Hi-Risk/Recurrent/Advanced PCa Video Chat, Aug 5, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Novartis, Telix & Blue Earth Diagnostics.
If you missed any recent recordings, you’ll find a full list either on our YouTube Playlist (click above) or visit our Blog Post https://ancan.org/our-recent-blog-posts-in-case-you-missed-them/ Sign up for our Blog by checking the New Blog box at https://ancan.org/contact-us/
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime!
Editors Pick: Crazy increases in PSA suggests therapy is not working; Dr. Bob GRHS (rd)
Topics Discussed
Dr. Bob GRHS’; low level mCRPC – what next?; fermented foods; starting olaparib with somatic BRCA2; chemo holiday for our foamy gland man; long resistant gent starts mono or double HT in the Fall; Vit D and Metformin discussion; heart is solid – PSMA to follow; erratic, fluctuating PSA suggests Tx not working – needs 2nd opinion; Decipher not useful for this situation; stopped abi and prednisone on his schedule + psych issues; 2 gents start start HT for 1st time; Intermittent HT discussion; restarting mono LHRH.
HAHA. Yes. That’s exactly what I was thinking. But yes. The older crowd. I really want to make the under 60 zoom Thursday but I’ll be playing taxi cab during that time. Sigh.
CALCIUM SCORE PRESENCE of CAD (coronary artery disease) O No sign of CAD 1-10 Minimal signs of CAD 11-100 Mild signs of CAD 101-400 Moderate signs of CAD 401+ Extensive signs of CAD
Frank Fabish Columbus OH
sent: 8:33 PM
Thanks for listening guys. Got to run. thanks for the dialogue.
Michael McCabe
sent: 8:42 PM
Got to go guys, see everyone at next meeting
Steve Roux, MI
sent: 8:43 PM
GREAT Meeting guys – I need to take my rescue puppy out for a walk. Goodnight all!
THOMAS M
sent: 8:52 PM
I have used the “Cancer Care” booklet from the FLCCC Alliance, Dr. Paul Marik, MD. The discussion about vitamin D brought this to mind. It suggests repurposed uses of various supplements and pharmaceuticals for cancer treatment. Its worth a glance.
Gary P
sent: 8:55 PM
https://betterdayscounselingllc.com/
John A
sent: 9:10 PM
gotta stop now guys see you next week
Matt M
sent: 9:12 PM
gotta go boys, have a great week! I’ll be on some next onens…..
THOMAS M
sent: 9:22 PM
Time to scoot. Thanks all.
Dr. Jeff
sent: 9:39 PM
gotta sign off. Past my bedtime. see everyone next week
Talking Estradiol (E2) for Recurrent and Advanced Prostate Cancer: Wassersug et al
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Novartis, Telix & Blue Earth Diagnostics. Sincere apologies to all for failing to record our May 6 Group. It was totally a platform fault and not down to AnCan. As regulars are aware. this is a very rare event. AnCan hopes this session might make up for it.
Estrogen in its various forms has long been used as a primary and secondary means of managing prostate cancer. Primarily it can be used in place of an LHRH ADT drug. In its secondary capacity, it can be employed in addition to an LHRH drug to help men cope with side effects arising from lack of estrogen caused by the LHRH drug. These side effects include hot flashes and weakening bone density. Today Estradiol (E2) is considered to be a safe treatment when used as a skin patch or gel versus its original application in pill form that carried significant cardiovascular risks.
The foremost peer expert on the use of estrogen to manage prostate cancer is Richard Wassersug, Ph.D, author of Androgen Deprivation Therapy: An Essential Guide for Prostate Cancer Patients and Their Loved Ones that is now in its 3rd Edition https://connect.springerpub.com/content/book/978-0-8261-8403-0. Richard is also an AnCan Advisory Board Member.
In this 60 +minute discussion, Dr. Wassersug talks with two patients about using estradiol. One has used for primary control for 17 years, and the other just started using an Estradiol patch to control side effects alone. He is also joined by AnCan advanced PCa peer Moderators, Dr. John Antonucci and Rick Davis.
Rechallenging advanced disease with enzalutamide after Pluvicto is mentioned towards the end. Dr. Wassersug has since clarified that he favors rechallenging advanced disease with previous therapies after some form of radiation based on the abscopal effect. The use of enzalutamide in this context is not based on trial evidence.
