Low/Intermediate PCa Video Chat, November 24, 2025

by | Nov 26, 2025 | Cancer Caregivers, Cancer Resources, Low/Intermediate Prostate Cancer, Recorded Groups

Low/Intermediate PCa

Low/Intermediate PCa Video Chat, November 24, 2025

Low/Intermediate PCa Video Chat, November 24, 2025

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, Blue Earth Diagnostics, and Foundation Medicine.

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Editor’s Pick: Manage “buyer’s remorse” by trusting the decision. (bj)

Topics Discussed
Before treatment (cryotherapy/radiation), get a second pathology opinion (e.g., Dr. Epstein/Dr. Zhou) to confirm Gleason scores; high Decipher scores (e.g., 87) with favorable pathology (Gleason 3+4) may not necessitate leaving Active Surveillance; consult Centers of Excellence. Verify facility accreditation (NCI/NCCN “Centers of Excellence”); manage “buyer’s remorse” by trusting the decision (e.g., MRI-guided SBRT over surgery); weigh recurrence risks of focal versus whole-gland treatment; assess if a PSMA PET scan is necessary for localized intermediate-risk disease; review data on Androgen Deprivation Therapy (ADT) with radiation; consider short-term ADT (6 months) only for multiple intermediate risk factors; consider radiation (SBRT) with whole pelvic coverage over surgery for suspected extra-prostatic disease (lymph nodes) to avoid salvage radiation; use a low Decipher score (e.g., 0.26) to support foregoing ADT with radiation for intermediate-risk cancer.

Chat

AnCan – Stuart sent a chat · 7:58 PM
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881

AnCan – Stuart sent a chat · 7:59 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/  Tel:516-760-2037    jepstein@imppllc.com

AnCan–John A sent a chat · 8:41 PM
I am grateful to Howie for the term “sixes over sevens”.   I am going to create a new Gleason system using poker terms.

AnCan Bill  sent a chat · 8:42 PM
Well, I wouldn’t want a full house!

AnCan – rick sent a chat · 8:44 PM
McClure at Weill

AnCan – rick sent a chat · 8:46 PM
Vince Laudone and James Eastham at MSKCC

AnCan–John A sent a chat · 8:47 PM
Howie if you want I’ll read your complete Decipher report including GRID report

Mark Erickson sent a chat · 8:57 PM
can you please repeat how to tell if a group is a center of excellence

Larry (Alaska) sent a chat · 8:59 PM
There are 33 NCCN “Centers of Excellence” scattered across the country.

Larry (Alaska) sent a chat · 8:59 PM
https://www.nccn.org/home/member-institutions

AnCan–John A sent a chat · 8:59 PM
The accrediting groups are the NCCN National Comprehensive Cancer Network, or NCI National Cancer Institute.  Go to the website and navigate to Centers of Excellence

AnCan–John A sent a chat · 9:00 PM
thx Larry

AnCan – rick sent a chat · 9:00 PM
877 582 7011

David in Portland, OR sent a chat · 9:01 PM
One picture=1,000 words. This map shows the location of all the NCCN member institutions: https://www.nccn.org/home/member-institutions/

AnCan – rick sent a chat · 9:02 PM
NCI Centers link http://www.cancer.gov/research/nci-role/cancer-centers/find

AnCan Bill  sent a chat · 9:02 PM
Thank you Larry

Mark Erickson sent a chat · 9:02 PM
Thanks all

Larry (Alaska) sent a chat · 9:10 PM
I am a master or buyer’s remorse, seller’s remorse, second guessing and hindsight.  But one makes a decision based on the best information you have and do not hesitate, dither or delay.

Ancan – Boykin sent a chat · 9:13 PM
Recognize that any treatment has consequences. Decide what you can live with. In the end, it’s a personal decision

Jim Stewart Reno, NV sent a chat · 9:22 PM
Have to sign off, Happy Thanksgiving everyone!!!!

Ancan – Boykin sent a chat · 9:23 PM
Happy Thanksgiving Jim!

AnCan Bill  sent a chat · 9:23 PM
Take care Jim.

Bill (VA) sent a chat · 9:30 PM
First meeting I have understood what the focal/nano knife concern is on recurrence.

AnCan – rick sent a chat · 9:34 PM
Optimal Duration of Androgen Deprivation Therapy With Definitive Radiotherapy for Localized Prostate Cancer. https://ancan.us14.list-manage.com/track/click?u=ece3f3da90f82cb974b407396&id=06c8899f70&e=838454d636

AnCan – rick sent a chat · 9:35 PM
JAMA https://jamanetwork.com/journals/jamaoncology/fullarticle/2841671?guestAccessKey=d03b0908-90c8-497e-85cd-aebb43ec2a63&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jamaoncology&utm_content=olf-tfl_&utm_term=112025&mc_cid=0fa42784f6&mc_eid=838454d636

Mark Erickson sent a chat · 9:39 PM
Thanks everyone, Happy Thanksgiving

Ancan – Boykin sent a chat · 9:39 PM
Good Night Mark!

Larry (Alaska) sent a chat · 9:41 PM
Marc, it is a choice (in my mind) between 1) hit it hard and fast with risk of side effects or hit it minimally with s higher risk of recurrence

AnCan–John A sent a chat · 9:41 PM
‘night guys

David in Portland, OR sent a chat · 9:41 PM
Trip Trial compared six months to 30 months of ADT in randomized high risk patients who underwent beam plus brachy. It found no difference in outcomes. The incidence of biochemical recurrence rate at 7 years was 9%: https://www.redjournal.org/article/S0360-3016(23)07843-4/abstract

Bruce Schrimpf sent a chat · 9:56 PM
Great seeing and hearing from all of you!  I plan on being with the high-risk group tomorrow.  I will have an update tomorrow as I have recently returned from Mayo at Rochester.

Ancan – Boykin sent a chat · 9:57 PM
Good night Bruce!

AnCan – Stuart sent a chat · 10:05 PM
https://www.mskcc.org/nomograms/prostate

Tom O NJ sent a chat · 10:11 PM
Happy Thanksgiving All !!