Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 9, 2025
AnCan thanks the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Lotsa confusion throughout this week! To pick just one, Signatera MRD test.
Topics Discussed
Newbie has a great HCP team – but seeking more; Mayo bamboozles this Newbie – needs more and reliable information; another Newbie chose to leave himself on ADT for 5 years – and wonders about fatigue and weight gain he’s now shed w. GLP; muscle mass with low T; Regular finds Signatera MRD test – but it’s not yet FDA approved for prostate cancer… & Dr. Jack’s been following this test a long time; Epstein downgrades Gent from 4+5 to 4+3 – Kishan & MR Linac next; elevated liver enzymes after chemo; steady as he goes with 0.03 rise; what’s pituitary’s role for testosterone; PSA testing during Pluvicto
Chat
Alexander Lalov, Pendleton, IN
sent: 4:13 PM
Is the recording going to be made public?
Eric James; Tyler TX
sent: 4:13 PM
yes, on Youtube
AnCan – rick
sent: 4:14 PM
All our Recordings are posted on YuTube – over 700
Larry (Veteran, Alaskan)
sent: 4:16 PM
Check your camera shutter at the top of your screen
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881
Jay – those are the 2 pathologists for a 2nd opinion.
Alexander Lalov, Pendleton, IN
sent: 5:27 PM
Bary, would you post the web address, please
Alexander Lalov, Pendleton, IN
sent: 5:28 PM
Oh, Withing is the name. Thnx!
John G.
sent: 5:28 PM
https://www.youtube.com/watch?v=Ado6dItMebE Yes, even on androgen deprivation therapy (ADT) with testosterone suppressed to near-zero (castration levels), you can increase muscle mass and strength through resistance training, though gains are typically modest and focused on counteracting atrophy rather than dramatic hypertrophy.[1][3] ## Evidence from Studies Multiple clinical trials show prostate cancer patients on ADT gaining muscle mass and fiber size after 12–20 weeks of supervised resistance training, including compound lifts like squats and presses, performed 2–3 times weekly. Progressive overload—gradually increasing weights—prevents fiber size decline in both type I and II muscles and boosts capillarization for better performance. These adaptations occur via mechanical loading and protein synthesis pathways independent of testosterone, such as IGF-1 signaling.
Larry (Veteran, Alaskan)
sent: 5:28 PM
YMCA “Livestrong” program is designed for cancer survivors. Look it up
Larry (Veteran, Alaskan)
sent: 5:29 PM
Government funded, so it is free and includes YMCA membership for the 12 week duration,
Active Surveillance Prostate Cancer Video Chat, November 26th, 2025
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, and Blue Earth Diagnostics.
Active Surveillance (AS) for low-risk prostate cancer involves unique challenges compared to other treatments. This online support group is designed for men and their caregivers who are currently on or considering AS. We hold four meetings monthly, recording only the second and fourth sessions. Our discussions cover a wide range of topics, including anxiety management, biopsy experiences, and the decision-making process around continuing or discontinuing AS. Newcomers are given priority to share their experiences, so we encourage you to join us.
Chris L. (Windsor, CA)
Gut microbiome & phytochemical rich diet: YouTube: https://www.youtube.com/watch?v=0vR0QL3oR2k
Chris L. (Windsor, CA)
Asco highlights: https://www.urotoday.com/conference-highlights/asco-gu-2025/asco-gu-2025-prostate-cancer/158203-asco-gu-2025-gut-health-and-prostate-cancer-the-influence-of-a-specific-phytochemical-rich-food-capsule-plus-or-minus-a-probiotic-prebiotic-blend-on-symptoms-and-progression-a-randomised-double-blind-placebo-controlled-trial.html
Eric- Atlanta
https://howardwolinsky.substack.com/p/breaking-transperineal-biopsies-find?utm_source=publication-search
Bill Harris (Los Angeles)
Hi Rick. Hope all is well
Eric- Atlanta
Seminar link and info: https://aspatients.org/event/transperineal-vs-transrectal-biopsy-2025/
Eric- Atlanta
“Key Clinical Trials Driving the Debate Recent trials have brought new insights: Dr. Jim Hu (PREVENT, 2024): Zero infections with TP vs 1.4% with TR, suggesting a reduced risk of sepsis. Dr. Alastair Lamb and Dr. Richard Bryant (TRANSLATE, 2025): TP detected 5–6% more clinically significant cancers (Grade Group ≥ 2) and often required no antibiotics. Dr. Badar Mian (PRoBE-PC, 2024): Both methods proved safe and effective, giving patients more choice. Together, these studies have reshaped how experts think about prostate biopsy safety.”
