for this Group or others, go to https://ancan.org/contact-us/

Editor’s Pick: Is palliative care the right call or should it be hospice? We also pick apart the abi steroid recommendations. (rd)

Topics Discussed

Abi fails for denovo Mx Newbie; setting up a medical team away from home; best steroid protocol for abi; Pylarify is widely available – advocate for it; palliative vs hospice care and when to switch; abi fails for denovo Mx Oldie!; high risk man needs to watch the urologist pushing surgery; is a new ‘bone drug’ right for PCa?; cabzitaxel maintains stability – no significant results yet; Novartis/AAA helps our guy get into 2nd Lu177 trial; Ac225/pembro trial not producing results.

Chat Log

Mark Perloe, MD Atlanta (Private): 4:22 PM: If the tissue is negative shouldn’t germline be negative as well?

AnCan – rick (to Mark Perloe, MD Atlanta): 4:24 PM: Yup – exactly; but there may be a lot more in his somatic test

Mark Perloe, MD Atlanta (Private): 4:25 PM: too many different companies offering different tests.

Len Sierra (to Everyone): 4:52 PM: My AnCan blog on comparisons of glucocorticoid regimens with Zytiga / abiraterone: https://ancan.org/safety-of-glucocorticoid-regimens-in-combination-with-zytiga-for-mcrpc-patients/

Jim Marshall – Alexandria, VA (to Everyone): 4:57 PM: was just switched from 10 to 5mg per day because the current recommendaition from Janssen for CSPC is 5mg and CRPC is 10 mg

James Barnes (to Everyone): 5:01 PM: Thanks Jim. Just checked and my dosage is 5mg as well.

Stephen Saft (to Everyone): 5:04 PM: According to Pylarify website is available in Minneapolis. https://www.pylarify.com/ordering-and-reimbursement

Herb Geller (to Organizer(s) Only): 5:04 PM: Based on Jim’s comment should I take 10 mg of prednisone

Len Sierra (to Organizer(s) Only): 5:07 PM: I would, Herb.

AnCan – rick (to Organizer(s) Only): 5:09 PM: I have never heard that difference …. 5mg vs10 mg. That said – my advice would be to discuss with your doc, Herb

Herb Geller (to Organizer(s) Only): 5:15 PM: The package insert for CRPC says 5 mg twice a day.

Len Sierra (to Organizer(s) Only): 5:17 PM: Herb, Jim said Janssen says this is the current recommendation (10mg). Why not call them?

AnCan – rick (to Organizer(s) Only): 5:17 PM: That was the original approval; since then 5 mg seems acceptable as you saw. Only one person takes 10 mg

Len Sierra (to Organizer(s) Only): 5:25 PM: Did Larry Fish say Hospice will not “allow” any care, even pain relief?? That doesn’t sound right.

Herb Geller (to Organizer(s) Only): 5:26 PM: They will do pain relief but not continue survival meds

Peter Kafka (to Everyone): 5:26 PM: All hospice care is different

AnCan – rick (to Organizer(s) Only): 5:27 PM: Hospice always allows pain meds

Herb Geller (to Everyone): 5:27 PM: Stadium Pal

Pat Martin (to Everyone): 5:28 PM: External catheter worked for me so I could get out and about. External hocked to tubes and a leg bag.

Cal Van Zee (to Everyone): 5:36 PM: Herb: My counselor taught me the future doesn’t exist, only now. FEAR stands for future events appear real. I choose every day to be grateful that I’m here today.

Stephen Saft (to Everyone): 5:39 PM: Eckhart Tolle writes on this. Book called the Power of Now is fantastic.

Len Sierra (to Everyone): 5:40 PM: Yes, I read that book and it is excellent.

Stephen Saft (to Everyone): 5:42 PM: To a man with a hammer everything looks like a nail. Urologist is not the only one to listen to in this situation.

