Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

 

AnCan is closing out its Annual Fundraising Campaign. If you haven’t donated yet, consider the priceless value we bring . Please donate – especially if you watch our recordings and are not on our Mailchimp list. https://ancan.org/donate/

Hear Founder, rick davis talk about how AnCan came to be in this 20-min podcast dropped this week on Empowered Patient Radio http://empoweredpatientradio.com/virtual-support-groups-remove-barriers-encourage-sharing-honest-experiences-to-fight-misinformation-with-rick-davis-ancan

AnCan thanks the following sponsors for making this recording possible: Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room

Editor’s Pick: After 15 years, Prostate cancer recurs for one Gent; and the 2nd time, 13 years later, for another.

Topics Discussed 

Newbie needs to switch to a GU MO; PrCa metastasizes after 15 yrs; singlet to doublet during RT; Pluvicto failing after 10x sessions – STEAP1 xaluritamig (AMG509 ) next but heads up!; early signs of 2nd recurrence; Eligard vs Firmagon (agonist vs antagonist LHRH); first GU med onc appointment coming up; managing hot flashes; Oxybutynin again; doc can’t get approval right so switches drug; PSMA shows Nodes may not need RT; abiraterone dosing;

Chat
  • Rick Davis sent: 6:10 PM

    PLEASE – no mention of the Championship Game tonight. Some peeps are recording it.

  • Rick Davis sent: 6:41 PM

  • Julian – Houston sent: 7:02 PM

    Need to leave – pass my bedtime. Catch you all next week!

  • Bob Schwartz U.S.N. Venice, FL. sent: 7:03 PM

    Another GOOD Mtg., have to go, see everyone next week.

  • Rick Davis sent: 7:26 PM

    Xaluritamig (AMG 509) is a novel bispecific T-cell engager (TCE) immunotherapy

  • Bob Y — Los Angeles sent: 7:27 PM

    Appreciate everyone. I, too, have to go. See you next week.

  • Len sent: 7:30 PM

    STEAP1 (Six-Transmembrane Epithelial Antigen of the Prostate 1) is detected in prostate cancer (PCa) primarily through tissue analysis (immunohistochemistry), showing overexpression in malignant cells, and via liquid biopsies (extracellular vesicles in plasma), using methods like nanoscale flow cytometry,

  • AnCan–John A sent: 7:31 PM

    thanks Len

  • Frank Ciambra sent: 7:32 PM

    thank you

  • Rick Davis sent: 7:32 PM

    Doubling time very unreliable at such low levels, Neil

  • dan-s sent: 7:40 PM

    I also have to scoot… thanks all.

  • Barbara and Joe sent: 7:54 PM

    are you saying lupron?

  • Jim Marshall, Veteran, Alexandria, VA sent: 7:55 PM

    Lupron & Eligard are the exact same drug. Jim

  • Rick Davis sent: 7:56 PM

    Are you asking about the Depot shots?

  • Rick Davis sent: 7:57 PM

    Oxybutynin…. good for hot flashes if you are on abi

  • Steve L sent: 7:57 PM

    Must leave at 7, Best to all.

  • Alain sent: 7:58 PM

    See you next time guys!

  • Barbara and Joe sent: 7:58 PM

    I was asking about a two tier therapy

  • Steve Lsent: 7:59 PM

    no , thank you.

  • Alfredo in Houston, TX sent: 8:00 PM

    I must disconnect shortly. Thanks to everyone; I learn something new from every session.

  • Rick Davis sent: 8:01 PM

    ADT + ARSI = doublet. ADT can be one of several drugs.

  • Thomas Matica sent: 8:02 PM

    Signing out. Thanks to everyone. Peace.

  • Len sent: 8:02 PM

    Dan – Trade name for oxybutynin is Ditropan.

  • Barry Blomquist sent: 8:06 PM

    Thanks guys!

  • Richard B, Silver Spring, MD sent: 8:09 PM

    As much as I would like to remain I need to bow out for the evening. I can save my question until next session. Always appreciate the information on these meeting. Good night!

  • Alfredo in Houston, TX sent: 8:09 PM

    good night

  • Dan – Schenectady, NY sent: 8:16 PM

    Thank you – have to go

  • Robert sent: 8:18 PM

     Thanks for another good meeting.

