Editor’s Pick: Very rare penile metatstasis …. not to mention two younger men diagnosed, one denovo metastatic!
Happy Bastille Day ……. Topics Discussed
younger G9 man experiences recurrence; older man experiences recurrence; another younger denovo Mx man needs GU med onc on team; stock medicine cabinet before starting chemo; Neulasta patch falls off!; enzalutamide …. & bad dreams; let’s compare C11 with an Axumin scan; prepping for surgery and how to follow up; feeling mets grow in your penis!
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BARBARA DYSKANT (to Everyone): 3:09 PM: I will need to leave soon because Barry isn’t feeling well tonight. He will get another transfusion tomorrow (2 units this time) — help is on the way. I will stay in touch, of course. Have a great night.
AnCan – rick (to BARBARA DYSKANT): 3:13 PM: Got it B – feel free to come in and out!
BARBARA DYSKANT (Private): 3:13 PM: THanks Rick!!!! Have a great night.
Len (to Everyone): 3:15 PM: ancan.org
Len (to Everyone): 3:45 PM: From the TOPARP clinical trial: “Of these 16 patients, 14 (88%) had a response to olaparib, including all 7 patients with BRCA2 loss”
Madhav Mohan (to Everyone): 3:47 PM: Thanks Carl. can you repeat the name of the new drug you got on?
Madhav Mohan (to Everyone): 3:50 PM: my pre-surgery gleason was a 4/5.
Madhav Mohan (to Everyone): 3:51 PM: this was confirmed on the post surgery pathology – Primary was 4 and Secondary was 5
Madhav Mohan (to Everyone): 4:14 PM: Thanks Peter, Carl, Len, Rick. Real useful information. I checked my Genomic Assay – the mutations were in BRCA1, CDK12 which they called out and also mentioned NF1 and TERT
Len (to Everyone): 4:16 PM: The BRCA and CDK12 mutations are “actionable.” Not the others.
Madhav Mohan (to Everyone): 4:16 PM: Thats what they said, Len.
Madhav Mohan (to Everyone): 4:17 PM: :))
Carl Forman (Private): 4:29 PM: Curious about the new guy from last week who was told he has weeks to live, and was hopefully going to see Paul Corn. Have you heard from him since?
AnCan – rick (to Carl Forman): 4:32 PM: we set him up with Corn – this week I think
Gene Spesard (to Organizer(s) Only): 4:37 PM: Got to leave. Dog demands food.
AnCan – rick (to Everyone): 4:50 PM: PCa pamphlet http://urology.ucsf.edu/sites/urology.ucsf.edu/files/uploaded-files/attachments/localized_prostate_cancer_and_its_treatment_1.pdf
Nick (to Everyone): 4:59 PM: Thank you for all the valuable info and well wishes.
John A (to Everyone): 5:17 PM: “Prostate cancer with penile metastasis: a case report.” Hinyokika Kiyo 2005: 519(1);771-3. Sawada A, et al. Patient improved on Estramustine, Paclitaxel and Carboplatin.
Len (to Everyone): 5:19 PM: https://mpcproject.org/home
(Editor’s Note: What a meeting ….. 26 particpants with SIX (6) new men; 2 under 60 ….. in particular, catch John G and Doug M.)
Topics Discussed
8 months of treatment and docs say no more can be done!!; de novo penile metastasis; recurrent PCa in younger man; disease returns after 10 years!; de novo Mx Dx for scientist at NIH; HT side effects; atonic (non-contracting) bladder; intimacy references; weekly docetaxel regime; metformin recall
Chat Log
Len (to Everyone): 5:10 PM: www.ancan.org
Peter Kafka (to Organizer(s) Only): 5:22 PM: Micro Satelite Instability
Len (to Everyone): 5:29 PM: Genitourinary Oncologist
Peter Kafka (to Organizer(s) Only): 5:33 PM: Sir – Spheres for Liver Cancer mets
joed2: 5:34 PM: Microspheres for liver lesions
Jake Hannam (to Everyone): 5:38 PM: rd@ancan.org
Ancan – Rick (to Everyone): 6:12 PM: clinicaltrials.gov
Russ Smith (to Everyone): 6:34 PM: Under-60 Advanced Prostate Cancer July 9 @ 7:00 pm – 8:30 pm EDT |Recurring Event (See all) GoTo Meeting – Barniskis Room Back in mid-2012, the US Preventative Services Task Force first made the following recommendation with an associated D Grade: The U.S. Preventive Services Task Force (USPSTF) recommends against prostate-specific antigen (PSA)–based screening for prostate cancer. At the time, prostate cancer advocates objected strongly, warning it would result in many more men diagnosed de novo metastatic, and ultimately more disease specific deaths. Sadly, we have seen this manifested, especially with respect to younger men. AnCan clearly sees the trend along with a lack of support…
Ken Anderson (to Everyone): 6:36 PM: good post Russ….