AnCan asks that you first read Richard Wassersug’s book before reaching out to him. AND… Dr. Wassersug urges you to spend as much time exercising today as you have taken to watch this video!
Hi-Risk/Recurrent/Advanced PCa Video Chat, Feb 5, 2024
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Join our other free and drop in groups: Men (Only) Speaking Freely…1st & 3rd Thursdays @ 8.00 pm Eastern https://ancan.org/men-speaking-freely/ Veterans Healthcare Navigation… 4th Thursday @ 8.00 pm Eastern https://ancan.org/veterans/
Are eye issues related to hormone therapy?; Orgovyx AND Lupron vs Orgovyx OR Lupron?; Pluvicto may be in his future; time for PSMA scan and possible end to 6 yrs HT free; exercise guidance; awaiting PSA; next steps post chemo; monotherapy darolutamide; somatic testing; bulging disc gets in the way of exercise
Hi-Risk/Recurrent/Advanced PCa Video Chat, Dec 4, 2023
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Take a trip with ketamine!! + lotsa useful tips this week. (rd)
Topics Discussed
Only ONE QB, and make sure they are the best choice; out-of-touch rad onc; Keytruda fails – moving on to Pluvicto; ketamine provides remarkable insight BUT don’t overdo it; Mettle Health & BJ Miller; community med onc doesn’t provide standard of care; is a PCa collective voice feasible?… old hands think not!; name the doc you want to see via your provider portal; renal cysts are rarely malignant; use FMI’s mobile phlebotomist to save time; how YOU can load images to MyChart; what to do about ADT fatigue… possibly over exercising??; is PSA too low for liquid biopsy analysis when you have known mets?; hotel deals available for cancer treatment.
Anti androgens: abiraterone, enzalutamide, apalutamide, darolutamide
Bob Gsent · 7:02 PM
Have to go now. I’ll be back a lot sooner. Have a good night.
Jim Marshall, Alexandria, VAsent · 7:10 PM
DOD’s Center for Prostate Disease Research gets $110M per year for Prostate Research. They hire contractors to analyze the proposals and do not go outside their own sphere. Jim Marshall
Hi-Risk/Recurrent/Advanced PCa Video Chat, Nov 20, 2023
HAPPY THANKSGIVING TO ALL OUR VIEWERS… may it be peaceful and full of gratitude.
AnCan is grateful to the following sponsors for making this recording possible: Bayer, Foundation Medicine, Pfizer, Janssen, Myriad Genetics, Myovant, Telix & Blue Earth Diagnostics.
AnCan respectfully notes that it does not accept sponsored promotion. Any drugs, protocols or devices recommended in our discussions are based solely on anecdotal peer experience or clinical evidence.
AnCan cannot and does not provide medical advice. We encourage you to discuss anything you hear in our sessions with your own medical team.
AnCan reminds all Participants that Adverse Events experienced from prescribed drugs or protocols should be reported to the pharmaceutical manufacturer or the FDA Adverse Event Reporting System (FAERS). To do so call 1-800-332-1066 or download interactive FDA Form 3500 https://www.fda.gov/media/76299/download
AnCan’s Prostate Cancer Forum is back (https://ancan.org/forums). If you’d like to comment on anything you see in our Recordings or read in our Reminders, just sign up and go right ahead. You can also click on the Forum icon at the top right of the webpage.
All AnCan’s groups are free and drop-in … join us in person sometime! You can find out more about our 12 monthly prostate cancer meetings at https://ancan.org/prostate-cancer/ Sign up to receive a weekly Reminder/Newsletter for this Group or others at https://ancan.org/contact-us/
Editor’s Pick: Persevere to the very end to hear us question docs who recommend Pluvicto knowing some mets won’t respond (rd)
Topics Discussed
Different MRI presentations can confuse; balance and falling; do dormant prostate cells express PSMA?; Pluvicto offers no quick result – Ac225 next??; don’t rush the prednisone taper; does your assigned doc have the right qualifications?; urinary issues lead to kidney failure – and a neck brace!; Orgovyx causes fewer hot flashes for some men; with mCRPC, don’t anguish over 0.1-0.3 PSA fluctuations; do historic doubling patterns hold when PCa recurs?; PCa recurs only IN the radiated gland – what next after 6 mo. HT?; ultra sensitive test redundant post-RT; does Pluvicto make sense for man with hybrid PCa?