  • Ed L sent: 8:22 PM

    Thanks for the input. Good night.

  • Jon McPhee Toronto sent: 8:26 PM

    Bed time. Good meeting again. Night.

  • Bruce Schrimpf sent: 8:36 PM

    Thanks for the great meeting!

  • Barbara and Joe sent: 8:37 PM

    Thanks all

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/5/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/5/26

HAPPY NEW YEAR to all AnCan’s YouTube viewers.    AnCan is closing out its Annual Fundraising Campaign. If you haven’t donated yet, consider the priceless value we bring . Please donate – especially if you watch our recordings and are not on our Mailchimp list. https://ancan.org/donate/

 

Hear Founder, rick davis talk about how AnCan came to be in this 20-min podcast dropped this week on Empowered Patient Radio http://empoweredpatientradio.com/virtual-support-groups-remove-barriers-encourage-sharing-honest-experiences-to-fight-misinformation-with-rick-davis-ancan

AnCan thanks the following sponsors for making this recording possible: Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room

HEADSUP – another long session!

Editor’s Pick: Like London buses, topics come in clusters this week – post-surgery recurrence, and monotherapy daro

Topics Discussed

Recurrence 3+ months post-surgery is confusing given medical reports; sitting on hands post 2017 RRP has dire cinsequences; more rapid recurrence requires PSMA scan for younger Gent; low T post treatment raises question whether to force it castrate; oxybutinin manages hot sweats… ARSI makes no difference; Gent considers going from doublet to mono; recently diagnosed denovo Mx man learns he’s 5+4; should he keep one Pluvicto session in reserve?; get a DEXA scan before starting bone stregthener; can a layman read their PSMA scan?; is he ready for mono daro?; should a FAP (Fibroblast Activation Protein Inhibitor) scan be considered?; PSMA needed as PSA rises post IHT; connections between prostate and thyroid cancer; Gent resumes doublet but doesn’t watch PSA – more concerned with duration?!?

Chat
  •  Jim Stewart Reno, NV sent: 7:24 PM

    Family commitment have to sign off…Happy New Year everyone

  • Jim Marshall, Veteran, Alexandria, VA sent: 7:36 PM

    My solution for HOT FLASHES at night has been is even if the room is 55, I have a 12″ fan blowing directly on my face. This is done year round.

  • Paul Schomer sent: 7:50 PM

    I am not, no, Jim

  • RJ Smith (Seattle) sent: 7:50 PM

    NTD–will update next week on how Chemo#3 goes (docetaxel infusion tomorrow, fingers crossed).

  • Thomas Matica sent: 8:07 PM

    Leaving the meeting. Thanks to everyone. Happy New Year.

  • Jim Marshall, Veteran, Alexandria, VA sent: 8:11 PM

    Eric – When you are fatigued, go out and exericse despite the body telling you NOT!!!!

  • S. Datta sent: 8:14 PM

    FAPI (Fibroblast Activation Protein Inhibitor)

  • Larry Schuller – Alaska sent: 8:18 PM

    It is not crazy to want your testosterone back. Intermittent ADT can do that and it is showing promise as a tactic. Bipolar ADT (BAT) is a little crazier, but has some promise also. If you want to go wild, check out Dr Robert Gatenby’s work at Moffit in Florida. Intersesting stuff there.

  • John G. sent: 8:19 PM

  • AnCan – rick sent: 8:20 PM

  • Jeffrey Green sent: 8:23 PM

    Jay Mills Chatanooga- Though I didn’t follow the whole conversation, I heard you say something to the effect of, “I may have mets all over the place, in addition to what shows on PSMA.”

  • Barry Blomquist sent: 8:28 PM

    Have to jump – thanks everyone. Happy New Year

  • Eric Curtis sent: 8:30 PM

    Thanks all – gotta go

  • Jeffrey Green sent: 8:31 PM

    Got to start winding down here. Thanks for all you guys. See you next time.

  • Len sent: 8:34 PM

    Source is AI: Bidirectional Risk: Men diagnosed with thyroid cancer have a roughly 28% to 30% higher risk of later being diagnosed with prostate cancer compared to the general population. Conversely, men with prostate cancer are more likely to be diagnosed with thyroid cancer.