John I (to Everyone): 6:47 PM: walter stadler is at U of Chicago–I saw russell szmulewitz at U of C & loved him bue insurancacemade me stop John I (to Everyone): 6:49 PM: alicia morgans https://www.nm.org/doctors/1417011529/alicia-k-morgans-md-mph
Russ Smith (to Everyone): 6:49 PM: Joe, email me at *******. I am from Chicago and on ADT, Lupron and Casodex, I use Trimix.
John I (to Everyone): 6:52 PM: Alicia Morgans’ telephone 312.695.0990 John I (to Everyone): 7:05 PM: Thanks MUCH for your hospitality everyone
Ken Anderson (to Everyone): 7:06 PM: thanks for stopping by……
New G4+4 Dx with very low PSA; Tx after Lu177 PSMA fails; immunotherapy with no positive markers vs Jevtana; perineal pain; successful RT to prostate for Mx man; remarkable continued success from abi; interpreting inconsistent scan report; recurrent PCa plateaus w/o treatment; continued success from PARP-I
Chat Log
Jake Hannam (to Everyone): 5:21 PM: Jonathan Epstein 410-955-5043
Len (to Everyone): 6:00 PM: Talabostat is an experimental drug that initiates an inflammatory response in the tumor microenvironment, converting cold tumors to hot tumors and thereby making them better targets for checkpoint inhibitors, like pembro or nivolumab. The open-label Phase 2 basket trial is NCT04171219
scott (to Everyone): 6:01 PM: I have to go. I have an online class tonight. Best to everyone. See you next meeting.
Larry Fish (to Everyone): 6:35 PM: there are a number of variations on the ‘perianal abscess leading to lumps and related painful cysts and common and unusual perianal conditions….you can just Google any of the related terms and get to the articles and links that I ran into in my intermittant condition and still looking for a definitive answer or treatment that relolves it permanently. So I use a ring pillow for my chair and it comes and goes.
Editor’s Pick: Why are there no new chemotherapy treatments for prostate cancer?
Topics Discussed
Using Procrit; docitaxel + carboplatin study; chemotherapy issues; bone density scans; itchy skin; cramping; chemo cycles vs rounds; pre-chemo advice; why no new chemo treatments?;genetic vs somatic gene testing; Covid19 impact on advanced treatment; scanning for recurrence – sensitivity; ROS1 mutation; liquid vs solid Bx analysis; are metastatic PCa cells homogenous; rectal pain post RT
Editor’s Pick: PRINT trial examines small cell/NE morphing … not to mention EXERCISE beats fatigue! (rd)
Topics Discussed
DeNovo Metastatic man enters trial for HPN424; yet more monotherapy bicalutamide – after 17 yrs of no treatment!; FMI finds ROS1 – what next; introducing palliative care; bone cancer pain or arthritis; PRINT trial looks to thwart PCa cells morphing to small cell/NE; clinical trials still shut down nationally; to radiate or not with 5 lesions?; Procrit?; another denovo Mx man asks should he do chemo?; EXERCISE WORKS to relieve fatigue from salvage RT!!!; remedies for hot sweats.
Rich Jackson (to Organizer(s) Only): 6:22 PM: About rhPSMA rhPSMA-7.3 (18F) consists of a radiohybrid Prostate-Specific Membrane Antigen (PSMA)-targeted receptor ligand which attaches to and is internalized by prostate cancer cells, and is labeled with the 18F radioisotope for PET imaging. Single intravenous administration of rhPSMA-7.3 (18F) for PET Scan
Dennis Correia (to Everyone): 6:32 PM: nct#02903160 (PRINT Trial)
Larry Fish (to Everyone): 7:05 PM: MMR mismatch repair deficiency
AnCan – Rick (to Everyone): 7:15 PM: https://www.urotoday.com/video-lectures/mcrpc-treatment/video/mediaitem/843-embedded-media2017-10-09-16-50-00.html?utm_source=newsletter_4869&utm_medium=email&utm_campaign=navigating-the-course-of-treatment-new-findings-meet-old-habits-findings-from-latitude
