Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

NOTE: August Schedule Change for Tuesday meetings only – Tuesday, Aug 1 and 15

UPCOMING WEBINAR: What’s Inside the Black Box? -How & Why PCa Genomic Tests Work Register at https://tinyurl.com/ancanpcagenwebinar

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/      Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/                      Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s pick: Bones to boners in a little under two hours. (bn)

Topics discussed

A skeleton key to bone strengtheners, plus recommendations on calcium supplements; fracture adds to blood concerns; DLL3 as the PSMA for neuroendocrine PCa; apalutamide might not be a Tweedledee; hot flashes arrive after Firmagon has left the party; you can’t split a quarterback; delayed dose opens chasm of indecision; haze to hunger to relief then back to haze — is it ADT?; penile injections move the needle (not painful, sex great); long or short ADT after salvage; we run an ED joke up the flagpole as a grizzly bear reminiscence escapes.

Chat log

Julian – Houston · 6:56 PM
Have to leave early today. Thanks!

Steve Roux – Elk Rapids, MI · 7:38 PM
Gotta Run – new rescue puppy needs my attention. Great meeting! Thanks for all the info!

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 17, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 17, 2023

AnCan is grateful to the following sponsors for making this recording possible:  Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

NOTE: August Schedule Change for Tuesday meetings only – Tuesday, Aug 1 and 15

UPCOMING WEBINAR: What’s Inside the Black Box? -How & Why PCa Genomic Tests Work Register at https://tinyurl.com/ancanpcagenwebinar

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/      Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/                      Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: Worth waiting until the end to hear our sonorous tones on the Eastern Front relate liver marker issues during Pluvicto… but maybe down to gabapentin?? (rd)

Topics Discussed

New sponsor Blue Earth and Posluma; younger man (55) reports successful treatment; denovo Mx gent needs GU med onc; drug financial subsidies help- one of our gents; hypertension and abiraterone; neurological symptoms; lodging suggestions during treatment; cancer returns to prostate bed; 2nd series of Pluvicto treatments; what to do when PSA makes tiny move off insignificant; ALT & AST swing during Pluvicto – could it be an unrelated drug?; gabapentin issues

Chat Log

AnCan – rick sent · 5:34 PM Dr. Andrea Harzstark

AnCan – rick sent · 5:38 PM rd@ancan.org

Jim Marshall, Alexandria, VA sent · 5:59 PM Zytiga is also called Abiraterone It is generic.

Jim Marshall, Alexandria, VA sent · 6:03 PM Genitourinary Medical Oncologist

AnCan – rick sent · 6:13 PM Elisabeth Heath MD https://www.karmanos.org/karmanos/karmanos-physician-directory/heath-elisabeth-8225

AnCan – rick sent · 6:14 PM Karmanos

Rich Jackson sent · 6:19 PM Zytiga is also called Abiraterone It is generic.

Julian – Houston sent · 6:24 PM https://ancan.org/

sent · 6:29 PM No I am not a veteran.

Julian – Houston sent · 6:30 PM Dr. E is awesome!!!

AnCan – rick sent · 6:39 PM Who in Houston would talk to me about where to stay when going to MD Anderson. Can you say?

Matt Krieger sent · 6:41 PM What is pluvecto (spelling?)?

Peter Kafka – Maui sent · 6:41 PM Most centers have a sheet with places to stay that work with the hospital. Call your doc’s receptionist

AnCan – rick sent · 6:42 PM Pluvicto

Joe Gallo – Bucks Cty PA sent · 6:45 PM One of our AS moderators Hugh Idstein is a Houston resident if you want any help beyond the hospital list.

Richard Tolbert sent · 6:47 PM I live in the Houston area and can provide some hotel options near M.D. Anderson. (contact rd@ancan.org for Richard’s email)

AnCan – rick sent · 6:48 PM Another question to me from John Babb: As a disabled veteran which base or post would the best to try for housing while I am at MD Anderson?

Matt Krieger sent · 6:49 PM I nap every day at 55 if I can find a way!!

Don Needham – Bend, Or sent · 6:50 PM I nap every day after my walk and weights.

Julian – Houston sent · 6:50 PM Naps are good – I try to take one every mid-afternoon.