Ray E Santa Monica Ca
https://www.perplexity.ai/search/262e8d77-95e5-4fef-aa07-9b7a313c25f1
Ray E Santa Monica Ca
Above is a run down on TP vs Transrectal biopsy
Bill (VA)
Walter Reed now performing TP
AnCan – rick
AnCan Prostate Cancer Debate Aug 2022 Dr. George vs Dr. Kaye https://ancan.org/webinar-prostate-cancer-biopsies-the-great-debate/
Bill Harris (Los Angeles)
Bill Harris wmharris@gmail.com
Bill Harris (Los Angeles)
(new inherited mutation group
Active Surveillance Prostate Cancer Video Chat, November 12th, 2025
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, and Blue Earth Diagnostics.
Active Surveillance (AS) for low-risk prostate cancer involves unique challenges compared to other treatments. This online support group is designed for men and their caregivers who are currently on or considering AS. We hold four meetings monthly, recording only the second and fourth sessions. Our discussions cover a wide range of topics, including anxiety management, biopsy experiences, and the decision-making process around continuing or discontinuing AS. Newcomers are given priority to share their experiences, so we encourage you to join us.
You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/. Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/.
Chat Log:
AnCan – rick
If you have any technical problems, call GoTo at 877 582 7011
AnCan – rick
Dr. Jonathan Epstein – https://advanceduropathology.com Tel: 516-760-2037 jepstein@imppllc.com
AnCan – rick
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881
Bill (VA)
You can be a “6” but that assumes it is all found.
AnCan – rick
Dr. Kristen Scarpato Vanderbilt https://www.vumc.org/urology/person/kristen-scarpato-md-mph
Dan Gifford, Pensacola, FL
Tapping out for the night. See you next week.
AnCan – rick
My bet is that Carroll would not recommend annual Bx for 3+3.
Hi-Risk/Recurrent/Advanced PrCa Video Chat, Nov 3, 2025
AnCan thanks the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: High volume de novo metastatic diagnosis calls for triplet therapy.
Topics Discussed
Newbie with IDC-P (intraductal ) graduates from Low/Intermediate to High Risk Group; … and this Newbie goes the other way; last Newbie’s in the right group – denovo Mx & triplet Tx; wait on debulking treatment; 6 mo. doublet may not have been enough – discuss resumption w. Rettig; restart that prednisone ASAP; what to watch out for starting chemo – Neulasta, freeze packs et al; surgery removes cystitis tissue and finds no cancer
Chat (unabridged)
AnCan – rick
sent: 6:13 PM
877 852 7011 GoTo help
Jim K
sent: 6:18 PM
Yes, my med onc suggested that I check out AUS bcz of my incontinence.
I’d like to see if anyone in the group has had the artificial sphincter put in.
I used to attend X (?) years ago, and stay in touch with Rick, and read the emails. I’ve been undetectable since June 2019, after a recurrence and radiation, after a Rad Pros in Aug 2017.
Jeff Marchi – San Francisco
sent: 6:23 PM
Jay from Miami raised his hand about intraductal
Jim K
sent: 6:23 PM
Thumbs up.
No. Vietnam started to wind down by the time I hit 18, if I recall correctly.
AnCan–John A
sent: 6:25 PM
Jim K; So you have no mike but can hear us, right? I have had the AUS. —John A
Jim K
sent: 6:25 PM
Yes, no mic, but can hear the members.
Jim Marshall, Veteran, Alexandria, VA
sent: 6:26 PM
Think Jim K mike may work. Jim M
Jim K
sent: 6:27 PM
I’m using the browser, on Chrome, not the app, but it’s not enabling my mic. I’m on a Mac laptop.
Yeah, no discernable improvement with Kegels. I use 7 or more pads per day. Just one at night. BUT, to keep my remaining kidney in good shape, I drink 96 oz of water per day, so, lots of peeing, understandably.
Thanks, Larry, I’ll email you.