  • Robert sent: 8:35 PM

    Thanks Len. I read the same thing.

  • dan-s sent: 8:49 PM

    Thanks all… another good session. Have to sign off for the evening. Happy New Year…

  • Jay T in MN sent: 8:50 PM

    My hospital was charging the insurance company about $20,000.

  • gary peters sent: 8:50 PM

    I did not know this about thyroid C and PC. Thank you.

  • Jon McPhee Toronto sent: 8:50 PM

    Do a PSA test once a month. Cheap. PSMA/PET is expensive and harder to get.

  • Jay T in MN sent: 8:51 PM

    I “only” had to pay $1000 for my portion of PET PMSA

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 23, 2025

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 23, 2025

AnCan is in its Annual Fundraising Campaign. Please donate – especially if you watch our recordings and are not on our Mailchimp list. https://ancan.org/donate/

Hear Founder, rick davis talk about how AnCan came to be in this 20-min podcast dropped this week on Empowered Patient Radio http://empoweredpatientradio.com/virtual-support-groups-remove-barriers-encourage-sharing-honest-experiences-to-fight-misinformation-with-rick-davis-ancan

AnCan thanks the following sponsors for making this recording possible: Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room

HEADSUP – long session

Editor’s Pick: AFib may dictate use of ARSI – 2nd line anti-androgen

Topics Discussed

Dublin EI Newbie needs a GU MO; … and so does 85 yr old from Eau Claire, WI who’s Mayo doc has lost the way; roller coaster metastatic Gent starting with Kishan at UCLA; almost through RT, and finds germline CHEK2; doing well and very thankful to AnCan; germline BRCA2 man not gettiing SoC in Mississippi; great chemo results – now explore debulking; should a man with Afib be on abiraterone?; waiting for PSMA scan after 3x Pluvicto; fatigue & brain fog from abi doublet; avoid 6-month depot LHRH; Dr. Szmulewicz recommends debulking; Florida vacay interferes with treatment plan; 2nd opinion on Bx required; SBRT vs IMRT for man with urinary issues

Chat
  • AnCan – rick sent: 4:35 PM

    Silke Gillesen

  • AnCan – rick  sent: 4:55 PM

  • AnCan – rick sent: 4:58 PM

  • Len sent: 5:05 PM

    Don Larsen should be on a bone strengthener, if not already on one.

  • Jay in MN sent: 5:12 PM

    Sounds like it!

  • AnCan – rick sent: 5:55 PM

  • AnCan – rick sent: 5:59 PM

  • Jon McPhee Toronto sent: 6:07 PM

    Gotta go. Catch up next year. Merry Christmas and Happy New Year to everyone.

  • Alan M – New Jersey sent: 6:09 PM

    Happy Holidays to all. Good night.

  • Steven Waite sent: 6:16 PM

    Got to run. Thank you all very much. Happy Holidays one and all.

  • Barry Blomquist sent: 6:30 PM

    Have to jump, Merry Christmas Everyone!

  •  AnCan – rick sent: 6:32 PM

    switch from abi from to daro

  • gary peters sent: 6:35 PM

    Same from me, gents.

  • Eric Curtis sent: 6:36 PM

    Great to see everyone. Happy Holidays to all.

  • Bob Alvord sent: 6:39 PM

    Gotta run. A very Merry Christmas and Happy New Year to everyone.

  • Dan – Schenectady, NY sent: 6:40 PM

    Merry Christmas all.

  • AnCan – rick sent: 6:47 PM

    Ep-stine! Dr. Jonathan Epstein – https://advanceduropathology.com/ Tel: 516-760-2037 jepstein@imppllc.com

  • AnCan – rick sent: 6:47 PM

    Dr. Ming Zhou Mount Sinai Health System Department of Pathology, Box 1194 Annenberg Bldg. 15th FL 1468 Madison Ave New York, NY 10029 Email: Ming.zhou@mountsinai.org Telephone: (212)241-8881

  • Jeff Marchi – San Francisco sent: 6:49 PM

    Gotta run. Merry Christmas and happy new year to all.