Matt Krieger sent · 6:58 PM It seems like everyone here is having PSA tests that have a sensitivity down to like .01, whereas the Kaiser tests I get just say ‘less than .06’ if it’s below that level. Should I be pushing for a more sensitive test, does that have value?

Peter Kafka – Maui sent · 7:00 PM You can try asking Kaiser about ultra sensitive PSA testing. But usually they only use it for guys who have had a prostatectomy as primary rather than radiation,

AnCan – rick sent · 7:01 PM Matt – My suggestion would be not to worry. You still have a prostate. I agree with Peter – not needed if you have a prostate.

Matt Krieger sent · 7:01 PM Got it, makes sense and thanks much —

Jim Marshall, Alexandria, VA sent · 7:02 PM Am using Kaiser and I get the Ultra-Sensitive every month for last year Mid Atlantic Kaiser

Frank Fabish Columbus OH sent · 7:06 PM Got to guys. Thanks guys. Stay strong.

Richard Tolbert sent · 7:07 PM Thanks everyone. Have a great week!

Matt Krieger sent · 7:12 PM I heard it too

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 11, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 11, 2023

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

NOTE: August Schedule Change for Tuesday meeting only – Tuesday, Aug 1 and 15

UPCOMING WEBINAR: What’s Inside the Black Box? -How & Why PCa Genomic Tests Work    Register at https://tinyurl.com/ancanpcagenwebinar

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime!   You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/      Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: Abiraterone can have significant cardio comorbidities (rd)

Topics discussed

Immediate recurrence following RP; older Gent seeks GU med onc after 12 years; PSA fluctuates during Pluvicto; no more Pluvicto problems – maybe thanks to AnCan!; GU med onc in Toronto – but is it needed?; abi +meddling with dosage may have lead to heart issues; older Gent continue Pluvicto; HT therapy does what it should – to the concern of this physician patient; doc raises darolutamide monotherapy; upcoming webinar and August calendar change

Chat Log

Neil Brandom sent · 3:23 PM Note to self : GU Medical oncologist  Mathew Rettic UCLA Rana McKay UCSD

AnCan – rick sent · 4:12 PM Michael Ong  http://www.med.uottawa.ca/internalmedicine/medical%20oncology/eng/MichaelOng.html

AnCan – rick sent · 4:19 PM Neil Fleshner https://www.uhn.ca/PatientsFamilies/Search_Doctors/Pages/doctor_detail.aspx?doctor=366

Len Sierra sent · 4:59 PM Jack et al., This is why you want to take darolutamide even with a low T level: Nubeqa (darolutamide) is an androgen receptor inhibitor. Darolutamide competitively inhibits androgen binding, AR nuclear translocation, and AR-mediated transcription

Alan Babcock sent · 5:02 PM That makes my wife happy. bye

Solo Arts Heal with Dan Baron

Solo Arts Heal with Dan Baron

AnCan and The Marsh (well renown, long-established theater company with a large following in the Bay Area and venues in San Francisco and Oakland) collaborate every 4th Wednesday of the month for Solo Arts Heal!

We are back with Solo Arts Heal, after a month off. Welcome June’s guest, Dan Baron!

Dan has been writing about social issues that impact people in underserved communities for more than 30 years. He writes content, grant proposals, and strategic communication plans for nonprofits, universities, and public agencies. He has also worked as a journalist. His work has mostly been about listening to the stories people tell about their lives as they advocate for better schools, safer communities, jobs, health care, and many other issues—including their basic human right to just be who they are. 

Wait a minute… or more… Dan also realized long ago that he has many personal stories to tell, just like everyone else on the planet. He tells his life-changing story about being a 21-year-old college student overseas who suddenly has a manic episode. Dan is part of a growing community where people share stories that aim to be poignant, funny, bizarre, challenging, and real. 

Dan shared his totally unexpected, way-up, way-down, bipolar experience as a college student in the 1980s—and how he has navigated his mental health journey since.

 

Watch here:

 

DMV AnCan’rs Break Bread!

DMV AnCan’rs Break Bread!

DMV AnCan’rs Break Bread!

You’ve heard me say it before and it never gets old… nothing gives me more pleasure than AnCan participants getting together outside our groups to meet and greet.

