Hi-Risk/Recurrent/Advanced PrCa Video Chat, Aug 4, 2025

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Aug 4, 2025

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Editor’s Pick: Estradiol expert peers Schellhammer and Wassersug discuss ADT and use (rd)

Topics Discussed

ADT side effects and estradiol discussion; restarting monotherapy darolutamide; CT scans carry little secondary cancer risk; cancer is an aggressive variant that can’t be identified; lower back pain; starting ADT + RT for BCR; Ph. 3 AMG509 trial – xaluritamig STEAP T-cell engager; zoledronic acid (Zometa et al) vs denosumab (Xgeva et al); chemo side effects – overdosing steroids?; IDC-P (intraductal) Gent needs new doc; dialiing back IDC-P outlook a tad Chat Log

Chat Log

• Scott Romsos – Ely, NV sent: 5:14 PM

  It is all good Mr Nathanson, no worries.

• RJ Smith (Seattle)sent: 5:18 PM

  Hey Steve–so far, so good. Starting IMRT on Thursday (got my gold markers and then tatoos, so good to go). Dr. Meier is awesome, BTW. He isn’t doing my IMRT, but Dr Spiegel in Issaquah seems pretty good as well where that starts on Thurs, and then SBRT for “boost” as well as for rib met after that…. Also, when I got markers put in, they checked PSA, which is now down to 1.02 with the ADT, so definitely feeling I’m on the right path now.

• Jerry Grimes, Brighton, MI sent: 5:23 PM

  My bone density actually recovered to a normal range after I went on estradiol. I was on the verge of osteoporosis.

• Ben Nathanson sent: 5:38 PM

  John G — Having a list of exercises can help. “Exercise Recommendations for Prostate Cancer” from Fred Hutch: https://www.fredhutch.org/content/dam/www/research/institute-networks-ircs/institute-for-prostate-cancer-research/Exercise-Recommendations-for-Prostate-Cancer-English.pdf

• David Muslin sent: 5:53 PM

  Correction, sorry. I only started pet-PSA scans once my psa started to rise…….one year after drug holiday. Then I was was doing scans every 3 months watching for Mets.

•  Richard Wassersug (Vancouver) sent: 6:03 PM

  Sorry, got to go. richard.wassersug@ubc.ca

• Frank Ciambra sent: 6:04 PM

  goodnight sorry

•  Julian – Houston sent: 6:22 PM

  goodnight all

• rd sent: 6:24 PM

  Hi Folks…. tech issues and VSS obligations.

• Ancan – Bill sent: 6:24 PM

  Nice to see you again RD.

• rd sent: 6:36 PM

  Mark Finn GRHS tried for AMG509

• dan, alexandria sent: 6:48 PM

  Is there a time limit if you are on Reclast?

• John A sent: 6:49 PM

  same drug, Dan, zoledronic acid

• AnCan – rd sent: 6:50 PM

  Probably the same 5 years

• Jack sent: 6:59 PM

  That relieves me. Thanks David!

• AnCan – rd sent: 7:08 PM

  Thomas – Sokolova is giving you the run around. If me, I’d iinsist on denosumab in an appropriate dose.

• Thomas M sent: 7:22 PM

  The zoledronic acid vs denosumab discussion was right on point for me. Thanks for everyone’s input.

• David Muslin sent: 7:25 PM

  I have to go. Thanks all

• George (Chicago) sent: 7:26 PM

  Thank you, gentlemen.

• AnCan – rd sent: 7:08 PM  Thomas – Sokolova is giving you the run around. If me, I’d iinsist on denosumab in an appropriate dose.
• Thomas M sent: 7:22 PM The zoledronic acid vs denosumab discussion was right on point for me. Thanks for everyone’s input.
• David Muslin sent: 7:25 PM I have to go. Thanks all
• George (Chicago) sent: 7:26 PM Thank you, gentlemen.