🌿 FDA Position on Cannabis and Cannabinoids

🌿 FDA Position on Cannabis and Cannabinoids

🌿 FDA Position on Cannabis and Cannabinoids

(Here is my take on this article Therapeutic Use of Cannabis and Cannabinoids A Review JAMA Network, 11/26/25.  On a personal side, I use CBD to help me sleep, and with a little (5%) addition of THC, it is a great anxiety calmer – Sally Torgeson, AnCan Blood Cancer Moderator & Multiple Myeloma Coach)

Unapproved Cannabis

  • The FDA has NOT approved the cannabis plant (botanical marijuana) for any medical use or indication.
  • Because it is classified as a Schedule I controlled substance under federal law, the FDA has not found it to be safe or effective for the treatment of any disease or condition [1.1, 1.7].
  • It is currently illegal to market CBD by adding it to food or labeling it as a dietary supplement in interstate commerce [2.1, 2.5].

FDA-Approved Cannabinoid Drugs

The FDA has approved a small number of prescription drugs containing either a purified cannabis-derived compound or synthetic cannabinoids:

  • Epidiolex (Cannabidiol or CBD): The only FDA-approved drug that contains a purified substance derived directly from the cannabis plant. It is approved to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, and Tuberous Sclerosis Complex in patients one year of age and older [1.8, 2.1].
  • Marinol and Syndros (Dronabinol): Contain synthetic Δ9-tetrahydrocannabinol (THC). Approved for:
    • Nausea and vomiting associated with cancer chemotherapy in patients who have not responded to conventional antiemetic treatments [2.2, 2.3].
    • Anorexia associated with weight loss in patients with HIV/AIDS [2.3].
  • Cesamet (Nabilone): Contains a synthetic substance that is chemically similar to THC. Approved for chemotherapy-induced nausea and vomiting [1.1, 2.3].

Regulatory Context

  • The FDA maintains its authority to regulate products containing cannabis or cannabis-derived compounds, even those derived from hemp (cannabis with less than 0.3% THC), under the Federal Food, Drug, and Cosmetic (FD&C) Act [1.4].
  • The FDA supports the development of new drugs through proper clinical trials to ensure they meet standards for safety and effectiveness [1.1, 2.4].

FDA-Approved Cannabinoid Drugs and Their Conditions


Drug Name (Active Ingredient) Source FDA-Approved Condition(s)
Epidiolex (Cannabidiol or CBD) Purified, plant-derived CBD Seizures associated with: * Lennox-Gastaut syndrome (LGS) * Dravet syndrome (DS) * Tuberous Sclerosis Complex (TSC)
Marinol and Syndros (Dronabinol) Synthetic THC ($ \Delta9 $-tetrahydrocannabinol) Nausea and vomiting caused by cancer chemotherapy (when other antiemetics have failed) * Anorexia (loss of appetite) associated with weight loss in patients with HIV/AIDS
Cesamet (Nabilone) Synthetic cannabinoid (similar to THC) Nausea and vomiting caused by cancer chemotherapy (when other antiemetics have failed)

Key Takeaway

  • Epidiolex is the only drug approved that contains a substance derived directly from the Cannabis plant (CBD). It represents the strongest evidence for cannabinoid efficacy in reducing seizure frequency in certain rare forms of epilepsy [1.1, 1.2].
  • The synthetic THC compounds (Dronabinol and Nabilone) are used primarily as a last resort for severe nausea/vomiting related to chemotherapy and for appetite stimulation in AIDS patients [1.2, 2.8].

The FDA has not approved the use of the whole cannabis plant for any medical condition, stressing the importance of standardized, tested pharmaceuticals for patient safety and proven effectiveness [1.7].1

 

🏷️ Off-Label Use vs. Unapproved Use

1. Off-Label Use (Legal and Regulated)

 

This applies only to drugs that the FDA has already approved.

  • What it is: Using an FDA-approved drug (like Epidiolex, Marinol, or Cesamet) for a condition, dose, or patient population that is not specifically listed on the drug’s official label.   
  • Legality: It is legal for a licensed physician to prescribe an approved drug for an off-label use if they believe it is medically appropriate for their patient.
  • FDA Position: The FDA does not regulate the practice of medicine; however, the manufacturer cannot market or promote the drug for the off-label use. The safety and efficacy for the off-label use have not been verified by the FDA’s rigorous testing process.

Example: A doctor prescribing Marinol (Dronabinol), which is approved for nausea from chemotherapy, to a patient for chronic pain. The drug is approved, but the condition (chronic pain) is not on the label.