Steve R.
sent: 6:30 PM
A short video on Intraductal diagnosis and treatment from Urology Times https://www.urologytimes.com/view/dr-miron-on-the-treatment-of-intraductal-carcinoma-of-the-prostate
Will discuss it tomorrow night. Give Dr P my best. My PSA = 0.12 and I do not go back to her till it reaches PSA=0.8-1.0. Might be sometime next year. Jim
Frank Ciambra
sent: 7:06 PM
good night
Mark N
sent: 7:12 PM
Dr. John, I just sent you Dr. Epstein’s biopsy results. Thank you
Jeff Marchi – San Francisco
sent: 7:12 PM
Chicago Illinois Which one? At U of Chicago Russell Szmulewitz, MD – UChicago Medicine Or at Northwestern David J VanderWeele : Physician Profile: Robert H. Lurie Comprehensive Cancer Center of Northwestern University : Feinberg School of Medicine: Northwestern University
Jeff Marchi – San Francisco
sent: 7:15 PM
MSI (microsatellite instability) testing for prostate cancer is performed in specialized pathology laboratories using tissue samples obtained during a biopsy or surgery.
Len Sierra
sent: 7:17 PM
According to AI, Tumor Mutational Burden (TMB) can be measured in both solid tissue biopsy (tTMB) and liquid biopsy (bTMB
Concordance between liquid TMB and tissue TMB can vary if tumor is not shedding into the blood.
Gary Martin
sent: 7:23 PM
Thank you very helpful information.
Jim Marshall, Veteran, Alexandria, VA
sent: 7:30 PM
I did 60 mionths of ADT + Abi and now am 39+ months into a Treatment Holiday. Jim Marshall
Jon McPhee Toronto
sent: 7:31 PM
What duration of doublet is recommended?
Jim Marshall, Veteran, Alexandria, VA
sent: 7:32 PM
Amount of time answer …. It Depends on many factors.
Bob Schwartz U.S.N. Venice, FL.
sent: 7:35 PM
Congrats Capt. Jim, 39+ months is GREAT!
Jim Marshall, Veteran, Alexandria, VA
sent: 7:37 PM
Eligard & Lupron is the exact same drug with a different method of delivery. Jim
Jim K
sent: 7:40 PM
I have to go, but am interested in AUS surgery. My email is: jimkubat@yahoo.com, if any of you have any time to chat about it. Larry, I’ll reach out. Thanks, Rick!!
AnCan – rick
sent: 7:42 PM
Orgovyx
Hank Zajic Springfield VA
sent: 7:48 PM
I have to go. Thank you everyone.
dan-s
sent: 7:51 PM
I have to go Gents… thanks for another great session
Gary Martin
sent: 7:57 PM
I asked about getting the anti-neutropenia meds and was told they did not plan on ordering those. My blood counts have not been extremely low and I seem to be tolerating docetaxel so far thru 5 infusion, though fatigue has been increasing.
Bruce Schrimpf
sent: 7:59 PM
Must run. Thanks for a great session! I will see Capt. Jim tomorrow.
Joe Comanda (Philadelphia)
sent: 8:00 PM
Need to take off. Will hold my question for another time.
Eric Curtis
sent: 8:05 PM
Gotta run. Appreciate the info
Gary Martin
sent: 8:05 PM
I’ve used cryotherapy (gloves and socks) circulating ice water with Polar Products equipment (available on Amazon) Use it 15 minutes before, during, and 15 minutes after infusion. So far, it’s working to avoid/minimize neuropathy. I also got the frozen gel gloves and socks as backup. It’s a hassle but I think wellworth the effort.
Active Surveillance Prostate Cancer Video Chat, October 22nd, 2025
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Myriad Genetics, Telix, and Blue Earth Diagnostics.
Active Surveillance (AS) for low-risk prostate cancer involves unique challenges compared to other treatments. This online support group is designed for men and their caregivers who are currently on or considering AS. We hold four meetings monthly, recording only the second and fourth sessions. Our discussions cover a wide range of topics, including anxiety management, biopsy experiences, and the decision-making process around continuing or discontinuing AS. Newcomers are given priority to share their experiences, so we encourage you to join us.
AnCan Bill
Jonathan I. Epstein Integrated Medical Professionals Pathology Advanced Uropathology of New York www.advanceduropathology.com jepstein@imppllc.com
AnCan Bill
Ming Zhou, MD, PHD, Ming.zhou@mountsinai.org
AnCan Bill
Have a good night guys. I have an early morning tomorrow. Take care.
Phil Segal- Toronto
Thanks Bill
AnCan – rick
Germline Study….. PROMISE https://www.prostatecancerpromise.org/?utm_campaign=ANCAN&utm_medium=link&utm_source=Webinar
AnCan – rick
MRI 2nd Opinions webinar ProstatID https://ancan.org/webinar-mri-2nd-opinions-prostatid-solves-the-challenge/
Wayne Greaves
Free MRI 2nd opinion at NIH/NCI. Peter Choyke – pchoyke@mail.nih.gov