Pat Martin (to Everyone): 5:54 PM: What I did is contact the practice I was transferring to and they contacted my local urologist. And it happened without my involvement

Julian Morales – Houston (to Everyone): 5:54 PM: Got another meeting to go to. always good meetings. thank you

Stephen Saft (to Everyone): 5:55 PM: I got in the habit of taking a disk copy with me whenever I get a scan.

Jake Hannam (to Everyone): 6:00 PM: I love all you guys. Just saying …

Jim Ward (to Everyone): 6:00 PM: Evenity (romosozumab)

Pat Martin (to Everyone): 6:02 PM: gotta run. Catch everyone next week

Peter Monaco (to Everyone): 6:02 PM: Right back at ya Jake!

Herb Geller (to Everyone): 6:05 PM: Romosozumab causes ONJ equivalent to others

Jim Ward (to Everyone): 6:07 PM: Thanks, Herb.

Paul Freda Florida (to Everyone): 6:17 PM: Have an online Calculus lesson to do. See y’all next week.

Jake Hannam (to Everyone): 6:20 PM: take care Paul!

Special Presentation: Exercise After Prostate Cancer: Active Surveillance and Beyond

Special Presentation: Exercise After Prostate Cancer: Active Surveillance and Beyond

On December 1st, we had Dr. Kerry Courneya (Professor, Faculty of Kinesiology, Sport, and Recreation at University of Alberta) give a talk to our AS group titled “Exercise After Prostate Cancer: Active Surveillance and Beyond

Dr. Courneya had one message: Don’t take your cancer laying down.

He maintained that research has shown “exercise is the single most important thing” a cancer patient can do—even more important than diet.

His research has shown patients with prostate cancer (low-risk to high-risk), lymphatic cancer, and other cancers benefit from exercise.

The most recent study by his group in Edmonton, appearing in JAMA Oncology, showed for the first time that High Impact Intensity Training–bursts of exercise rather than a continuous approach—can help suppress the growth of prostate cancer cells in men on active surveillance. (https://jamanetwork.com/journals/jamaoncology/fullarticle/2783273)

The ERASE study was the first randomized controlled trial to examine the effects of exercise in men with prostate cancer on AS.

There’s more to the exercise story than suppressing prostate cancer. The biggest risk to men with low-risk prostate cancer is heart disease. The study showed that not only does exercise suppress prostate cancer cells but it also helps with cardiac measures.

He said also exercise relieves anxiety and depression, helping men stay on AS longer.

“Exercise is a win-win.” he said.

Short exercise videos can also be found on Pfizer’s site “This Is Living With Cancer” .

Watch here:

 

To view the slides from this presentation, click here.

For information on our peer-led video chat ACTIVE SURVEILLANCE PROSTATE CANCER VIRTUAL SUPPORT GROUP, click here.

To SIGN UP for the Group or any other of our AnCan Virtual Support groups, visit our Contact Us page.

 

Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 28, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Nov 23, 2021

Hi-Risk/Recurrent/Advanced PCa Video Chat, Nov 15, 2021

All AnCan’s groups are free and drop-in – join us in person sometime! You can find out more about this and our other 10 monthly prostate cancer groups at https://ancan.org/prostate-cancer/

To sign up to receive a weekly Reminder/Newsletter for this Group or others, go to https://ancan.org/contact-us/

Editor’s Pick: AnCan is honored with the first time presence of a PCa doyen this week. Even he is overshadowed by conversation between two men with 60+ chemo treatments between them! (rd)

Topics Discussed

Snuffy lives through this PCa elder; testosterone supplementation; keep an eye on bone densitty; lo-fat abiraterone protocol; cryo alternative for spot Tx of lesion; GERD effects seveal of our guys; cabaziatxel + carboplatin protocol for small cell/NE disease; CEA as a marker; TP53 + PTEN cast suspicion on PCa type; diet may slow growth; is AUS causing fevers?; comparing notes on mutliple chemotherapies; drug holidays; lesions disappear with treatment …. but another shows up.

Chat Log

Larry Fish (to Everyone): 4:15 PM: lupron before casodex?

Joe Gallo (to Organizer(s) Only): 4:16 PM: PSMA?