2. Unapproved Use (Non-FDA Approved Products)

This applies to the cannabis plant itself and most CBD/cannabinoid products on the market.

  • What it is: Using the whole cannabis plant (botanical marijuana) or non-FDA-approved cannabis-derived products (like most CBD oils, edibles, or topicals) for any medical purpose.
  • Legality:
    • Federal: The whole plant is a Schedule I controlled substance and is not federally approved for any medical use.   
    • State: Use may be legal under state medical or recreational cannabis laws, but this does not change its status as an unapproved drug under federal FDA law.
  • FDA Position: The FDA considers these products unapproved drugs and/or illegally marketed products (especially when CBD is added to food or marketed as a dietary supplement), as they have not been tested for safety, effectiveness, or quality assurance.   

Example: A patient using a CBD tincture (which is not Epidiolex) to treat anxiety, or using THC flower to help with multiple sclerosis symptoms.


To correspond with Sally, please send an email to info@ancan.org, and we’ll be sure to send along.

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/19/26

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 15, 2025

Hi-Risk/Recurrent/Advanced PrCa Video Chat, Dec 15, 2025

AnCan thanks the following sponsors for making this recording possible: Bayer, Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.

AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download

All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/

Join our other free and drop in groups:
Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/
Veterans Healthcare Navigation… 1st & 3rd Tuesdays @ 8.00 pm Eastern Schmier Room https://ancan.org/veterans/
Veterans Speaking freely… 4th Tuesday @ @ 8.00 pm Eastern Schmier Room

Editor’s Pick: Finishing 10x Pluvicto; and, following up post-surgery for BRCA germline Gent

Topics Discussed

Endorsing AnCan; 10 rounds of Pluvicto – with a break after 6; low dose estrigen enquiry; Newbie want to know when to intervene on recrrence post-surgery; Tempus report shows PTEN and more; cribriform favors radiation over surgery; time for another PSMA scan; IHT or mono daro – beware of gynecomastia; can reduciing daro dose loer fatigue?; more on cribriform and RT; debulking primary tumor post chemo; BRCA germline Gent wondes when to intervene with RT post RP – and if to include HT

Chat
  • Jeff Marchi – San Francisco

    sent: 6:12 PM

    friday this week

  • Thomas Matica

    sent: 6:14 PM

    Glad to hear Peter Kafka is doing well.

  • Stan Friedman

    sent: 6:29 PM

    after 5 sessions, my psa is now undetectable

  • Mark N

    sent: 6:30 PM

    What is the drug that was just discussed?

  • Larry Schuller – Alaska

    sent: 6:31 PM

    Mark, Pluvicto work the same way imaging for PSMA-PET scans do. Instead of just giving an image of where the cancer is, it delivers a higher dose that is therapeutic

  • Mark N

    sent: 6:31 PM

    Thanks!

  • AnCan–John A

    sent: 6:33 PM

    Lee–still undetectable psa?

  • Larry Schuller – Alaska

    sent: 6:34 PM

    Many side effecs of standard ADT is actually caused by estradiol deficiency (which is caused by the absence of testosterone). This deficiency is the same as what causes osteopoosis in post-menopausal women.

  • Larry Schuller – Alaska

    sent: 6:35 PM

    Men normally have between 15 and 50 levels of estradiol

  • Larry Schuller – Alaska

    sent: 6:36 PM

    Breast growth and nipple sensitivity is a side effect of standard ADT too, but at a lower incidence than with estradiol.

    Jerry G, Brighton, MI

    sent: 6:39 PM

    I’ll add support for higher dose estradiol, for me in the absence of testosterone. My osteopenia cleared up, and I am now in the normal range for bone density. I have been on permanent ADT for almost 7 years now, and estradiol for just over 6. My PSA is still undetectable

    Larry Schuller – Alaska

    sent: 6:49 PM

    Tom Miller’s Lymph nodes?

  • Lee Baylin, Baltimore

    sent: 6:52 PM

    Dr. John, I’m still undectable.