When a new participant in our High Risk/Recurrent/Advanced Prostate Cancer Group revealed recently he was from N. Virginia, not only was he well received by fellow locals but the cry went up for all to meet for lunch before too long. Capt. Jim Marshall led the charge by arranging a lunch in Alexandria at the end of June. I’ll let him tell you more ….

On Friday, June 30th, the DMV (District of Columbia/ Maryland/ Virginia) Brotherhood of AnCan’s High Risk/ Recurrent/ Advanced Prostate Cancer Virtual Group got together for a luncheon here in Alexandria, VA. We met at the Historic “Table Talk” Diner founded in 1976 that has changed little even in the age of rising property values and upscaling everything. On the first row of the photo L-R, is Joel Blanchette, Gary Peters and then standing L-R, myself Jim Marshall, George Rovder, Jimmy Greenfield, Cliff Collins and Richard Cramond.

It was a great opportunity to compare notes on our life situations and treatments but more important to get to know each other. It turns out I learned General Joel actually jumped out of airplanes in the younger days of his military career. Gary is a retired Federal Lawyer. George worked at the US State Dept. George’s husband is a Canadian and they are heading off camping over the 4th . Jimmy G, as we all know, is into music, can work up a real sweat (exercise) when his (new) band one gets going. In his younger days Jimmy was a full-time music teacher for kids and loved it – he still teaches young and old alike. Cliff was a Professor in the Air Force and regularly does 65-mile bike rides. Richard and I worked in close proximity in the 1970s in the forerunner of Space Force; satellites and things. As far as me, I can be found trimming a Peach Tree and also doing my daily 2-3-mile bike rides; consider I have a 15-year head start on Cliff.

We are looking forward to making this a recurring meeting during the year.

Jim Marshall

If any other AnCan’rs in any of our groups want to organize a ‘meet and greet’, please let us know and we’ll help with the contact information …. MSrs in Michigan???

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 3, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 3, 2023

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.

AnCan’s Prostate Cancer Forum is back https://ancan.org/forums. If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/    Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/      Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: This meeting was packed with lots of good stuff – from diabetes management on HT to the equivalency of gentle vs strenuous exercise (rd)

Topics discussed

Hormone treatment and diabetes management (see Chat); next ‘foamy gland’ treatment discussion; do I need a bone strengthener – pros & cons; does TP53 increase risk for other cancers?*; can ADT result in physical anxiety?; advanced prostate cancer management at Walter Reade Military Hospital; are scans a valid protocol to close out hormone therapy treatment?; is gentle vs strenuous exercise equivalent? * My lack of concern over TP53 is based on somatic mutations only! Germline TP53 carries risk for other cancers. (rd)

Chat Log

Ben Nathanson sent · 5:16 PM I think Jeff Marchi is right about the new video…we finally appear to have more than 25 cameras on!

Jim Marshall, Alexandria, VA sent · 5:18 PM It appears I can get up to 30 screens of people. jim Sylvester sent · 5:19 PM Sylvester has nothing tonight. I can hear this session. Thanks.

sent · 5:21 PM I can only get 8 active cameras. People go blank including me, and the 8 rotate between many people. If I pick everyone all but 8 cameras are blank, but I see 28 boxes If more than 28 here, it is now possible to slide over and see another screen of 28. That’s new

Larry Fish sent · 5:31 PM newer diabetes medications: I am on Mounjaro very effective AIC down from 8.1 to 7.1 in just 2 months; other more popular medication is Ozempic (sp?)

Steve Schuler sent · 5:53 PM Bye, have a safe 4th folks!

David Muslin sent · 6:14 PM What was that the name of the drug that Len just mentioned?

AnCan – rick sent · 6:15 PM Zometa

John A sent · 6:25 PM sorry pl defer to Dr Jack. Yes to PT and relaxation techniques. Yes to therapy for underlying fear. Can’t eliminate the cause–ADT and PCa.

David Muslin sent · 6:35 PM For what it’s worth, my Rad Onc at Northwestern stayed in touch with me for 12 months after my SBRT treatment

sent · 6:40 PM My Rad Onc is ordering a PSMA Pet scan. My Med Onc is ordering my meds.

AnCan – rick sent · 6:42 PM You need a GU med onc, Jay!

