Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024 

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

View AnCan’s patient-centered selection of papers and presentations from ASCO GU 2024, one of the top conferences on prostate cancer treatment: • ASCO GU 2024 conference highlights https://www.youtube.com/watch?v=YweU8hjA0Lw&t=2s

AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.

AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare Navigation… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: Calcium, bone strengtheners and 2 Newbies with different approaches – one at the end.(rd)…. & FYI it’s Len’s B-day today (3/19)!!

Topics Discussed

4+5 Newbie does well on first treatment protocol; caffeine issues; Space Oar; 14x Jevtana Tx… and another foamy gland compatriot; does HT kill cancer cells or just make them dormant?; pros and cons with balancing calcium; which 2nd line AA to start with; great discussion on bone strengtheners; avoid 6 month Depot LHRH; started Pluvicto; this latecomer Newbie self medicates

Chat Log

  • TonyFig

    sent: 6:04 PM

    Calcium connection with AFib. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782034/

  • Jim Marshall, Alexandria, VA

    sent: 6:07 PM

    There goes my Ice Cream.

  • AnCan – rick

    sent: 6:09 PM

    She is a GU med onc

  • AnCan – rick

    sent: 6:18 PM

    Dr. Jeff – you do NOT want to be on a 6-month shot!

  • Dr. Jeff

    sent: 6:21 PM

    thanks, what’s the drawback of 6 month Eligard?

  • Don Rogers

    sent: 6:22 PM

  • Frank Fabish Columbus OH

    sent: 6:23 PM

    abi dose in morning must wait an hour before eating

  • Don Rogers

    sent: 6:23 PM

    saw this today.

  • John A

    sent: 6:23 PM

    The concern is that the leuprolide might wear off a month early.

  • Dr. Jeff

    sent: 6:23 PM

    at 45 mg?

  • Dr. Jeff

    sent: 6:24 PM

    abiraterone one hr before food or 2 hrs after food

  • Don Rogers

    sent: 6:24 PM

    Scriptco.com abiraterone 120 pills of 250 mgs for 80.00 There is a yearly membership fee of $140

  • Jim Marshall, Alexandria, VA

    sent: 6:25 PM

    250mg Abiraterone with LOW-FAT foods.

  • Dr. Jeff

    sent: 6:38 PM

    are you referring to Aredia q 3 to 6 months infusion?

  • Dr. Jeff

    sent: 6:38 PM

    Pamidromate is Aredia

  • AnCan – rick

    sent: 6:39 PM

    Was thinking of a shot

  • AnCan – rick

    sent: 6:41 PM

    Boniva is the shot

  • Thomas Matica

    sent: 7:26 PM

    GOT TO SCOOT. THANKS ALL. THOMAS

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 12, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 12, 2024

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

View AnCan’s patient-centered selection of papers and presentations from ASCO GU 2024, one of the top conferences on prostate cancer treatment: • ASCO GU 2024 conference highlights https://www.youtube.com/watch?v=YweU8hjA0Lw&t=2s

AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.

AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare Navigation… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: Joint pain and muscle pulls on Pluvicto — how long till they fade? (bn)

Topics Discussed

JimmyG losing sleep over his sleep — others weigh in; small PSA changes and oversized worries; Dr. Elisabeth Heath holds her own with a jokester — but seriously, it’s time to go back on treatment; abiraterone caveats; sore joints and muscle pulls on Pluvicto — how long till they fade?; urinary blood clots 2 years after radiation — doc gives him a bladder tour; darolutamide monotherapy holds the fort, and the hot flashes are finally going away; announcing a new AnCan group for caregivers of people with neuromotor conditions — like Parkinson’s, multiple sclerosis, muscular dystrophy — to be led by Alexa; insurance nixes denosumab for his rapid-onset osteoporosis and insists on Zometa — what’s up with that?; back stateside after overseas visit for radioligand therapy and a brief course of PARP inhibitor — signals are good so far; results of a study (LuPARP) that looked at that combination.

Chat Log

AnCan – rick · 6:28 PM
Lorazepam Use Linked to Shorter PFS, OS in Several Cancers https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/lorazepam-use-linked-to-shorter-pfs-os-in-several-cancers

Jim Marshall, Alexandria, VA · 6:44 PM
Am Taking Pravastatin instead of Liptor or Crestor. Jim Marshall

Unknown · 7:10 PM
Did he say Pluvicto and Actinium?