Larry Fish (to Everyone): 4:18 PM: did they try stopping casosex?

Herb Geller (to Organizer(s) Only): 4:19 PM: Bless him! Getting tooth implants at 89!

Jake (to Organizer(s) Only): 4:20 PM: Is that BAT?

Len Sierra (to Organizer(s) Only): 4:20 PM: No, Andro-gel.

Herb Geller (to Organizer(s) Only): 4:20 PM: Its a modified BAT but it depends upon the dose of andro-gel

Jake (to Organizer(s) Only): 4:21 PM: thanks

AnCan – rick (to Organizer(s) Only): 4:24 PM: Not really BAT -BAT uses extremes and swamps AR receptors. This is a crazy Snuffy protocol

Pat Martin (to Everyone): 4:25 PM: Any genetic testing?

AnCan – rick (to Everyone): 4:26 PM: This Testosterone Tx is highly controversial!!

Jimmy Greenfield (Private): 4:27 PM: Snuffy Myers has left quite a footprint! I almost feel like I know him.

AnCan – rick (to Jimmy Greenfield): 4:28 PM: Some crazy ideas and some that proved viable

Dennis Correia (to Everyone): 4:51 PM: Journal of Clinical oncology March 28, 2018 for info the Abi low dose with low fat breakfast.

Len Sierra (to Everyone): 4:51 PM: From Dr. Russell Szmulewitz, (U Chicago) director of the clinical trial showing equivalent effectiveness of Zytiga with food at ¼ the dose with a low fat meal. Abiraterone, approved in 2011 for the treatment of metastatic prostate cancer, has a “food effect” that is greater than any other marketed drug. The amount of abiraterone that gets absorbed and enters the blood stream can be multiplied four or five times if the drug is swallowed with a low-fat meal (7 percent fat, about 300 calories). That can increase to 10 times with a high-fat meal (57 percent fat, 825 calories).

Pat Martin (to Everyone): 4:52 PM: I was under the impression that the docs did not think the patients would follow precise instructions.

Jake (to Organizer(s) Only): 4:56 PM: omeprazole (Zantac?) might be the answer

Joe Gallo (to Organizer(s) Only): 4:57 PM: Prilosec

Jake (to Organizer(s) Only): 4:58 PM: right! thanks Joe.

Herb Geller (to Organizer(s) Only): 5:03 PM: I just read an article that CEA with PC is a very bad prognostic factor

Len Sierra (to Organizer(s) Only): 5:04 PM: I agree, Herb.

Herb Geller (to Organizer(s) Only): 5:05 PM: Although another paper says there is no correlation with OS. So no real data.

Herb Geller (to Everyone): 5:14 PM: Initial Management of Noncastrate Advanced, Recurrent, or Metastatic Prostate Cancer: ASCO Guideline Update Abiraterone 250 mg daily with a low-fat breakfast has been examined as an alternative to abiraterone 1,000 mg on an empty stomach for men with metastatic castration-resistant prostate cancer (CRPC) and was shown in a small phase II trial to be noninferior based on the PSA response rate over 12 weeks…….. read more at https://ascopubs.org/doi/pdf/10.1200/JCO.20.03256

Walter Dardenne (to Everyone): 5:51 PM: I have to leave, Happy Thanksgiving to everyone.

AnCan – rick (to Everyone): 5:51 PM: Same to you Walt – tx for coming

AnCan – rick (to Everyone): 5:52 PM: where else can you hear two guys speak with so much chemo under their belt!?!

Joel Blanchette, Reston VA (Private): 5:54 PM: OK

Stephen Saft (to Everyone): 5:55 PM: I have a friend who has PSA in the 1500-2500 range. He has had few symptoms of the disease and no metastatic disease.

Pat Martin (to Everyone): 5:57 PM: Ya’all have a great Thanksgiving. Gonna run. See you next week

AnCan – rick (to Jim Ward): 6:08 PM: I’m telling Alexa that your pussy cat showed up on the call