Chat Log
Michael Wyn, Denversent · 6:15 PM
Thanks everyone. Good bye
Phil Dipaolasent · 6:19 PM
Hi, I would like a few minutes during the session today, if possible! Thanks, Phil Dipaola
sent · 6:21 PM
Phil – you have to be here in the first 10 minutes to be sure of time. PLEASE REFER TO OUR REMINDER. That’s the protocol with so many attendees.. If we have time at the end, we’ll certainly get to you.
sent · 6:22 PM
Were you tested for neuropathy?
Bill Franklinsent · 6:31 PM
Joel, if at all possible, don’t hesitate to ask for a physical therapy referral from your PCM. All the stuff Larry talked about would be worked on.
Bill Franklinsent · 6:37 PM
What age is considered elderly now? This is a serious question. Sometimes all doctors think about is the number on the age line. But many of us are in great shape.
TonyFigsent · 6:39 PM
I thought the Surf sound in Florida got louder in the winter. Maybe it is elderly shuffling their feet.
AnCan – ricksent · 6:52 PM
Google …… Alpha emitter vs Beta emitter PSMA radionuclide therapeutics
I will. turn 75 tomorrow, and I do not consider myself elderly!
My wife was a geriatric nurse. She had no time for doctors who blamed problems on an individual’s age.
AnCan – ricksent · 7:10 PM
Happy B-day to Alan Babcock!!!
JEFFERSONsent · 7:11 PM
thank you so much
Julian – Houstonsent · 7:14 PM
Happy B-day Alan!!!
Jimmy Greenfieldsent · 7:20 PM
Biological age , not the number. In my parent’s time 70 was elderly. People stopped moving. I know otherwise ‘healthy”50 year olds who are truly old, physically and/or behaviorally. Unfit, set in their ways etc. Then you have birthday boy Alan Babcock- 75 years young if ever I saw it.
sent · 7:21 PM
Hi I have a question about PSA test sensitivity. For the first time in about 6 months my level went below the ‘undetectable’ level as my local Kaiser defines it, <.06. Very grateful for that. Going forward, I’m wondering if I should be pushing Kaiser for a test with greater sensitivity? When people talk about their PSA testing I usually hear specificity below .06, but I’m not sure if there would be value for me in that ‘extra’ sensitivity. I am 3.5 years past initial radiation treatments not taking any medications at this point.
Alan Babcocksent · 7:22 PM
Thanks Jimmy
Jim Marshall, Jupiter, FL on Vacsent · 7:26 PM
You say not under treatment but have you been not being treatec for 3.5 yrs or on a treatment holiday. I’d press for PSA tests every 4 months. I am Kaiser too. but on treatment holiday gettng PSA test every month.
sent · 7:34 PM
Thank you Jim Marshall for the question; after radiation I did 2 years of Zytiga/prednisone, and haven’t yet had the need to restart.
Jim Marshall, Jupiter, FL on Vacsent · 7:36 PM
uugst PSA test ever 1-2 months because you are on holiday. In fact I get all the blood tests I got when under treatment. Kaiser has no problem with in in the DC area.
Jim Marshall, Jupiter, FL on Vacsent · 7:38 PM
although if the thought is you are in remission, then 3 months for a year and then either every 4 or 6 months going forward not needing all the other tests. Jim M
sent · 7:41 PM
Thank you Jim M!
Alan Msent · 7:46 PM
Matt, I have had the ultrasensitive PSA test done by Labcorp for 10 years. I prefer to see small changes and get an early warning of pending increases or decreased in PSA. I recommend it as long as it won’t give you anxiety.
Julian – Houstonsent · 7:47 PM
I am also doing the ultrasensitive PSA test every 3 months!
Alan Msent · 7:52 PM
Need to sign off guys. Good night.
Jim Marshall, Jupiter, FL on Vacsent · 8:03 PM
Kaiser has always given me PSA tests with 2 decimal places from the start 6.25 years ago. It has been less than 0.01 ever since I was on ABI + Lupron and into 15 months holiday.
