Hi-Risk/Recurrent/Advanced PCa Video Chat, April 8, 2025

by | Apr 13, 2025 | High Risk/Recurrent/Advanced, High Risk/Recurrent/Advanced Prostate Cancer, mCRPC, mHSPC, nmCRPC, Prostate Cancer, Recorded Groups

Intermediate Risk Prostate Cancer Graphic

Hi-Risk/Recurrent/Advanced PCa Video Chat, April 8, 2025

AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Novartis, Telix & Blue Earth Diagnostic.
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AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
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Complete Richard Wassersug’s E2/estradiol survey – open to all https://qualtricsxmxjhxcwlhx.qualtrics.com/jfe/form/SV_2h2GxUXB1lWMT9I

Editor’s Pick: Testosterone superman deflates — and his shrine is dismantled — after he checks his math (bn).

Topics Discussed

Will a switch to estrogen outsmart the cancer?; he was slated for 3 years of ADT, but may want to quit or or ease off on year 3 — many options exist but not all are proven; third Pluvicto round for Marc V — he’s looking well, and Dr. Aggarwal’s feeling good about the results; the right way to taper off a bone strengthener; the story of CD46, a promising PCa marker for theranostics; spotlight’s back on hot flashes — as usual, many suggestions; he wants to resume his job the day after brachy — possible?; cardio-oncologist in Chicagoland?; testosterone superman deflates — and his shrine is dismantled — after he checks his math; off ADT, should he worry about rising T?; too early in the game for neuroendocrine worries; even if you need to wait for a scan, don’t start ADT without one; don’t sweat the small stuff when it comes to rising PSA; insufficiency fractures; what to expect during radiation treatment — Dr. Mark’s the expert.

Chat Log

AnCan – rick · 6:41 PM
How Cancer Cells Travel to New Tissues and Take Hold… https://www.medscape.com/s/viewarticle/how-cancer-cells-travel-new-tissues-and-take-hold-2025a10007rt?ecd=WNL_trdalrt_pos1_250407_etid7346797&uac=529807HK&impID=7346797

AnCan – rick · 7:02 PM
Embr WAVE

Len Sierra · 7:02 PM

Embr Wave 2

Steve Roux, North Michigan · 7:09 PM
oxybutynin for hot flashes

david opp · 7:11 PM
I have had a urologist also recommend oxybutanin for ADT hot flashes

AnCan – rick · 7:11 PM
https://www.nejm.org/doi/full/10.1056/NEJMc1801992?query=TOC&

TonyFig · 7:15 PM
Neck fans are another option.

TonyFig · 7:16 PM
https://www.amazon.com/s?k=neck+fans+that+blow+cold+air&crid=3DRXO7F49TVE5&sprefix=neck+fan%2Caps%2C149&ref=nb_sb_ss_ts-doa-p_2_8

AnCan – rick · 7:24 PM
Here’s the Mayo paper by Brad Stish re. oxybutynin https://www.medpagetoday.com/meetingcoverage/asco/110457?xid=nl_mpt_DHE_2024-06-03&eun=g1169472d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%202024-06-03&utm_term=NL_Daily_DHE_dual-gmail-definition&mc_cid=81fa35ee19&mc_eid=838454d636&mc_cid=1550e5c67f&mc_eid=838454d636

AnCan – rick · 7:27 PM
Forget that link – here’s the right one https://www.medpagetoday.com/meetingcoverage/asco/110457?xid=nl_mpt_DHE_2024-06-03&eun=g1169472d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%202024-06-03&utm_term=NL_Daily_DHE_dual-gmail-definition&mc_cid=81fa35ee19&mc_eid=838454d636&mc_cid=1550e5c67f&mc_eid=838454d636

AnCan – rick · 7:30 PM
The culprit that makes oxyb. work better with abi is the CYP3A4

Steve Roux, North Michigan · 7:54 PM
I’m late for dinner. GREAT Mtg guys! See you next week!

John A · 8:14 PM
insufficiency fractures: result of normal stress on abnormal bone ….fatigue fx: abnormal stress on normal bone…. .pathological fx: diseased weakened bone due to tumors or abnormal bone . ….stress fx: means chronic mechanical stress exceeds the bone’s capacity

Bob Schwartz, USN, Venice FL · 8:15 PM
Another good mtg., have to go.

dan, alexandria · 8:15 PM
thanks all, have to go…