Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 9, 2025
AnCan thanks the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.
AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
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Join our other free and drop in groups:
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Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room
Editor’s Pick: Lotsa confusion throughout this week! To pick just one, Signatera MRD test.
Topics Discussed
Newbie has a great HCP team – but seeking more; Mayo bamboozles this Newbie – needs more and reliable information; another Newbie chose to leave himself on ADT for 5 years – and wonders about fatigue and weight gain he’s now shed w. GLP; muscle mass with low T; Regular finds Signatera MRD test – but it’s not yet FDA approved for prostate cancer… & Dr. Jack’s been following this test a long time; Epstein downgrades Gent from 4+5 to 4+3 – Kishan & MR Linac next; elevated liver enzymes after chemo; steady as he goes with 0.03 rise; what’s pituitary’s role for testosterone; PSA testing during Pluvicto
Chat
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Alexander Lalov, Pendleton, IN
sent: 4:13 PM
Is the recording going to be made public?
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Eric James; Tyler TX
sent: 4:13 PM
yes, on Youtube
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AnCan – rick
sent: 4:14 PM
All our Recordings are posted on YuTube – over 700
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Larry (Veteran, Alaskan)
sent: 4:16 PM
Check your camera shutter at the top of your screen
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AnCan – rick
sent: 4:19 PM
877 582 7011 GoTo
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Jeff Marchi – San Francisco
sent: 4:28 PM
free genetic testing PROMISE PCa Germline Project
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AnCan – rick
sent: 4:31 PM
Tx Jeff – Doug has germline already
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Jeff Marchi – San Francisco
sent: 4:32 PM
ok i hear you
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Alexander Lalov, Pendleton, IN
sent: 4:34 PM
As far as I know PROMISE do Hereditary Cancer Test Only.
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AnCan – rick
sent: 4:35 PM
Yes Promise is only germline
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AnCan – rick
sent: 4:35 PM
Gents – I have poor bandwidth today . There’s an interent issue here.
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AnCan – rick
sent: 4:47 PM
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Jim Marshall, Veteran, Alexandria, VA
sent: 4:59 PM
When you ask for the Promise test, do not specify any doctor. It is between you and Promise. Jim
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Jay in MN
sent: 5:10 PM
👍
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AnCan – rick
sent: 5:15 PM
Dr. Jonathan Epstein – https://advanceduropathology.com/ Tel: 516-760-2037 jepstein@imppllc.com
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AnCan – rick
sent: 5:16 PM
Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881
Jay – those are the 2 pathologists for a 2nd opinion.
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Alexander Lalov, Pendleton, IN
sent: 5:27 PM
Bary, would you post the web address, please
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Alexander Lalov, Pendleton, IN
sent: 5:28 PM
Oh, Withing is the name. Thnx!
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John G.
sent: 5:28 PM
https://www.youtube.com/watch?v=Ado6dItMebE Yes, even on androgen deprivation therapy (ADT) with testosterone suppressed to near-zero (castration levels), you can increase muscle mass and strength through resistance training, though gains are typically modest and focused on counteracting atrophy rather than dramatic hypertrophy.[1][3] ## Evidence from Studies Multiple clinical trials show prostate cancer patients on ADT gaining muscle mass and fiber size after 12–20 weeks of supervised resistance training, including compound lifts like squats and presses, performed 2–3 times weekly. Progressive overload—gradually increasing weights—prevents fiber size decline in both type I and II muscles and boosts capillarization for better performance. These adaptations occur via mechanical loading and protein synthesis pathways independent of testosterone, such as IGF-1 signaling.
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Larry (Veteran, Alaskan)
sent: 5:28 PM
YMCA “Livestrong” program is designed for cancer survivors. Look it up
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Larry (Veteran, Alaskan)
sent: 5:29 PM
Government funded, so it is free and includes YMCA membership for the 12 week duration,
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AnCan – rick
sent: 5:29 PM
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Eric James; Tyler TX
sent: 5:30 PM
Yes, muscle mass may be increased, if you haven’t already been doing resistance training.
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Larry (Veteran, Alaskan)
sent: 5:32 PM
Lupron has been demonstrated to cause weight gain. I am not sure about lymphedema, though.
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Larry (Veteran, Alaskan)
sent: 5:33 PM
Ask about going on an ADT “Vacation”. Stop the ADT and closely observe the PSA response.
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AnCan – rick
sent: 5:34 PM
rick rd@ancan.org dr. john dr.john@ancan.org
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Larry (Veteran, Alaskan)
sent: 5:34 PM
If you go on ADT vacation, do it with the supervision of your oncologist.
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AnCan – rick
sent: 5:35 PM
Larry – he needs to find a new oncologist
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Eric James; Tyler TX
sent: 5:49 PM
Did Dr. Epstein provide any other details? % 4 vs %3? Invasion, intraductal, etc.?
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AnCan – rick
sent: 5:56 PM
Check Prostox test’ also watch our Prostox webinar. https://ancan.org/event/special-presentation-what-if-you-could-predict-the-risk-of-radiation-effects-prostox-and-beyond/
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AnCan – rick
sent: 5:58 PM
RT machine is MR-Linac
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Steve Roux, North Michigan
sent: 6:07 PM
sorry guys – I need to bug out.