Hi-Risk/Recurrent/Advanced PrCa Video Chat, Aug 26, 2025
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Editor’s Pick: Bright hopes for estradiol patches to reduce ADT effects, from Dr. Paul. (bn)
Topics Discussed
A professor’s worry about hot flashes while teaching prompts many familiar suggestions — plus an unexpected one: an illuminating discussion of estradiol by Dr. Paul, who’s serious about seeing it get wider use; Marc V., starting chemo, shares a “week that’s been one of the most challenging in my life”; PSA relapse after April’s Pluvicto leaves him wondering — more Pluvicto? xaluritamig trial? alpha trial?; wrestllng with Orgovyx side effects — on top of severe back pain, sleep apnea, and multiple sclerosis — and he’s seeing the wrong cancer specialist; new research of muscle loss in cancer; muscle loss hits a patient in his 80s harder than one in his 60s; why get two DNA tests — germline and somatic — for his RB1 gene?; he’s wondering what to expect when starting ADT — and while experiences vary, nobody here is a fan.
Chat Log
Jon McPhee Toronto · 6:26 PM
What about estrogen patches?
AnCan – rick · 6:26 PM
soy isoflavones
John A · 6:27 PM
Jon, yes that’s partly what I meant by if simple measures don’t work consider hormone treatment.
John Maxwell · 6:29 PM
HOT FLASHES: I am having good success with the Embr Wave 2 wrist band reducing, not eliminating my hot flashes, especially at night. I am very happy with it.
Alain · 6:30 PM
Thanks John!
Frank Ciambra · 6:52 PM
Xalurtamig
Len Sierra · 7:15 PM
www.mskcc.org
Charles James Ryan, MD – MSK Genitourinary Medical Oncologist
480 Red Hill Rd, Middletown, NJ 07748
Len Sierra · 7:18 PM
Phone for Ryan: Call 646-392-1746
AnCan – rick · 7:23 PM
Activin-A , Think the researcher may be David Hyman at MSKCC
AnCan – rick · 7:24 PM
first-in-human phase I study of the Activin A inhibitor, STM 434, in various solid tumors.
AnCan – rick · 7:44 PM
Jim C – Chuck Ryan’s URL https://www.mskcc.org/cancer-care/doctors/charles-ryan
AnCan – rick · 7:45 PM
dr.john@ancan.org
Jeff Marchi – San Francisco · 7:46 PM
A really good study by Dr. Efstathiou
Jon McPhee Toronto · 7:48 PM
Question: I am going to get a shot of Zoladex (goserelin). Apparently popular in Canada, but I never see it mentioned in US. Any idea why?
AnCan – rick · 7:50 PM
Frank C – alphabreak trial https://clinicaltrials.gov/study/NCT06402331?cond=Prostate%20Cancer&term=AlphaBreak&rank=1#locations
AnCan – rick · 7:52 PM
Frank C – in the middle of the country Grand Rapids, St. Louis, and Omaha offer the treatment.
AnCan – rick · 7:53 PM
Not great input on AMG509 – coupleof our guys could not get into th tril. One gent had no response.
Jeff Marchi – San Francisco · 7:53 PM
On ADT for 9 years. Orgovyx for 2 years. No real fatigue. It varies for others
Frank Ciambra · 7:54 PM
Thank you ,how can i get in touch with you
AnCan – rick · 7:59 PM
AMG509 – https://clinicaltrials.gov/study/NCT06402331?cond=Prostate%20Cancer&term=AlphaBreak&rank=1#locations
dan, alexandria · 8:00 PM
thanks