John A sent · 6:49 PM I tried that on my doc, and he was one of the authors of ARCHES. He declined to order any scans until my PSA got at least to .2.

Neil Sundstrom sent · 6:51 PM can you put that scan name in the chat?

george rovder arlington va sent · 6:52 PM https://peterattiamd.com/rajpaulattariwala/ Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology

Len Sierra sent · 6:55 PM Gentle exercise vs. strenuous exercise in cancer relate fatigue: https://journals.sagepub.com/doi/full/10.1177/15347354231162584

Ben Nathanson sent · 6:56 PM https://responding.substack.com/p/treading-softly

sent · 6:59 PM Diffusion weighted MRI. Dr. Raipaul Attariwala in Vancouver at AIM medical imaging

Frank Fabish Columbus OH sent · 7:01 PM Have a great 4th. See you next week.

Stan Friedman sent · 7:05 PM Len, are you on a beta blocker? I was experiencing real shortness of breadth a month ago and went to my internist. I had been taking propranolol for years to calm an essential tremor I had. He took my off the beta blocker and my short windedness disappeared and my fatigue lessened as well. Of course, my tremor is back, but I can deal with that.

Neil Sundstrom sent · 7:06 PM Gotta go. Happy 4th everyone.

David Muslin sent · 7:10 PM I have to roll gents. Have a safe 4th. Enjoy your families and be in the moment.

Cliff Collins sent · 7:11 PM I really must get some rest. I have a big bike ride in the morning. Please enjoy the 4th with family and friends.

Dennis Correia sent · 7:11 PM great discussion on exercise.

Webinar: PARP-Inhibitors and Prostate Cancer – Gotta Have a Mutation???

Webinar: PARP-Inhibitors and Prostate Cancer – Gotta Have a Mutation???

Parp-Inhibitors have long been on AnCan’s radar since our dear departed Boardie, Dr. Bill Burhans, found himself with olaparib in his lab in 2015 and convinced his tumor board to prescribe it along with abiraterone for his BRCA2 mutation.

Question is …

What’s a PARP-Inhibitor, and what does it do?

Who benefits from a PARP?

Do PARP-I’s work for everybody?

How can a PARP-I be used for prostate cancer?

AnCan brings you two experts to discuss. Dr. Pamela Munster of the UCSF BRCA Research Institute with her unique peer perspective, and Dr. Neal Shore who just released the TALAPRO-2 Study using a PARP with Xtandi.

 

Watch here:

 

 

Special thanks to Bayer, Pfizer, Myovant Sciences, Foundation Medicine, Myriad Genetics, Janssen – Johnson & Johnson, Telix, and Blue Earth Diagnostics for sponsoring this webinar.

 

 

For information on our peer-led video chat PROSTATE CANCER VIRTUAL SUPPORT GROUPS, click here.

To SIGN UP for any of our Virtual Support groups, visit our Contact Us page.

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 27, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 27, 2023

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

WEBINAR this week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at  https://tinyurl.com/ancanparpwebinar

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/  Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/         Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s pick: Where next when standard treatments are behind you? (bn)

Topics discussed

Chance a risky trial hundreds of miles away?; think ahead before firing the last bullet; mixed reviews of Cancer Commons; “too old for a PSA test” and now metastatic; what’s “Pluvicto” in Canadian?; one man, two dueling prostate cancers; making it through Pluvicto; check for PSMA avidity before a pricey treatment; will Pluvicto last?; facing chemo after six lucky years on ADT; after success with triplet therapy, time for drug holiday?; new man starting Keytruda; bad cancer + low PSA?; shrinking the unshrinkable prostate; turned away at OHSU and seeking something comparable; magnesium for neutropenia; BAT is no home run; what counts as exercise?

Chat Log

Mark Finn · 7:06 PM
Rick – finishing up packing for camping trip. Will have to depart soon.

David Muslin · 7:07 PM
Have fun Mark Finn

Ben Nathanson · 7:19 PM
Pluvicto – generic “lutetium Lu 177 vipivotide tetraxetan” – formerly “Lu-177 PSMA-617”

Frank Fabish Columbus OH · 7:32 PM
Got to go guys. Thanks again for good info. see you next Monday.

David Muslin · 7:48 PM
Got to roll men. See y’all next week.