  • AnCan – rick

    sent: 6:59 PM

    Curtis DeVille an Channing Paller at Sibley

  • Bob Schwartz U.S.N. Venice, FL.

    sent: 7:00 PM

    Once again, many thanks to the Unknown Anonymous Benefactor, who is matching donations to AnCan. Please know that your kindness is very much appreciated. Good meeting as usual, unfortunately have to go early.

  • Larry Schuller – Alaska

    sent: 7:08 PM

    A promising area of research, though

  • Larry Schuller – Alaska

    sent: 7:09 PM

    Immunotherapy is a promising area of research.

  • Larry Schuller – Alaska

    sent: 7:09 PM

    Immunotherapy is a promising area of research

  • Larry Schuller – Alaska

    sent: 7:09 PM

    Oops. Sorry about the triple post

  • Eric James; Tyler TX

    sent: 7:12 PM

    Genetic Variant Results ALK – p.G5R – c.13G>A Missense variant Assessment:Detected CDKN2A – CDKN2A Copy number loss Assessment:Detected CDKN2B – CDKN2B Copy number loss Assessment:Detected MTAP – MTAP Copy number loss Assessment:Detected PIK3CA – p.E545K – c.1633G>A Missense variant (exon 9) – GOF Assessment:Detected PTEN – p.A34fs – c.101del Frameshift – LOF Assessment:Detected TMPRSS2::ERG Fusion – TMPRSS2 – ERG Chromosomal rearrangement Assessment:Detected

  • RJ Smith (Seattle)

    sent: 7:12 PM

    SYNC-T? https://syncromune.com/science/

  • Darren Chervitz

    sent: 7:17 PM

    Gedatolisib is a PI3K/AKT/mTOR (PAM) pathway inhibitor showing promising early results in clinical trials for metastatic castration-resistant prostate cancer (mCRPC), often combined with AR inhibitors like darolutamide, targeting the PI3K pathway which is frequently altered in advanced prostate cancers, especially with PTEN loss, to control cell growth and survival, with studies aiming to find optimal doses and demonstrate improved survival and response rates.

  • Larry Schuller – Alaska

    sent: 7:26 PM

    Get a baseline bone density, too

  • Larry Schuller – Alaska

    sent: 7:29 PM

    Exercise program. A healthy body withstands the rigors of treatment better

  • RJ Smith (Seattle)

    sent: 7:30 PM

    Along with all the other tests, PROSTOX might help to know if you are prone to long-term side effects from the radiation. Most people aren’t. Like Rick said, though, if you’ve decided on radiation–might just take go for it. 😉

  • Steve L

    sent: 7:44 PM

    By the way, My immunotherapy induced Pulmonary embolism cleared this summer after about 12 months. I started feeling better immediately. They have pulled me off Eliquis. I am back to scuba diving. Currently feeling very good.

  • AnCan–John A

    sent: 7:46 PM

    Noted, Steve. that’s good

  • Bruce Schrimpf

    sent: 7:55 PM

    Again A very good discussion! Should I not see you before, Merry Christmas!

  • AnCan – rick

    sent: 8:00 PM

    https://jamanetwork.com/journals/jamaoncology/article-abstract/2840006?guestAccessKey=a83645e8-deae-423a-9139-d772a3301482&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jamaoncology&utm_content=olf-recommended-tfl_&utm_term=110625

  • Larry Schuller – Alaska

    sent: 8:15 PM

    Re: Second reads on PSMA-PET scan. I had a scan at Fred Hutch Cancer Center and the report was MUCH MORE detailed than the scan I had at my local imaging center. So, Second reads on the original scan imaging is valuable, in my opinion.

  • Larry Schuller – Alaska

    sent: 8:17 PM

    On top of that, the written report is only words. Actually showing the imaging to my surgeon saved me an extra surgery. Not mentioned on the report’s text wat that a reservoir from a prior surgery would complicate a robotic prostatectomy. It turns out that if a robotic had been started, it would have had to have been aborted, necessitating a subsequent open procedure.

  • Larry Schuller – Alaska

    sent: 8:18 PM

    Show your original imaging to your doctors, especially if approaching surgery

  • dan-s

    sent: 8:21 PM

    Thanks all for another great mtg – I have to leave (up early tomorrow)

  • AnCan – rick

    sent: 8:22 PM

    Gents – long posts in the Chat poses a problem when we write up these meetings. There is a limit in You Tube on what we can paste.