Jim Marshall, Alexandria, VA · 7:10 PM
Brian, yews he did. jim

AnCan – rick · 7:11 PM
Pluvicto only

Jim Barnes · 7:12 PM
I did say Actinium & Lutetium

AnCan – rick · 7:13 PM
Jim B had both; Chuck S only Pluvicto

AnCan – rick · 7:17 PM
https://www.vumedi.com/video/biomarkers-and-biology-treatment-resistance-in-advanced-prostate-cancer

AnCan – rick · 7:18 PM
Dr. Lang’s presentation above.

AnCan – rick · 7:32 PM
denosumab vs zoledronic acid https://www.sciencedirect.com/science/article/pii/S221213741630063X#:~:text=Denosumab%20and%20zoledronic%20acid%20are,lung%20cancer%2C%20and%20multiple%20myeloma.

Steve Schuler · 7:42 PM
gotta leave. Thanks folks!

AnCan – rick · 7:54 PM
https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.5064

Paul Freda Lake Worth FL · 7:54 PM
I am just grateful that PCa is the most treatable and controllable Cancer.

AnCan – rick · 7:54 PM
LuPARP

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 27, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 27, 2024

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

In a special session before tonight’s meeting, we presented key papers from ASCO GU 2024, a major conference for doctors treating prostate cancer, and answered questions — details here.

If you missed our first 2024 webinar with GU med onc Dr. Oliver Sartor and nuclear medicine pioneer Dr. Phillip H. Kuo — “Radionuclide Diagnostics & Theranostics – Theory and Clinical Practice Meet!” – watch it at https://ancan.org/webinar-radionuclide-diagnostics-theranostics-theory-and-clinical-practice-meet

AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.

AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare Navigation… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: PSA rising but nothing on the PET scan – the tumor was hiding behind his bladder. (bn)

Topics Discussed

After beating back his cancer many times, he’s now neuroendocrine and wonders about options besides platinum (immuno, DLL3, alpha) — Dr. Rahul Aggarwal is likely to have answers; Tylenol on top of Orgovyx and darolutamide may have been one too drug too much for his liver; struggling to work remotely with Dr. E’s office team — you’ll need “a heavy dose of patience”; after 6 unhelpful chemo rounds, now seeing a good lutetium response, but unresponding tumors may be neuroendocrine; maximum out-of-pocket expense is the important number in choosing a Medicare Part D plan; trusting a broker for Medicare selection, and are Advantage plans a bad deal for cancer patients?; despite rising PSA, PSMA scan looked clear…turned out the tumor was hiding behind the bladder; good feedback on Dr. Elisabeth Heath; 90-day Lupron break to “catch my breath” — is restarting now a lost cause?; Lupron finally over, he’s switching back to a real bike from his e-bike…but when do the hot flashes stop?

Chat Log

Jim Marshall, Alexandria, VA · 5:34 PM
we all need to be our own best advocate at all times

Jim Marshall, Alexandria, VA · 6:05 PM
on a Macbook, I see all the names. without hovering

Len Sierra · 7:05 PM
Chromogranin A (CGA) and neuron-specific enolase (NSE) levels are biomarkers for NEPC. Also, synaptophysin and DLL3 (Delta-like Ligand 3) is positive in 76% of NEPC.

AnCan – rick · 7:06 PM
Contact: Garrett Crook 424-314-0745 Garrett.Crook@cshs.org Principal Investigator: Kanya Sankar, MD

AnCan – rick · 7:07 PM
DLL3 NCT04471727 https://classic.clinicaltrials.gov/ct2/show/NCT04471727?term=HPN328&cond=Prostate+Cancer&draw=2&rank=1

AnCan – rick · 7:14 PM
HPN328 is the DLL3 drug

AnCan – rick · 7:38 PM
Solo Arts Heal TOMORROW NIGHT rd + MARK KISSIN FRCS check https://ancan.org/solo-arts-heal/ for links to The Marsh page and join us on Zoom or YouTube

Thomas Matica · 7:54 PM
Did Rick say that there is video discussion on the insurance issues? I can’t find anything. Thanks.

