Hi-Risk/Recurrent/Advanced PrCa Video Chat, Nov 3, 2025

by | Nov 4, 2025 | High Risk/Recurrent/Advanced, High Risk/Recurrent/Advanced Prostate Cancer, mCRPC, mHSPC, Prostate Cancer, Recorded Groups, Uncategorized

Intermediate Risk Prostate Cancer Graphic

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Nov 3, 2025

AnCan thanks the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
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Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room

Editor’s Pick: High volume de novo metastatic diagnosis calls for triplet therapy.

Topics Discussed

Newbie with IDC-P (intraductal ) graduates from Low/Intermediate to High Risk Group; … and this Newbie goes the other way; last Newbie’s in the right group – denovo Mx & triplet Tx; wait on debulking treatment; 6 mo. doublet may not have been enough – discuss resumption w. Rettig; restart that prednisone ASAP; what to watch out for starting chemo – Neulasta, freeze packs et al; surgery removes cystitis tissue and finds no cancer

Chat (unabridged)

  •  

    AnCan – rick

    sent: 6:13 PM

    877 852 7011 GoTo help

  • Jim K

    sent: 6:18 PM

    Yes, my med onc suggested that I check out AUS bcz of my incontinence.

    I’d like to see if anyone in the group has had the artificial sphincter put in.

    I used to attend X (?) years ago, and stay in touch with Rick, and read the emails. I’ve been undetectable since June 2019, after a recurrence and radiation, after a Rad Pros in Aug 2017.

  • Jeff Marchi – San Francisco

    sent: 6:23 PM

    Jay from Miami raised his hand about intraductal

  • Jim K

    sent: 6:23 PM

    Thumbs up.

    No. Vietnam started to wind down by the time I hit 18, if I recall correctly.

  • AnCan–John A

    sent: 6:25 PM

    Jim K; So you have no mike but can hear us, right? I have had the AUS. —John A

  • Jim K

    sent: 6:25 PM

    Yes, no mic, but can hear the members.

  • Jim Marshall, Veteran, Alexandria, VA

    sent: 6:26 PM

    Think Jim K mike may work. Jim M

  • Jim K

    sent: 6:27 PM

    I’m using the browser, on Chrome, not the app, but it’s not enabling my mic. I’m on a Mac laptop.

    Yeah, no discernable improvement with Kegels. I use 7 or more pads per day. Just one at night. BUT, to keep my remaining kidney in good shape, I drink 96 oz of water per day, so, lots of peeing, understandably.

    Thanks, Larry, I’ll email you.

  • Steve R.

    sent: 6:30 PM

    A short video on Intraductal diagnosis and treatment from Urology Times https://www.urologytimes.com/view/dr-miron-on-the-treatment-of-intraductal-carcinoma-of-the-prostate

  • Len Sierra

    sent: 6:32 PM

    Steve R. reports this: Urology Times has a brief video on diagnosis and treatment of Intraductal. https://www.urologytimes.com/view/dr-miron-on-the-treatment-of-intraductal-carcinoma-of-the-prostate

  • Jeff Marchi – San Francisco

    sent: 6:38 PM

    https://www.prostatecancerpromise.org/?utm_campaign=ANCAN&utm_medium=link&utm_source=Webinar

  • AnCan–John A

    sent: 6:41 PM

    dr.john@ancan.org

  • AnCan – rick

    sent: 6:51 PM

    Dr. Sanoj Punnen https://sylvester-doctors.umiamihealth.org/provider/sanoj-punnen/525775

    Jim Marshall, Veteran, Alexandria, VA

    sent: 7:06 PM

    Will discuss it tomorrow night. Give Dr P my best. My PSA = 0.12 and I do not go back to her till it reaches PSA=0.8-1.0. Might be sometime next year. Jim

  • Frank Ciambra

    sent: 7:06 PM

    good night

  • Mark N

    sent: 7:12 PM

    Dr. John, I just sent you Dr. Epstein’s biopsy results. Thank you

  • Jeff Marchi – San Francisco

    sent: 7:12 PM

    Chicago Illinois Which one? At  U of Chicago  Russell Szmulewitz, MD – UChicago Medicine Or at Northwestern David J VanderWeele : Physician Profile: Robert H. Lurie Comprehensive Cancer Center of Northwestern University : Feinberg School of Medicine: Northwestern University

  • Jeff Marchi – San Francisco

    sent: 7:15 PM

    MSI (microsatellite instability) testing for prostate cancer is performed in specialized pathology laboratories using tissue samples obtained during a biopsy or surgery.

  • Len Sierra

    sent: 7:17 PM

    According to AI, Tumor Mutational Burden (TMB) can be measured in both solid tissue biopsy (tTMB) and liquid biopsy (bTMB

  • Steve R.

    sent: 7:18 PM

    Also per AI, MSI High can be detected by liquid biopsy https://pmc.ncbi.nlm.nih.gov/articles/PMC10098262/

  • Len Sierra

    sent: 7:20 PM

    Concordance between liquid TMB and tissue TMB can vary if tumor is not shedding into the blood.

  • Gary Martin

    sent: 7:23 PM

    Thank you very helpful information.

  • Jim Marshall, Veteran, Alexandria, VA

    sent: 7:30 PM

    I did 60 mionths of ADT + Abi and now am 39+ months into a Treatment Holiday. Jim Marshall

  • Jon McPhee Toronto

    sent: 7:31 PM

    What duration of doublet is recommended?

  • Jim Marshall, Veteran, Alexandria, VA

    sent: 7:32 PM

    Amount of time answer …. It Depends on many factors.

  • Bob Schwartz U.S.N. Venice, FL.

    sent: 7:35 PM

    Congrats Capt. Jim, 39+ months is GREAT!

  • Jim Marshall, Veteran, Alexandria, VA

    sent: 7:37 PM

    Eligard & Lupron is the exact same drug with a different method of delivery. Jim

  • Jim K

    sent: 7:40 PM

    I have to go, but am interested in AUS surgery. My email is: jimkubat@yahoo.com, if any of you have any time to chat about it. Larry, I’ll reach out. Thanks, Rick!!

  • AnCan – rick

    sent: 7:42 PM

    Orgovyx

  • Hank Zajic Springfield VA

    sent: 7:48 PM

    I have to go. Thank you everyone.

  • dan-s

    sent: 7:51 PM

    I have to go Gents… thanks for another great session

  • Gary Martin

    sent: 7:57 PM

    I asked about getting the anti-neutropenia meds and was told they did not plan on ordering those. My blood counts have not been extremely low and I seem to be tolerating docetaxel so far thru 5 infusion, though fatigue has been increasing.

  • Bruce Schrimpf

    sent: 7:59 PM

    Must run. Thanks for a great session! I will see Capt. Jim tomorrow.

  • Joe Comanda (Philadelphia)

    sent: 8:00 PM

    Need to take off. Will hold my question for another time.

  • Eric Curtis

    sent: 8:05 PM

    Gotta run. Appreciate the info

  • Gary Martin

    sent: 8:05 PM

    I’ve used cryotherapy (gloves and socks) circulating ice water with Polar Products equipment (available on Amazon) Use it 15 minutes before, during, and 15 minutes after infusion. So far, it’s working to avoid/minimize neuropathy. I also got the frozen gel gloves and socks as backup. It’s a hassle but I think wellworth the effort.

  • Thomas Matica

    sent: 8:08 PM

    Thanks, gents. Good night, sleep tight.