Patient Highlights from the 2024 ASCO GU conference
In a 75-minute “pre-game” before the 2/27/2024 meeting of the high-risk/recurrent/advanced prostate cancer group, moderators John, Rick, Ben, and Len discussed highlights from the just-concluded ASCO GU conference, a major meeting for genitourinary cancer specialists. They selected from hundreds of papers on prostate cancer presented in sessions and posters. We closed with a 30-minute audience Q&A.
What we covered:
Abi boosts olaparaib for BRCA
After triplet therapy, what next?
Less treatment, same cancer-fighting power
Trial of a neuroendocrine PCa drug
Prostate cancer and suicide
Germline & somatic testing is too infrequent
What treatments work after Pluvicto
Pluvicto flare largely lasts only one treatment
Community providers do poor job treating mCSPC men
Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 19, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
darolutamide achieves undetectable status after many years; should he radiate L4 – ask his QB!; PSMA scans at low PSA levels; intermittent hormone therapy requires active surveillance… and anxiety for some; Ac225 Tx in Austria followed by Ac225+Lu177 and a PARP with no HRR mutation; another Gent remains undetectable; no evidence of PCa from scans but inferior blood counts; Newbie at the back end – 20 year survivor finally requires 2nd line anti-androgen
Even though I have been on Treatment Holiday for 21 months I still get my PSA and testosterone blood test every month. I feel like I am then proactive. jim Marshall
Jerry Grimes, Brighton, MI
sent: 6:55 PM
Hey all, gotta run. All the best!
Peter Kafka – Maui
sent: 7:08 PM
With all this movement in the nuclear medicine field, are there specialized Nuclear Oncologists now working at Centers of Excellence or is much of this being managed by GU Med Oncs or Radiation Oncs?
Len Sierra
sent: 7:09 PM
Peter, in many instances, nuclear medicine specialists are used.
Len Sierra
sent: 7:19 PM
The European Medicines Agency (EMA) is the European Union’s (EU) equivalent to the FDA. The EMA is a decentralized agency located in Amsterdam, Netherlands, that evaluates, supervises, and monitors the safety of medicines for humans and animals in the EU and the European Economic Area (EEA). The FDA and the EMA work together to streamline efforts, share best practices, and promote human and animal health.
Len Sierra
sent: 7:40 PM
From Johns Hopkins: Blood cells are made in the bone marrow. The bone marrow is the soft, spongy material in the center of the bones. It produces about 95% of the body’s blood cells. Most of the adult body’s bone marrow is in the pelvic bones, breast bone, and the bones of the spine.
Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 13, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: A penile prosthesis, and a lot of new hips. (bn)
Topics Discussed
Back on ADT, and now clobbered by fatigue — we suspect enzalutamide; exercise when walking’s too tough; he’s considering Pluvicto — but where’s the concordance scan?; FDG PET at low PSA?; when scanned, get the image CDs; new medonc OK’s ADT drug holiday at two years; more good reports on Dr. Bilusic; when dropping abi, taper prednisone cautiously; penile prosthesis surgery a success; insurance for yearly DEXA scans; urologists who don’t counsel on sexual dysfunction; making radiation a day at the beach; getting the word out on AnCan; hip issues and radiation; concerned about blood counts; shortness of breath and Flomax; drop abi, keep Lupron — or vice versa?; Peter K’s next move.
Chat Log
Alan Babcock · 7:21 PM
I have another meeting I have to attend. Hope to see everyone on Thursday.
Frank Fabish Columbus OH · 7:29 PM
has any read any information about the test trial of Anvirzel?
AnCan – rick · 7:35 PM
I know nothing about Anvirzel – but hopefully the Brains Trust can follow up
Frank Fabish Columbus OH · 7:37 PM
right. I think it is in Phase 1. not sure about PC trial. Hope to find out more info.
Len Sierra · 8:02 PM
For Frank Fabish: Anvirzel is a brand name for an aqueous extract of the plant Nerium oleander. Anvirzel contains two toxic cardiac glycosides, oleandrin and oleandrigenin. oleander is likely unsafe to take by mouth. It can cause a burning sensation in the mouth, nausea, vomiting, diarrhea, weakness, headache, stomach pain, serious heart problems, and many other side effects. Taking the oleander leaf, oleander leaf tea, or oleander seeds has led to deadly poisoning.
Frank Fabish Columbus OH · 8:03 PM
so I read about the extract
Frank Fabish Columbus OH · 8:14 PM
a friend of mine who had stage 4 metastatic PC with lesions on the brain. a brain bleed killed him Sunday. he was approved for this drug.
