Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/5/26

by Rick Davis | Jan 7, 2026 | High Risk/Recurrent/Advanced, High Risk/Recurrent/Advanced Prostate Cancer, mHSPC, nmCRPC, Prostate Cancer, Recorded Groups, Uncategorized

Hi-Risk/Recurrent/Advanced PrCa Video Chat, 1/5/26

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AnCan thanks the following sponsors for making this recording possible: Novartis, Johnson and Johnson, Telix, Blue Earth Diagnostics and Foundation Medicine.
Views expressed in this Recording are solely the opinion of AnCan Foundation, our Moderators and Participants.

AnCan does not accept sponsored promotion. Any drugs, protocols or devices discussed are based solely on anecdotal peer experience or clinical evidence.
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HEADSUP – another long session!

Editor’s Pick: Like London buses, topics come in clusters this week – post-surgery recurrence, and monotherapy daro

Topics Discussed

Recurrence 3+ months post-surgery is confusing given medical reports; sitting on hands post 2017 RRP has dire cinsequences; more rapid recurrence requires PSMA scan for younger Gent; low T post treatment raises question whether to force it castrate; oxybutinin manages hot sweats… ARSI makes no difference; Gent considers going from doublet to mono; recently diagnosed denovo Mx man learns he’s 5+4; should he keep one Pluvicto session in reserve?; get a DEXA scan before starting bone stregthener; can a layman read their PSMA scan?; is he ready for mono daro?; should a FAP (Fibroblast Activation Protein Inhibitor) scan be considered?; PSMA needed as PSA rises post IHT; connections between prostate and thyroid cancer; Gent resumes doublet but doesn’t watch PSA – more concerned with duration?!?

Chat

• RJ Smith (Seattle) sent: 6:17 PM

  Hey Bob! Infusion tomorrow, so today is a good day. Sucked on a lot of ice for round #2 as you recommended, so mouth/taste was fine. Proctitis (mostly damage from ton of radiation) is pain in the a**, though–quite a bit of pain this time, but no pain today, so I’ll take it!

• AnCan – rick sent: 6:24 PM

  Promise https://www.prostatecancerpromise.org/?utm_campaign=ANCAN&utm_medium=link&utm_source=Webinar

• Jim Marshall, Veteran, Alexandria, VA sent: 6:26 PM

  When you update the Website with your info, do not enter any name of the doctor. This will be between you and Promise. Jim

• AnCan – rick sent: 6:45 PM

  Alan Bryce https://www.cityofhope.org/alan-bryce

• Len sent: 6:56 PM

  Orgovyx – relugolix

• Jeff Marchi – San Francisco sent: 6:58 PM

  EMBRLABS.COM

• Thomas Matica sent: 7:00 PM

  Bayer Patient Assistance Foundation could provide free Nubeqa (darolutamide) if you qualify. https://www.patientassistance.bayer.us/en/ I am on my third year in the program.

• Len sent: 7:06 PM

  https://jamanetwork.com/journals/jamaoncology/fullarticle/2784215?resultClick=1 Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer

• Jim Akin sent: 7:06 PM

  House guest, must go. Thanks to AnCan and Rick D for referral to Dr. Guancial in Sarasota. Had great visit last week. ADT working, PSA May 4.7, today .01, no side effects, Testro 50. Orgovyx working

• Larry Schuller – Alaska sent: 7:06 PM

  Orgovyx/relugolix pills and Firmagon/degalarix injections are both LHRH/GnRH ANTAgonists. In my opinion, superior to LHRH agonists, Lupron/leuprolide. Bot inferior (again, my opinion and personal experience) to trans-dermal estradiol (see the web site “estradiolinitiative.org” for more information or cantact me directly at ljschulr@alaska.net.

• Bob Schwartz U.S.N. Venice, FL. sent: 7:07 PM

  Jeffrey Green, you can also get the Embr Wave at Amazon (my wife got mine there).

• Jim Marshall, Veteran, Alexandria, VA sent: 7:08 PM

  https://ecancer.org/en/video/12502-apalutamide-and-salvage-radiotherapy-benefits-luminal-b-subtype-prostate-cancer has YOUTUBE video

• AnCan – rick sent: 7:12 PM

  Heath https://www.mayoclinic.org/biographies/heath-elisabeth-i-m-d/bio-20576547

•  Jim Stewart Reno, NV sent: 7:24 PM

  Family commitment have to sign off…Happy New Year everyone

• Jim Marshall, Veteran, Alexandria, VA sent: 7:36 PM

  My solution for HOT FLASHES at night has been is even if the room is 55, I have a 12″ fan blowing directly on my face. This is done year round.

• Paul Schomer sent: 7:50 PM

  I am not, no, Jim

• RJ Smith (Seattle) sent: 7:50 PM

  NTD–will update next week on how Chemo#3 goes (docetaxel infusion tomorrow, fingers crossed).

• Thomas Matica sent: 8:07 PM

  Leaving the meeting. Thanks to everyone. Happy New Year.

• Jim Marshall, Veteran, Alexandria, VA sent: 8:11 PM

  Eric – When you are fatigued, go out and exericse despite the body telling you NOT!!!!

• S. Datta sent: 8:14 PM

  FAPI (Fibroblast Activation Protein Inhibitor)

• Larry Schuller – Alaska sent: 8:18 PM

  It is not crazy to want your testosterone back. Intermittent ADT can do that and it is showing promise as a tactic. Bipolar ADT (BAT) is a little crazier, but has some promise also. If you want to go wild, check out Dr Robert Gatenby’s work at Moffit in Florida. Intersesting stuff there.

• John G. sent: 8:19 PM

  https://clinicalimagingscience.org/fibroblast-activation-protein-targeted-radiopharmaceuticals-recent-trends-in-cancer-diagnosis/

• AnCan – rick sent: 8:20 PM

  PSMA + BCR trial https://www.clinicaltrials.gov/study/NCT05588128

• Jeffrey Green sent: 8:23 PM

  Jay Mills Chatanooga- Though I didn’t follow the whole conversation, I heard you say something to the effect of, “I may have mets all over the place, in addition to what shows on PSMA.”

• Barry Blomquist sent: 8:28 PM

  Have to jump – thanks everyone. Happy New Year

• Eric Curtis sent: 8:30 PM

  Thanks all – gotta go

• Jeffrey Green sent: 8:31 PM

  Got to start winding down here. Thanks for all you guys. See you next time.

• Len sent: 8:34 PM

  Source is AI: Bidirectional Risk: Men diagnosed with thyroid cancer have a roughly 28% to 30% higher risk of later being diagnosed with prostate cancer compared to the general population. Conversely, men with prostate cancer are more likely to be diagnosed with thyroid cancer.

• Robert sent: 8:35 PM

  Thanks Len. I read the same thing.

• dan-s sent: 8:49 PM

  Thanks all… another good session. Have to sign off for the evening. Happy New Year…

• Jay T in MN sent: 8:50 PM

  My hospital was charging the insurance company about $20,000.

• gary peters sent: 8:50 PM

  I did not know this about thyroid C and PC. Thank you.

• Jon McPhee Toronto sent: 8:50 PM

  Do a PSA test once a month. Cheap. PSMA/PET is expensive and harder to get.

• Jay T in MN sent: 8:51 PM

  I “only” had to pay $1000 for my portion of PET PMSA