AnCan – rick · 7:49 PM
646-749-3129 222 583 973

Steve Schuler · 7:49 PM
I think my laptop needs a reboot

Steve Schuler · 7:50 PM
My question was really simple actually: any suggestions in the northwest for good med oncologists for second opinions?

Bob G · 7:50 PM
Gotta go. Fatigue kicking in.

Steve Schuler · 7:51 PM
Yes, I’ve tried both the ear buds and now the laptop microphone, and neither is working for the microphone

Steve Schuler · 7:53 PM
Washington, Oregon, or I am also looking now at CA (San Francisco). I am willing to travel some. I am in Seattle

AnCan – rick · 7:53 PM
I’ll ask ….

Julian – Houston · 7:54 PM
Go to go – see you next week!

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 19, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 19, 2023

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

WEBINAR next week … PARP-Inhibitors and their role treating Prostate Cancer. Who saw the FDA approval for Talapro + Xtandi this week? Hear one of the investigators talk about this combo on Thu June 29. Register at   https://tinyurl.com/ancanparpwebinar

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/  Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/         Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s Pick: Hot flashes flare up! (rd)

Topics Discussed

Switching to darolutamide; is ARV7 still relevant?; cabazitaxel (Jevtana) vs docetaxel (Taxotere); mega fatigue may warrant a drug holiday; starting Pluvicto on top of chemo; Ambrx ARX517 trial; troublesome hot flashes are a flashpoint; picking the right GU med onc; starting immunotherapy while tapering on steroids; pectin supplements

Chat Log

Len Sierra sent · 5:28 PM Darolutamide inhibited the transcriptional activity of AR mutants identified in the plasma of CRPC patients progressing on traditional therapies. In particular, darolutamide significantly inhibited the transcriptional activity of the F877L, H875Y/T878A, F877L/T878A, and the previously unreported T878G AR mutants, that transform enzalutamide into a partial agonist.

John A sent · 5:33 PM Liu et al. Selective degradation of AR-V7 to overcome castration resistance of prostate cancer. Cell Death Dis. 2021

AnCan – rick sent · 5:38 PM Oliver Sartor now at Mayo

AnCan – rick sent · 5:49 PM Depo-Provera

George Southiere sent · 5:56 PM ACTH(adrenocorticotrphic) stimulation test = patient given ACTH and adrenal gland function is assessed- usually done by Endocrinologist

John A sent · 5:57 PM thanks

George Pat Martin sent · 6:00 PM I’m worn out. Gonna log off . be back next week

AnCan – rick sent · 6:04 PM Venlafaxine

Len Sierra sent · 6:05 PM https://embrlabs.com/products/embr-wave-2

AnCan – rick sent · 6:07 PM Embr watch.. d/c

Ancan50 sent · 6:07 PM Depo provera

George Southiere sent · 6:08 PM Gabapentin has helped me due to my severe neuropathy and has helped the hot flashes for me

sent · 6:09 PM I take 600mg gabapentin 3 times a day now. It never helped with my hot flashes.

Len Sierra sent · 6:37 PM modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

Len Sierra sent · 6:39 PM 1. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

Len Sierra sent · 6:40 PM https://pubmed.ncbi.nlm.nih.gov/14663471/

Salvador sent · 6:43 PM Thank You for your feedback.

Chip & Jane sent · 6:48 PM G’nite All.. thanks for the fine discussion.

George Rovder, Arlington VA sent · 6:52 PM Thank you all. Good Night.

Salvador sent · 6:53 PM Thank You everyone, I learned a lot tonight

Terrill SF sent · 6:53 PM Thank you all. Good Night.

Hi-Risk/Recurrent/Advanced PCa Video Chat, July 25, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 13, 2023

Hi-Risk/Recurrent/Advanced PCa Video Chat, June 13, 2023

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant & Telix

AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/
Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern
https://ancan.org/men-speaking-freely/
Veterans Healthcare… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/

Editor’s pick: Prostatectomy after 70. Also: Pluvicto wiped out 99% of his cancer — time for a jig! (bn)

Topics Discussed

Metformin’s faded glory in PCa treatment; grateful for heads-up on Xgeva with radium-223; statins and PCa — still anybody’s guess; darolutamide monotherapy might cut fatigue; curious about new hot-flash drug for women; experience with Onco360 pharmacy; when will white blood cells rebound from radiation; bike seats and PCa; seeing metastasis in lymph nodes that radiation skipped; dry mouth and depression overshadow wild Pluvicto success; too old for prostatectomy?; Keytruda and more Keytruda.