AnCan – rick · 7:55 PM
Tom – search for Triage Cancer on our site

AnCan – rick · 7:56 PM
Here you go….. https://ancan.org/webinar-lets-talk-medicare-2024/

 

Patient Highlights from the 2024 ASCO GU conference

Patient Highlights from the 2024 ASCO GU conference

Patient Highlights from the 2024 ASCO GU conference

In a 75-minute “pre-game” before the 2/27/2024 meeting of the high-risk/recurrent/advanced prostate cancer group, moderators John, Rick, Ben, and Len discussed highlights from the just-concluded ASCO GU conference, a major meeting for genitourinary cancer specialists. They selected from hundreds of papers on prostate cancer presented in sessions and posters. We closed with a 30-minute audience Q&A.

What we covered:

  • Abi boosts olaparaib for BRCA
  • After triplet therapy, what next?
  • Less treatment, same cancer-fighting power
  • Trial of a neuroendocrine PCa drug
  • Prostate cancer and suicide
  • Germline & somatic testing is too infrequent
  • What treatments work after Pluvicto
  • Pluvicto flare largely lasts only one treatment
  • Community providers do poor job treating mCSPC men
  • Increased risk of a second cancer
  • Mixed evidence on concordance scans
  • Tumor growth without PSA rise
  • Toxicity/benefit tradeoffs for patients
  • Importance of PSMA PET Scan Concordance
  • APA PSA90 Better than ENZA in mHSPC?
  • APA PSA90 Better than ABI in mHSPC?
  • What’s the best prednisone dose with ABI?
  • OS based on the site of metastases
  • Paradigm for Sequencing PARPi with Lu-PSMA?

The evening’s slides are available at https://drive.google.com/file/d/18bH04PnXNEuKLmGLAq4aVHzDEzdSl1pf/view?usp=sharing

Hi-Risk/Recurrent/Advanced PCa Video Chat, Mar 18, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 13, 2024

Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 13, 2024

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

If you missed our first 2024 webinar with GU med onc Dr. Oliver Sartor and nuclear medicine pioneer Dr. Phillip H. Kuo — “Radionuclide Diagnostics & Theranostics – Theory and Clinical Practice Meet!”watch it at https://ancan.org/webinar-radionuclide-diagnostics-theranostics-theory-and-clinical-practice-meet

AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.

AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare Navigation… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: A penile prosthesis, and a lot of new hips. (bn)

Topics Discussed

Back on ADT, and now clobbered by fatigue — we suspect enzalutamide; exercise when walking’s too tough; he’s considering Pluvicto — but where’s the concordance scan?; FDG PET at low PSA?; when scanned, get the image CDs; new medonc OK’s ADT drug holiday at two years; more good reports on Dr. Bilusic; when dropping abi, taper prednisone cautiously; penile prosthesis surgery a success; insurance for yearly DEXA scans; urologists who don’t counsel on sexual dysfunction; making radiation a day at the beach; getting the word out on AnCan; hip issues and radiation; concerned about blood counts; shortness of breath and Flomax; drop abi, keep Lupron — or vice versa?; Peter K’s next move.

Chat Log

Alan Babcock · 7:21 PM
I have another meeting I have to attend. Hope to see everyone on Thursday.

Frank Fabish Columbus OH · 7:29 PM
has any read any information about the test trial of Anvirzel?

AnCan – rick · 7:35 PM
I know nothing about Anvirzel – but hopefully the Brains Trust can follow up

Frank Fabish Columbus OH · 7:37 PM
right. I think it is in Phase 1. not sure about PC trial. Hope to find out more info.

Julian – Houston · 7:45 PM
Phase 1 trial of Anvirzel™ in patients with refractory solid tumors, https://link.springer.com/article/10.1007/s10637-006-7772-x

Frank Fabish Columbus OH · 7:57 PM
TY

Len Sierra · 8:02 PM
For Frank Fabish: Anvirzel is a brand name for an aqueous extract of the plant Nerium oleander. Anvirzel contains two toxic cardiac glycosides, oleandrin and oleandrigenin. oleander is likely unsafe to take by mouth. It can cause a burning sensation in the mouth, nausea, vomiting, diarrhea, weakness, headache, stomach pain, serious heart problems, and many other side effects. Taking the oleander leaf, oleander leaf tea, or oleander seeds has led to deadly poisoning.

Frank Fabish Columbus OH · 8:03 PM
so I read about the extract

Frank Fabish Columbus OH · 8:14 PM
a friend of mine who had stage 4 metastatic PC with lesions on the brain. a brain bleed killed him Sunday. he was approved for this drug.