Hi-Risk/Recurrent/Advanced PCa Video Chat, Jan 15, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
Welcome AnCan’s first 2024 webinar with two blockbuster headliners — GU med onc Dr. Oliver Sartor and nuclear medicine pioneer Dr. Phillip H. Kuo — “Radionuclide Diagnostics & Theranostics – Theory and Clinical Practice Meet!” Register now at https://tinyurl.com/radionuclide – free as always. Two globally recognized experts introduce us to radionuclide scans and treatment, and help us understand how best to coordinate our care team.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Four new men give us plenty to talk about. (bn)
Topics Discussed
With “innumerable” metastases, he braces for chemotherapy; urologist blames the patient for ADT mood swings, and also fails to prescribe second-line drug; focal therapy might be right for post-radiation recurrence; PSA nearly 50 but biopsy claims he’s Gleason 6 — prostatectomy proves otherwise; colon cancer’s genetic tie-in with prostate cancer; drug holiday’s an option, but keep calm when PSA creeps up; “I’ve been to the four corners of the United States” seeing doctors — Dr. E is next; don’t put off somatic testing, and consider abiraterone monotherapy; let precision medicine target your BRCA before considering a clinical trial; vomiting worsens with with each Pluvicto round — seek palliative care!; wobbly testosterone recovery; even without testosterone, getting stronger through exercise.
Chat Log
Peter Kafka – Maui · 8:23 PM
somatic genetic testing
AnCan – rick · 8:28 PM
Men Speaking Freely https://ancan.org/men-speaking-freely/ Thursday, 8.00 pm Eastern in this room. Just drop-in
AnCan – rick · 8:37 PM
Genitourinary Medical Oncologist
Peter Kafka – Maui · 8:39 PM
peterk@ancan.org
AnCan – rick · 8:46 PM
Channing Paller https://www.hopkinsmedicine.org/profiles/results/directory/profile/3138167/channing-paller
AnCan – rick · 8:50 PM
PROMISE https://www.prostatecancerpromise.org/?utm_campaign=ANCAN&utm_medium=link&utm_source=Webinar
AnCan – rick · 8:54 PM
Steven don’t forget Men Speaking Freely on Thursday
dennis NJ · 9:10 PM
Thank you everyone
AnCan – rick · 9:17 PM
Elisabeth Heath https://www.karmanos.org/karmanos/karmanos-physician-directory/heath-elisabeth-8225
Frank Fabish Columbus OH · 9:39 PM
Thanks everyone. got to go.
Gary – New Jersey · 9:41 PM
Thank you everyone for the discussion and your suggestions. Have to go now.
“Thomas” Matica WA · 9:52 PM
Thanks, Len. I’ll look it up.
Len Sierra · 9:54 PM
HK2 : Human kallikrein-related peptidase 2 (hK2) is a tumor-associated member of the kallikrein family that shares significant homology to prostate-specific antigen and is minimally expressed in normal non-prostate tissues.
Jeff betz · 10:02 PM
Gotta go guys thank you!
AnCan – rick · 10:08 PM
https://ancan.org/your-dental-health/ Dental Posts
Len Sierra · 10:12 PM
Phase 2 study suggests that Abi monotherapy may be as effective as Abi + ADT. Published in journal Nature. https://www.nature.com/articles/s41391-022-00533-6
Steven Roberts · 10:13 PM
ok, fellas I got to drop….talk to you all next week and thanks
Hi-Risk/Recurrent/Advanced PCa Video Chat, Jan 9, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
Welcome AnCan’s first 2024 webinar with two blockbuster headliners — GU med onc Dr. Oliver Sartor and nuclear medicine pioneer Dr. Phillip H. Kuo — “Radionuclide Diagnostics & Theranostics – Theory and Clinical Practice Meet!” Register now at https://tinyurl.com/radionuclide – free as always. Two globally recognized experts introduce us to radionuclide scans and treatment, and help us understand how best to coordinate our care team.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Three things that are slow to change — liver enzymes, testosterone, and hormone sensitivity. (bn)
Topics Discussed
Skip the Lupron and do 2nd-line monotherapy off the bat?; dealing with ADT via antidepressants; he’s looking down the road at Pluvicto; weighing two clinical trials — or none; great first encounter with Dr. Heath; hey, don’t you want to know the Gleason score?; what made his cancer mutations jump?; hold off Keytruda if there’s no MSI?; liver tests slow to recover after abi; stay calm restarting ADT after a drug holiday; back chasing ZZZs; a few zaps with X-rays, or many with protons?; sciatica probably wasn’t the Lupron shot; how quick a rebound after Lupron?; an unexpected test (CEA) from Dr. E; radiation cystitis 8 years out
Chat Log
Steve Roux, MI · 6:13 PM
I’m glad to hear that because I ordered that same one today!