Chat Log

Steve in MI · 6:09 PM
Suttons Bay is nice; my wife has a few properties she manages up there. We get to Interlochen at least 2 or 3 times during the summer for concerts. Styx is the next one.

Steve in MI · 6:13 PM
There is a few up around here in the summer: Charlevoix, Fish Town, Elk Rapids. Ours is in August I think.

Julian – Houston · 6:18 PM
stopped taking because it made my bones ache!

Gary P · 6:20 PM
While not actually diabetic, I was put on Metformin after my blood sugar levels went up significantly on Abiraterone.

Julian – Houston · 6:24 PM
Same here, Gary. Took for awhile and my A1C came down.

AnCan – rick · 6:27 PM
Steve in MI …. check out this link https://pubmed.ncbi.nlm.nih.gov/?term=prostate+cancer%2C+statins

David Muslin · 6:36 PM
New hot flash drug just approved Fezolinetant aka Veozah

AnCan – rick · 6:38 PM
It was FDA approved on May 16… this is the one I read about

AnCan – rick · 6:39 PM
https://www.fda.gov/news-events/press-announcements/fda-approves-novel-drug-treat-moderate-severe-hot-flashes-caused-menopause#:~:text=Today%2C%20the%20U.S.%20Food%20and,hot%20flashes%2C%20caused%20by%20menopause.

Julian – Houston · 7:09 PM
Totally agree with exercising!!! It is necessary!

? · 7:12 PM
Agree. Hot flashes less severe or non-existent on days I walk 5 miles, so I go every day. Big motivator.

? · 7:22 PM
Jaynewman@cox.net

Dennis Correia · 7:26 PM
Try Biotene mouth rinse for dry mouth.

AnCan – rick · 7:31 PM
Pluvicto FDA approval https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pluvicto-metastatic-castration-resistant-prostate-cancer

AnCan – rick · 7:33 PM
“Patients received Pluvicto 7.4 GBq (200 mCi) every 6 weeks for up to a total of 6 doses plus BSoC or BSoC alone.”
BSoC = best standard of care

Tom Maloney · 7:34 PM
The recommended Pluvicto dose is 7.4 GBq (200 mCi) intravenously every 6 weeks for up to 6 doses, or until disease progression or unacceptable toxicity.

Tom Maloney · 7:34 PM
up to 6 doses, not requiring 6 doses.

AnCan – rick · 7:34 PM
The trials all gave 6 doses

Len Sierra · 7:36 PM
Tom, the dry mouth usually resolves by itself soon after your treatment is complete.

AnCan – rick · 7:38 PM
We do not know anyone who did less than 5 doses by choice. Doesn’t mean there aren’t any. However your doc is recommending you finish up.

AnCan – rick · 7:39 PM
We’ve seen less than 6 doses but only where blood counts or other markers have been compromised.

AnCan – rick · 7:45 PM
Xgeva = denosumab

Steve in MI · 7:52 PM
Keep coming back Spencer.

? · 7:52 PM
Thank you to everyone for excellent advise.

Joe (Dubois WY) · 7:59 PM
keytruda

Julian – Houston · 7:59 PM
Keytruda

Julian – Houston · 8:00 PM
Thanks guys. Another great session.

Joe (Dubois WY) · 8:04 PM
https://www.ouhealth.com/find-a-doctor/?Specialty=287086&Distance=5 Urologic Oncologists at OU in OKC

Joe (Dubois WY) · 8:05 PM
https://www.ouhealth.com/find-a-doctor/michael-s-cookson-md-mmhc/ this guy did a fleewship at MSK

Joe (Dubois WY) · 8:05 PM
fellowship

AnCan – rick · 8:05 PM
A urologic oncologist is a surgeon Joe. Not a med onc.

Joe (Dubois WY) · 8:05 PM
oh bummer

AnCan – rick · 8:06 PM
He needs a genitourinary medical oncologist

Joe (Dubois WY) · 8:06 PM
sure as hell standing in front a a Davinci